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- Amirijoo, Mehdi, 1978-, et al.
(author)
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Finite Horizon QoS Prediction of Reconfigurable Firm Real-Time Systems
- 2006
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In: IEEE International Conference on Embedded and Real-Time Computing Systems and Applications,2006. - Los Alamitos, California, USA : IEEE Computer Society. ; , s. 233-
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Conference paper (peer-reviewed)abstract
- Updating real-time system software is often needed in response to errors and added requirements to the software. Stopping a running application, updating the software, and then restarting the application is not suitable for systems with high availability requirements. On the other hand, dynamically updating a system may increase the execution time of the tasks, thus, degrading the performance of the system. Degradation is not acceptable for performance-critical real-time systems as there are strict requirements on the performance. In this paper we present an approach that enables dynamic reconfiguration of a real-time system, where the performance of the system during a reconfiguration satisfies a given worst-case performance specification. Evaluation shows that the presented method is efficient in guaranteeing the worst-case performance of dynamically reconfigurable firm real-time systems.
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- Andersson, Hans, et al.
(author)
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Wild boars and farming in Sweden : an assessment of the costs
- 2016
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Reports (other academic/artistic)abstract
- Wild boar is among the most wide spread mammal in the world and is known to cause serious damages for farmers in terms of crop losses and impacts on farm infrastructure. This study estimate farmers’ cost of wild boar in Sweden, and how it is determined by land scape diversity, proxies for wild boar population, land ownership, feeding and protective measures by the farmer. Data are obtained from a survey of 3200 farmers, and the results indicate an average annual cost of SEK 28843/farm or SEK 305/ha, of which 62% arises from crop losses and 28% from adjustment and protection costs. However, 60% of the farmers reported no damage cost, and we therefore examined the determinants of the probability of damage cost and, when it occurs, the size. It was found that proxies of wild boar abundance and land scape diversity have significant and positive impact on the likelihood and magnitude of costs. Diversity in the landscape gives access to hiding opportunities for the pigs when searching for food in the agricultural fields. Share of area with forage, rented land, arable land, and protective measures all showed significant and positive effects on the size of the damage cost.
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- Andersson, Patiyan, 1978-, et al.
(author)
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Genome-wide analysis of penile cancer using high-density single nucleotide polymorphism arrays
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Other publication (other academic/artistic)abstract
- The availability of genome-wide high-density single nucleotide polymorphism (SNP) arrays makes it possible to in a structured manner study chromosome aberrations in penile cancer where little is known of disruptive genetic events. In this study 19 penile squamous cell carcinomas were analyzed using the 250k NspI SNP array from Affymetrix. We find major regions of frequent copy number gain in chromosome arms 3q, 5p and 8q, and slightly less frequent in 1p, 16q and 20q. The chromosomal regions of most frequent copy number losses were 3p, 4q, 11p and 13q. We identified four candidate genes residing in the major chromosomal regions of aberration. Eight tumours showed copy number gain of the PIK3CA gene located to 3q26.3. Five of the remaining tumours carried an activating mutation of the PIK3CA gene and these tumours showed very few chromosomal aberrations. Collectively, disruption of the PIK3CA gene was found in 13/19 samples, and presence of active phosphorylated AKT was confirmed immunohistochemically in these tumours indicating an active signalling pathway. We found copy number gain of the hTERT gene (5p15.33) in 7 samples and of the Myc gene (8q24.21) in 7 samples. Copy number loss of the tumoursuppressor gene FHIT (3p14.2) was observed in 8 samples, the same 8 samples that showed copy number gain of the PIK3CA gene. In total the PI3K/AKT and RAS/MAPK pathways were found to be activated through mutation or amplification in 64% of the cases, indicating the significance of these pathways in the aetiology of penile cancer.
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- Andersson, Patiyan, 1978-, et al.
