| 1. |
|
|
| 2. |
- Ruilope, LM, et al.
(author)
-
Design and Baseline Characteristics of the Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease Trial
- 2019
-
In: American journal of nephrology. - : S. Karger AG. - 1421-9670 .- 0250-8095. ; 50:5, s. 345-356
-
Journal article (peer-reviewed)abstract
- <b><i>Background:</i></b> Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. <b><i>Patients and</i></b> <b><i>Methods:</i></b> The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate ≥25 mL/min/1.73 m<sup>2</sup> and albuminuria (urinary albumin-to-creatinine ratio ≥30 to ≤5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level α = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. <b><i>Conclusions:</i></b> FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049.
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
- Sunn Pedersen, Thomas, et al.
(author)
-
Experimental confirmation of efficient island divertor operation and successful neoclassical transport optimization in Wendelstein 7-X
- 2022
-
In: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 62:4, s. 042022-042022
-
Journal article (peer-reviewed)abstract
- We present recent highlights from the most recent operation phases of Wendelstein 7-X, the most advanced stellarator in the world. Stable detachment with good particle exhaust, low impurity content, and energy confinement times exceeding 100 ms, have been maintained for tens of seconds. Pellet fueling allows for plasma phases with reduced ion-temperature-gradient turbulence, and during such phases, the overall confinement is so good (energy confinement times often exceeding 200 ms) that the attained density and temperature profiles would not have been possible in less optimized devices, since they would have had neoclassical transport losses exceeding the heating applied in W7-X. This provides proof that the reduction of neoclassical transport through magnetic field optimization is successful. W7-X plasmas generally show good impurity screening and high plasma purity, but there is evidence of longer impurity confinement times during turbulence-suppressed phases.
|
|
| 6. |
- Wild, W., et al.
(author)
-
Millimetron—a large Russian-European submillimeter space observatory
- 2009
-
In: Experimental Astronomy. - : Springer Science and Business Media LLC. - 0922-6435 .- 1572-9508. ; 23:1, s. 221-244
-
Journal article (peer-reviewed)abstract
- Millimetron is a Russian-led 12 m diameter submillimeter and far-infrared space observatory which is included in the Space Plan of the Russian Federation for launch around 2017. With its large collecting area and state-of-the-art receivers, it will enable unique science and allow at least one order of magnitude improvement with respect to the Herschel Space Observatory. Millimetron will be operated in two basic observing modes: as a single-dish observatory, and as an element of a ground-space very long baseline interferometry (VLBI) system. As single-dish, angular resolutions on the order of 3 to 12 arc sec will be achieved and spectral resolutions of up to a million employing heterodyne techniques. As VLBI antenna, the chosen elliptical orbit will provide extremely large VLBI baselines (beyond 300,000 km) resulting in micro-arc second angular resolution.
|
|
| 7. |
- Arkhipov, Victor P., et al.
(author)
-
Oxyethylated Isononylphenols in Carbon Tetrachloride
- 2019
-
In: Applied Magnetic Resonance. - : Springer Nature. - 0937-9347 .- 1613-7507. ; 50:12, s. 1381-1389
-
Journal article (peer-reviewed)abstract
- Translational diffusion coefficients of ethoxylated isononylphenol molecules C9H19C6H4O(C2H4O)nH in carbon tetrachloride were measured by nuclear magnetic resonance diffusometry. The hydrodynamic radii of the molecules were determined within the framework of the Stokes–Einstein relation. We showed that ethoxylated isononylphenols in carbon tetrachloride do not form micelles, and the dependence of the diffusion coefficients and, accordingly, the hydrodynamic radii of the nonionic surfactants on the number of oxyethylene groups have a kink in the region n = 6–8.
|
|
| 8. |
- Arkhipov, Victor P., et al.
(author)
-
Study of the premicellar state in aqueous solutions of sodium dodecyl sulfate by nuclear magnetic resonance diffusion
- 2021
-
In: Magnetic Resonance in Chemistry. - : John Wiley & Sons. - 0749-1581 .- 1097-458X. ; 59:11, s. 1126-1133
-
Journal article (peer-reviewed)abstract
- Self‐diffusion coefficients of sodium dodecyl sulfate (SDS) were measured in aqueous solutions in the premicellar range of the SDS concentrations 7‐34.7 mM and temperatures 30‐900C. Average effective hydrodynamic radii and aggregation numbers of SDS in the premicellar region were determined. At C < CMC at all temperatures, the SDS solution is the solution of monomers. At C > CMC the increase of temperature leads to decrease in the effective hydrodynamic radii and the average aggregation numbers. At C >> CMC, it is impossible to reach the monomeric state by increasing the temperature.
|
|
| 9. |
- Iurchenkova, Anna A., 1997-, et al.
(author)
-
MWCNT buckypaper/polypyrrole nanocomposites for supercapasitor application
- 2020
-
In: Electrochimica Acta. - : Elsevier. - 0013-4686 .- 1873-3859. ; 335
-
Journal article (peer-reviewed)abstract
- In this work MWNT/polypyrrole nanocomposites were synthesized and investigated as electrode materials for supercapasitor application. The MWNT were synthesized by CCVD-method and precipitated as buckypaper film (NTBP). The polypyrrole was precipitated on the NTBP surface by chemical (sample NTBP_PPy_Chem) and electrochemical (sample NTBP_PPy_Elect) polymerization. The morphology and functional composition of individual and hybrid materials were investigated by microscopic and spectroscopic methods. It was obtained that the deposition method and presence of NTBP affects the polymer morphology. It was shown that PPy chemical deposition leads to the precipitation of a large amount of an amorphous polymer on a buckypaper surface. At the same time electrochemical deposition method promotes the synthesis of uniform polymer layers. In the second case, the mass of the precipitated polymer is smaller. It was found that both deposition methods are suitable for the polypyrrole deposition and can increase the buckypaper capacity almost twice. The material long cycling showed that the NTBP_PPy_Elect sample has the greatest stability. Thus, in this study, the relationship between morphology, functional composition and electrochemical properties of materials was studied. It was shown that the synthesis method allows controlling the morphology and/or functional composition of the materials. Also it was demonstrated that the synthesized structures are promising for use as supercapacitor electrodes due to the high specific capacitance and stability.
|
|
| 10. |
- Arkhipov, Victor P., et al.
(author)
-
Dynamic and structural properties of oxyethylated isononylphenols
- 2016
-
In: Mendeleev communications (Print). - : Elsevier BV. - 0959-9436 .- 1364-551X. ; 26:4, s. 355-357
-
Journal article (peer-reviewed)abstract
- Diffusion coefficients, dielectric relaxation times and refraction coefficients were measured, and activation energies of translational and rotational mobilities were determined for a series of oxyethylated phenols (neonols AF9-n) p-C9H19C6H4-O(CH2CH2O)nH, n = 4, 6, 8, 9, 10, 12, at different temperatures. The results demonstrated the existence of contraction and transition phenomena that changed the structure of neonol molecules at n ∼ 9 from a zigzag to a meander form.
|
|
