| 1. |
- Gangane, Nitin, et al.
(author)
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Prevalence and Risk Factors for Patient Delay Among Women With Breast Cancer in Rural India
- 2016
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In: Asia-Pacific journal of public health. - : SAGE Publications. - 1941-2479 .- 1010-5395. ; 28:1, s. 72-82
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Journal article (peer-reviewed)abstract
- Delay in seeking health care by women with breast cancer increases mortality risk. This study was conducted in rural India to identify risk factors associated with patient delay. A total of 212 women with primary breast cancer diagnosed between 2010 and 2012 were interviewed. Sociodemographic characteristics, time interval between seeking medical attention and appearance of symptoms, and reasons for delay were inquired. Patient delay was defined as more than 3 months between date of first symptoms and medical consultation. Logistic regression was applied to assess associations between potential risk factors and patient delay. Almost half the women with breast cancer experienced patient delay. Age more than 60 years (odds ratio = 4.9, 95% confidence interval = 1.3-18.0) was significantly associated with patient delay. Only 6.6% of patients had heard about breast self-examination. Significantly higher number of patients with delay presented with advanced clinical stage (P = .000). Health education programs should be introduced with specific strategies to shorten patient delay.
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| 2. |
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| 3. |
- Grundström, Christine, et al.
(author)
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ETS1 and PAX5 transcription factors recruit AID to Igh DNA
- 2018
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In: European Journal of Immunology. - : Wiley-VCH Verlagsgesellschaft. - 0014-2980 .- 1521-4141. ; 48:10, s. 1687-1697
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Journal article (peer-reviewed)abstract
- B lymphocytes optimize antibody responses by class switch recombination (CSR), which changes the expressed constant region exon of the immunoglobulin heavy chain (IgH), and by somatic hypermutation (SH) that introduces point mutations in the variable regions of the antibody genes. Activation-induced cytidine deaminase (AID) is the key mutagenic enzyme that initiates both these antibody diversification processes by deaminating cytosine to uracil. Here we asked the question if transcription factors can mediate the specific targeting of the antibody diversification by recruiting AID. We have recently reported that AID is together with the transcription factors E2A, PAX5 and IRF4 in a complex on key sequences of the Igh locus. Here we report that also ETS1 is together with AID in this complex on key sequences of the Igh locus in splenic B cells of mice. Furthermore, we show that both ETS1 and PAX5 can directly recruit AID to DNA sequences from the Igh locus with the specific binding site for the transcription factor. Taken together, our findings support the notion of a targeting mechanism for the selective diversification of antibody genes with limited genome wide mutagenesis by recruitment of AID by PAX5 and ETS1 in a transcription factor complex.
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| 4. |
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| 5. |
- Hebbani, Ananda Vardhan, et al.
(author)
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Evaluation of cadmium biosorption property of de-oiled palm kernel cake
- 2021
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In: International journal of phytoremediation. - : Taylor & Francis. - 1522-6514 .- 1549-7879. ; 23:5, s. 522-529
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Journal article (peer-reviewed)abstract
- Cadmium contamination is a global concern because of its widespread nature of polluting both biotic and abiotic components of ecosystem. Though many natural, chemical/synthetic components have been researched for remediation of cadmium, development of an eco-friendly, economic biosorbent still remains a challenge. Deoiled palm kernel cake (DOPC), a byproduct from palm-oil mills was investigated in the present study for its cadmium remediating capacity. DOPC was immobilized using sodium alginate polymer and biosorption studies were carried out using DOPC as adsorbent for removal of cadmium. Research revealed biosorption potential of DOPC and the optimum conditions for maximum biosorption of cadmium have been identified as 120 min of contact time, 150 rpm of agitation speed, pH 6 and 15 mg/L of initial cadmium concentration. Maximum percentage of adsorption was 99% by using 1.5 g/100 ml of adsorbent. The adsorption equilibrium data Biosorbent was characterized before and after adsorption by FTIR which showed the involvement of carboxyl, hydroxyl and amino-groups. Statement of noveltyCadmium pollution and the leading environmental problems is a global concern. Despite various attempts for development of different matrices for remediation of cadmium from contaminated samples, application of deoiled palm kernel cake (DOPC) as a biosorbent is not being explored. Present study provides quantitative data relating the richness of phytochemical repertoire DOPC possess, its resulting radical scavenging potential and its applications as an efficient, eco-friendly and economic alternative as a biosorbent matrix material for cadmium bio-remediation.
