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1.	Bianchi, F., et al. (author) Novel sample-substrates for the determination of new psychoactive substances in oral fluid by desorption electrospray ionization-high resolution mass spectrometry 2019 In: Talanta. - : Elsevier B.V.. - 0039-9140 .- 1873-3573. ; 202, s. 136-144 Journal article (peer-reviewed)abstract A reliable screening and non invasive method based on the use of microextraction by packed sorbent coupled with desorption electrospray ionization-high resolution mass spectrometry was developed and validated for the detection of new psychoactive substances in oral fluid. The role of different sample substrates in enhancing signal intensity and stability was evaluated by testing the performances of two polylactide-based materials, i.e. non-functionalized and functionalized with carbon nanoparticles, and a silica-based material compared to commercially available polytetrafluorethylene supports. The best results were achieved by using the non-functionalized polylactide substrates to efficiently ionize compounds in positive ionization mode, whereas the silica coating proved to be the best choice for operating in negative ionization mode. LLOQs in the low μg/L, a good precision with CV% always lower than 16% and RR% in the 83(±4)-120(±2)% range, proved the suitability of the developed method for the determination of the analytes in oral fluid. Finally, the method was applied for screening oral fluid samples for the presence of psychoactive substances during private parties, revealing mephedrone in only one sample out of 40 submitted to analysis.
2.	Liu, LB, et al. (author) Design and Evaluation of [18F]CHDI-650 as a Positron Emission Tomography Ligand to Image Mutant Huntingtin Aggregates 2023 In: Journal of medicinal chemistry. - : American Chemical Society (ACS). - 1520-4804 .- 0022-2623. ; 66:1, s. 641-656 Journal article (peer-reviewed)

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Anzillotti, L. (2); Halldin, C (1); Bianchi, F. (1); Dominguez, C (1); Ilag, Leopold L (1); Hakkarainen, Minna (1); show more...; Benyahia Erdal, Nejl ... (1); Herrmann, F. (1); Nag, S (1); Herbst, T. (1); Esposito, S. (1); Greenaway, C (1); Andreoli, R. (1); Munoz-Sanjuan, I (1); Moroni, F (1); Careri, M. (1); Riboni, Nicolò (1); Agazzi, S. (1); Marezza, F. (1); Cecchi, R. (1); Davis, R (1); Brown, CJ (1); Schaertl, S (1); Khetarpal, V (1); Bard, J (1); Chen, XM (1); Lembo, A. (1); Haller, S (1); Forsberg-Moren, A (1); Khani, Y (1); Vecchi, A (1); Hayes, S (1); Liu, LB (1); Johnson, PD (1); Prime, ME (1); Coe, S (1); Haber, J (1); Hsai, MM (1); Kotey, A (1); Mangette, JE (1); Mills, MR (1); Monteagudo, E (1); Orsatti, L (1); Sproston, J (1); Bertoglio, D (1); Dickie, AP (1); Gadouleau, E (1); Giles, PR (1); Hessmann, M (1); Marriner, GA (1); show less...

University: Royal Institute of Technology (1); Stockholm University (1); Karolinska Institutet (1)

Language: English (2)

Research subject (UKÄ/SCB): Natural sciences (1)

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