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Search: WFRF:(Arneberg D.)

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1.
  • Bergvall, Nils, et al. (author)
  • First detection of Lyman continuum escape from a local starburst galaxy. I. Observations of the luminous blue compact galaxy Haro 11 with the Far Ultraviolet Spectroscopic Explorer (FUSE)
  • 2006
  • In: Astronomy & Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 448:513
  • Journal article (peer-reviewed)abstract
    • Context: The dominating reionization source in the young universe has not yet been identified. Possible candidates include metal poor dwarf galaxies with starburst properties.Aims. We selected an extreme starburst dwarf, the Blue Compact Galaxy Haro 11, with the aim of determining the Lyman continuum escape fraction from UV spectroscopy.Methods. Spectra of Haro 11 were obtained with the Far Ultraviolet Spectroscopic Explorer (FUSE). A weak signal shortwards of the Lyman break is identified as Lyman continuum (LyC) emission escaping from the ongoing starburst. From profile fitting to weak metal lines we derive column densities of the low ionization species. Adopting a metallicity typical of the H II regions of Haro 11, these data correspond to a hydrogen column density of ~10^19cm^-2. This relatively high value indicates that most of the LyC photons escape through transparent holes in the interstellar medium. We then use spectral evolutionary models to constrain the escape fraction of the produced LyC photons.Results. Assuming a normal Salpeter initial mass function we obtain a Lyman continuum escape fraction of f_esc˜ 4-10%. We argue that in a hierarchical galaxy formation scenario, the upper limit we derive for the escape rate allows for a substantial contribution to cosmic reionization by starburst dwarf galaxies at high redshifts.
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2.
  • Trajkovska, V., et al. (author)
  • BDNF downregulates 5-HT2A receptor protein levels in hippocampal cultures
  • 2009
  • In: Neurochemistry International. - : Elsevier BV. - 0197-0186. ; 55:7, s. 697-702
  • Journal article (peer-reviewed)abstract
    • Both brain-derived neurotrophic factor (BDNF) and the serotonin receptor 2A (5-HT2A) have been related to depression pathology. Specific 5-HT2A receptor changes seen in BDNF conditional mutant mice suggest that BDNF regulates the 5-HT2A receptor level. Here we show a direct effect of BDNF on 5-HT2A receptor protein levels in primary hippocampal neuronal and mature hippocampal organotypic cultures exposed to different BDNF concentrations for either 1, 3, 5 or 7 days. In vivo effects of BDNF on hippocampal 5-HT2A receptor levels were further corroborated in (BDNF +/-) mice with reduced BDNF levels. In primary neuronal cultures, 7 days exposure to 25 and 50 ng/mL BDNF resulted in downregulation of 5-HT2A, but not of 5-HT1A, receptor protein levels. The BDNF-associated downregulation of 5-HT2A receptor levels was also observed in mature hippocampal organotypic cultures, excluding confounding effects of BDNF on immature tissue. BDNF +/- mice showed significant increased 5-HT2A receptor levels in hippocampus confirming the association between 5-HT2A receptor and BDNF levels in vivo. In conclusion, our results point to a regulatory role of BDNF on 5-HT2A receptor levels. This interaction may be an important mechanism in the role of BDNF in affective disorders emphasizing the need for further elucidating the specificity and the mechanism behind this regulation. (C) 2009 Elsevier Ltd. All rights reserved.
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