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| 6. |
- Herrera Vargas, Natalia, 1982-, et al.
(author)
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Triethyl Citrate (TEC) as a Dispersing Aid in Polylactic Acid/Chitin Nanocomposites Prepared via Liquid-Assisted Extrusion
- 2017
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In: Polymers. - : MDPI AG. - 2073-4360. ; 9:9
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Journal article (peer-reviewed)abstract
- The production of fully bio-based and biodegradable nanocomposites has gained attention during recent years due to environmental reasons; however, the production of these nanocomposites on the large-scale is challenging. Polylactic acid/chitin nanocrystal (PLA/ChNC) nanocomposites with triethyl citrate (TEC) at varied concentrations (2.5, 5.0, and 7.5 wt %) were prepared using liquid-assisted extrusion. The goal was to find the minimum amount of the TEC plasticizer needed to enhance the ChNC dispersion. The microscopy study showed that the dispersion and distribution of the ChNC into PLA improved with the increasing TEC content. Hence, the nanocomposite with the highest plasticizer content (7.5 wt %) showed the highest optical transparency and improved thermal and mechanical properties compared with its counterpart without the ChNC. Gel permeation chromatography confirmed that the water and ethanol used during the extrusion did not degrade PLA. Further, Fourier transform infrared spectroscopy showed improved interaction between PLA and ChNC through hydrogen bonding when TEC was added. All results confirmed that the plasticizer plays an important role as a dispersing aid in the processing of PLA/ChNC nanocomposites.
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| 7. |
- Kumar, Anjani, et al.
(author)
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Regulation of the DNA Repair Complex during Somatic Hypermutation and Class-Switch Recombination
- 2018
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In: Journal of Immunology. - : American Association of Immunologists. - 0022-1767 .- 1550-6606. ; 200:12, s. 4146-4156
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Journal article (peer-reviewed)abstract
- B lymphocytes optimize Ab responses by somatic hypermutation (SH), which introduces pointmutations in the variable regions of the Ab genes and by class-switch recombination (CSR), which changes the expressed C region exon of the IgH. These Ab diversification processes are initiated by the deaminating enzyme activation-induced cytidine deaminase followed by many DNA repair enzymes, ultimately leading to deletions and a high mutation rate in the Ab genes, whereas DNA lesions made by activation-induced cytidine deaminase are repaired with low error rate on most other genes. This indicates an advanced regulation of DNA repair. In this study, we show that initiation of Ab diversification in B lymphocytes of mouse spleen leads to formation of a complex between many proteins in DNA repair. We show also thatBCR activation, which signals the end of successful SH, reduces interactions between some proteins in the complex and increases other interactions in the complex with varying kinetics. Furthermore, we show increased localization of SH-and CSR-coupled proteins on switch regions of the Igh locus upon initiation of SH/CSR and differential changes in the localization upon BCR signaling, which terminates SH. These findings provide early evidence for a DNA repair complex or complexes that may be of functional significance for carrying out essential roles in SH and/or CSR in B cells.
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| 8. |
- Kumari, Anshu, et al.
