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- Sonderby, Ida E., et al.
(author)
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Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia
- 2020
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In: Molecular Psychiatry. - : Nature Publishing Group. - 1359-4184 .- 1476-5578. ; 25:3, s. 584-602
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Journal article (peer-reviewed)abstract
- Carriers of large recurrent copy number variants (CNVs) have a higher risk of developing neurodevelopmental disorders. The 16p11.2 distal CNV predisposes carriers to e.g., autism spectrum disorder and schizophrenia. We compared subcortical brain volumes of 12 16p11.2 distal deletion and 12 duplication carriers to 6882 non-carriers from the large-scale brain Magnetic Resonance Imaging collaboration, ENIGMA-CNV. After stringent CNV calling procedures, and standardized FreeSurfer image analysis, we found negative dose-response associations with copy number on intracranial volume and on regional caudate, pallidum and putamen volumes (β = −0.71 to −1.37; P < 0.0005). In an independent sample, consistent results were obtained, with significant effects in the pallidum (β = −0.95, P = 0.0042). The two data sets combined showed significant negative dose-response for the accumbens, caudate, pallidum, putamen and ICV (P = 0.0032, 8.9 × 10−6, 1.7 × 10−9, 3.5 × 10−12 and 1.0 × 10−4, respectively). Full scale IQ was lower in both deletion and duplication carriers compared to non-carriers. This is the first brain MRI study of the impact of the 16p11.2 distal CNV, and we demonstrate a specific effect on subcortical brain structures, suggesting a neuropathological pattern underlying the neurodevelopmental syndromes.
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| 2. |
- Kvist Geverts, Karin, 1974-
(author)
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Ett främmande element i nationen : Svensk flyktingpolitik och de judiska flyktingarna 1938−1944
- 2008
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Doctoral thesis (other academic/artistic)abstract
- The aim is to increase our understanding of the mechanisms of social categorization and discrimination, as well as the connection between them. This has been accomplished by examining Swedish refugee policy towards Jewish refugees during the Second World War and the Holocaust, as conducted by The Foreigner’s Bureau of the National Board of Health and the Ministry of Foreign Affairs during 1938−1944. The study also compares the Swedish refugee policy with that of Denmark, Switzerland, Great Britain and the United States. The investigation is guided by such concepts as social categorization, discrimination, antisemitism, organizational culture and established practice. The primary sources are documents, minutes and personal dossiers; Svensk författningssamling (legislation) and articles in Sociala Meddelanden (the National Board’s official journal).The main conclusions are that Sweden was not perceived as a country of immigration, based partly of the widespread fear that too many Jewish refugees would create a “Jewish Question”. Swedish authorities discriminated against Jewish refugees on grounds of “race” through a process of categorization. This process began already in the 1920’s, and gradually transformed the definition of “Jew” from a religious to a “racial” definition, based on the Nuremberg Laws. The differentiation of Jewish refugees in official statistics ceased in September 1943, yet it continued secretly until February 1944, encompassing the Norwegian and Danish Jews as well. One important result shows that the shift in policy – from discrimination to large scale reception – was a slow process where this differentiating practice and antisemitic perceptions remained operative. What is defined as an antisemitic background bustle is used to explain how moderate antisemitic expressions were perceived as “unbiased” and “normal” within the Swedish society. Though Sweden’s refugee policy seems similar to that of other countries surveyed, the shift in policy stands out as unique in comparison.
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| 3. |
- Estvall, Martin, 1968-
(author)
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Sjöfart på stormigt hav : Sjömannen och Svensk Sjöfarts tidning inför den nazistiska utmaningen 1932-1945
- 2009
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Doctoral thesis (other academic/artistic)abstract
- The purpose of this study is to discuss German Nazism and Nazi Germany from the point of view of two specific representatives, namely, labour and capital. This has been facilitated by analysing the content of the Swedish Seamen’s Union’s newspaper, The Seafarer [Sjömannen] and its union counterpart, the Swedish Shipowners Association’s periodical, Scandinavian Shipping Gazette [Svensk Sjöfarts Tidning], from November 1932 up to and including 1945. The shipping industry was chosen because trade was of central importance to the Swedish economy and to relations with Nazi Germany. Direct contact with Nazi Germany meant that the organisations were kept up-to-date about what was happening there.A qualitative analysis of texts and images constitutes the major part of the study. This is complemented by a quantitative examination of the intensity of reporting on Nazi Germany.There were enormous differences between the two papers, both in terms of intensity and bias, with regard to the Nazi challenge. While The Seafarer described both Nazism and Nazis in strongly negative terms, the Scandinavian Shipping Gazette chose to remain silent. The Seafarer encouraged counteractions like demonstrations, strikes, boycotts and sanctions, whereas the Scandinavian Shipping Gazette considered such measures to be “undemocratic” and argued against them. The material in The Seafarer is strongly propagandist and always keenly opposed to Nazism and anti-Semitism. The paper served as an anti-Nazi mouth-piece. The means of expression range from poems, drawings and illustrations via highly factual and biased reports to weightier multi-page ideological analyses. All in all, the Nazi regime is described as one of violence and terror that is bent on stifling both the working class and people of other “races”. In sharp contrast, the study shows that the Scandinavian Shipping Gazette dedicates itself to describing events and developments taking place in Nazi Germany.There was no class-transgressing national ideology or policy within the shipping industry with which to facilitate an understanding of the Nazi challenge. In the study, class affinity has proved to be an important, and clearly distinct, factor in the approach to Nazism.
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