(author)
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PIK3CA, HRAS and KRAS gene mutations in human penile cancer
- 2008
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In: Journal of Urology. - New York, USA : Ovid Technologies (Wolters Kluwer Health). - 0022-5347 .- 1527-3792. ; 179:5, s. 2030-2034
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Journal article (peer-reviewed)abstract
- Purpose: The knowledge of somatic mutations that arise in penile cancer is limited. We examined the dysregulation of components in the phosphatidylinositol 3-kinase and Ras pathways. Materials and Methods: Using single stranded conformational analysis and direct sequencing we performed mutational analysis of the PIK3CA, PTEN, HRAS, KRAS, NRAS and BRAF genes in 28 penile tumors. Results: We identified somatic missense mutations in 11 of the 28 penile cancer samples (39%). In the PIK3CA gene 8 mutations (29%) were identified that were E542K or E545K. In the HRAS gene a G12S and a Q61L mutation were found (7%). The KRAS gene contained 1 mutation (3%), that is a G12S change. PIK3CA mutations were found in all grades and stages, whereas HRAS and KRAS mutations were found in larger and more advanced tumors. The mutations were mutually exclusive, suggesting that dysregulation of either pathway is sufficient for the development and progression of penile carcinoma. Conclusions: The high frequency of mutations in the PIK3CA, HRAS and KRAS genes leads us to believe that dysregulation of the phosphatidylinositol 3-kinase or Ras pathway is significant for the development and progression of penile carcinoma.
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- Andersson, Peter, 1957-
(author)
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Surgery and anorectal function in Crohn's colitis
- 2003
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Doctoral thesis (other academic/artistic)abstract
- The study concerns surgery in Crohn's disease, particularly Crohn's colitis, its relation to medical treatment, symptomatic load, perceived health, quality of life, outcome on anorectal function and also anorectal physiologic conditions.Four hundred and thirty-two patients treated at the University Hospital, Linköping from 1970 to 1997 were included in the study. Operations and medical treatment were retrospectively reviewed, whereas symptomatic load, perceived health, quality of life, function outcome and anorectal physiology were prospectively evaluated.In a cross-sectional analysis of all patients surveilled 1995 the annual incidence of surgery was 5.7% in a population-based cohort and 10.3% in referred patients. Medical maintenance treatment was used in 61 and 55% respectively. This led to 89% of the patients being in clinical remission or having only mild symptoms and to a large proportion with a perception of good health. The treatment was paralleled by a low rate of septic and surgical complications.Surgical treatment of Crohn's colitis prior to 1990 mainly implied colectomy or proctocolectomy and thereafter almost exclusively segmental resection. The creation of a permanent stoma decreased and was rarely needed at the end of the study period when the annual risk was 0.23%. This development was basically due to a deliberate change in surgical attitude aiming at introducing similar treatment principles as for small bowel Crohn's disease With limited resections and preservation of transanal defecation. The reduced colectomy rate may have been facilitated by the introduction of immunosuppressive medical treatment as a reduction of colectomies tended to be associated with medical maintenance treatment during the later part of the study. Time from diagnosis to surgery was prolonged and stricture replaced active disease as the major indication for surgery. Symptomatic load and anorectal function outcome were better after segmental resection without the expense of an increased reresection rate. Seventy percent of patients with Crohn's colitis were in clinical remission and these patients scored quality of life similar to the general population but patients with active disease scored worse in all indexed aspects. The need of immunosuppression or previous surgery was not related to quality of life except when operated with a permanent stoma which negatively influenced psychological well being.Anorectal physiology in Crohn's disease differed from controls with increased anal resting pressures and increased rectal sensitivity. This provides possible prerequisites for later development of anal pathology such as fissures and fistulas.The study indicates that the concept oflimited surgery is applicable also in Crohn's colitis with obvious benefits for the patients. A treatment concept including medical maintenance treatment and limited resections implies that the vast majority of patients with Crohn's disease may live with only minor symptoms and minimal risk of having a permanent stoma, factors associated with a quality of life similar to that of the general population.
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