(author)
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Solar Radio Spectro-polarimeter (50-500 MHz). I. Design, Development, and Characterization of a Cross-polarized, Log-periodic Dipole Antenna
- 2023
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In: Astrophysical Journal. - 1538-4357 .- 0004-637X. ; 958:2
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Journal article (peer-reviewed)abstract
- The Zeeman effect has been routinely used to image and quantify the solar photospheric magnetic field (B). Such a direct measuring technique is not yet available for the corona (Lin et al. 2004). Since almost all transient nonthermal radio emissions from the corona are either partially or fully circularly polarized, observing their polarization signatures over broad frequency ranges would be of help to estimate B as a function of heliocentric height. This article aims to describe the design and development of a Cross-polarized Log-Periodic Dipole Antenna (CLPDA), an integral part of a radio spectro-polarimeter, which works in the 50-500 MHz frequency-range and to explain the tests that were carried out to characterize it. The above frequency range corresponds to a heliocentric height range ≈1.03 < r < 2.5 R ⊙ (R ⊙ = photospheric radius), wherein the numerous coronal nonthermal transients associated with space-weather effects are observed to originate. The CLPDA is used to determine the strength and sense of polarization of the received radio signal. The uncertainty involved in the determination depends on the polarization-isolation (PI) between the two orthogonal components of a CLPDA. Some of the recent advancements made in the antenna design concepts at high frequencies (∼GHz) were adopted to reduce the PI at low frequencies (∼MHz). Throughout the above frequency range, the CLPDA has a gain, return loss, and PI of ≈6.6 dBi, ≲−10 dB, and ≲−27 dB, respectively. The average PI of the CLPDA varies from −30 to −24 dB over an azimuthal angle range 0° to ±45° within which the observations are performed regularly.
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| 9. |
- Mahawar, Lovely, et al.
(author)
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Silicon nanoparticles : comprehensive review on biogenic synthesis and applications in agriculture
- 2023
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In: Environmental Research. - : Elsevier. - 0013-9351 .- 1096-0953. ; 232
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Journal article (peer-reviewed)abstract
- Recent advancements in nanotechnology have opened new advances in agriculture. Among other nanoparticles, silicon nanoparticles (SiNPs), due to their unique physiological characteristics and structural properties, offer a significant advantage as nanofertilizers, nanopesticides, nanozeolite and targeted delivery systems in agriculture. Silicon nanoparticles are well known to improve plant growth under normal and stressful environments. Nanosilicon has been reported to enhance plant stress tolerance against various environmental stress and is considered a non-toxic and proficient alternative to control plant diseases. However, a few studies depicted the phytotoxic effects of SiNPs on specific plants. Therefore, there is a need for comprehensive research, mainly on the interaction mechanism between NPs and host plants to unravel the hidden facts about silicon nanoparticles in agriculture. The present review illustrates the potential role of silicon nanoparticles in improving plant resistance to combat different environmental (abiotic and biotic) stresses and the underlying mechanisms involved.Furthermore, our review focuses on providing the overview of various methods exploited in the biogenic synthesis of silicon nanoparticles. However, certain limitations exist in synthesizing the well-characterized SiNPs on a laboratory scale. To bridge this gap, in the last section of the review, we discussed the possible use of the machine learning approach in future as an effective, less labour-intensive and time-consuming method for silicon nanoparticle synthesis. The existing research gaps from our perspective and future research directions for utilizing SiNPs in sustainable agriculture development have also been highlighted.
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| 10. |
- Mukherjee, Anshu, et al.
(author)
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On the Optimality of the Stationary Solution of Secrecy Rate Maximization for MIMO Wiretap Channel
- 2022
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In: IEEE Wireless Communications Letters. - : Institute of Electrical and Electronics Engineers (IEEE). - 2162-2337 .- 2162-2345. ; 11:2, s. 357-361
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Journal article (peer-reviewed)abstract
- To achieve perfect secrecy in a multiple-input multiple-output (MIMO) Gaussian wiretap channel (WTC), we need to find its secrecy capacity and optimal signaling, which involves solving a difference of convex functions program known to be non-convex for the non-degraded case. To deal with this, a class of existing solutions have been developed but only local optimality is guaranteed by standard convergence analysis. Interestingly, our extensive numerical experiments have shown that these local optimization methods indeed achieve global optimality. In this letter, we provide an analytical proof for this observation. To achieve this, we show that the Karush-Kuhn-Tucker (KKT) conditions of the secrecy rate maximization problem admit a unique solution for both degraded and non-degraded cases. Motivated by this, we also propose a low-complexity algorithm to find a stationary point. Numerical results are presented to verify the theoretical analysis.
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