| 1. |
- Kanai, M, et al.
(author)
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- 2023
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swepub:Mat__t
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| 2. |
- Gonzalez Caceres, Alex Arnoldo, 1982, et al.
(author)
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Application and validation of a method to assess the energy reduction and environmental impact of renovation alternatives
- 2023
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In: IOP Conference Series: Earth and Environmental Science. - 1755-1307 .- 1755-1315. ; 1196:1
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Conference paper (peer-reviewed)abstract
- The renovation of residential stock is one of the most promising areas, in terms of energy reduction, because these buildings are highly inefficient and represent the largest part of the building stock. However, the environmental impact assessment over the life cycle of building renovation is rare. It is more common to develop an assessment for new buildings. This study presents a method that combines the evaluation of the benefits of renovating residential buildings, considering cost, energy and environmental benefits using Life Cycle Assessment (LCA). The method is based on 3 stages of development. First, the database of energy certificates, costs and LCA was analysed. The second step is to develop a workflow in Rhino/Grasshopper/E-Plus to automatically model a residential building and feed the simulation model with the data obtained from the databases. Finally, a simulation campaign was carried out to obtain an optimal renovation package, minimising energy consumption and environmental impact. The research was carried out in a case study in Uddevalla, Sweden. The residential building has different measurements including energy consumption data before and after renovation. This was used to validate the proposed methodology. The validation shows that accurate results are achievable with potential for mass application.
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| 3. |
- Thorell, Kaisa, 1983, et al.
(author)
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The Helicobacter pylori Genome Project: insights into H. pylori population structure from analysis of a worldwide collection of complete genomes
- 2023
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In: Nature Communications. - 2041-1723. ; 14:1
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Journal article (peer-reviewed)abstract
- Helicobacter pylori, a dominant member of the gastric microbiota, shares co-evolutionary history with humans. This has led to the development of genetically distinct H. pylori subpopulations associated with the geographic origin of the host and with differential gastric disease risk. Here, we provide insights into H. pylori population structure as a part of the Helicobacter pylori Genome Project (HpGP), a multi-disciplinary initiative aimed at elucidating H. pylori pathogenesis and identifying new therapeutic targets. We collected 1011 well-characterized clinical strains from 50 countries and generated high-quality genome sequences. We analysed core genome diversity and population structure of the HpGP dataset and 255 worldwide reference genomes to outline the ancestral contribution to Eurasian, African, and American populations. We found evidence of substantial contribution of population hpNorthAsia and subpopulation hspUral in Northern European H. pylori. The genomes of H. pylori isolated from northern and southern Indigenous Americans differed in that bacteria isolated in northern Indigenous communities were more similar to North Asian H. pylori while the southern had higher relatedness to hpEastAsia. Notably, we also found a highly clonal yet geographically dispersed North American subpopulation, which is negative for the cag pathogenicity island, and present in 7% of sequenced US genomes. We expect the HpGP dataset and the corresponding strains to become a major asset for H. pylori genomics.
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