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1.	Bielecki, P, et al. (author) Skin-resident innate lymphoid cells converge on a pathogenic effector state 2021 In: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 590592:78467852, s. 128- Journal article (peer-reviewed)
2.	Bielecki, P, et al. (author) YYSkin-resident innate lymphoid cells converge on a pathogenic effector state 2021 In: NATURE. - 0028-0836. ; 592:7852, s. 128- Journal article (other academic/artistic)
3.	Vesely, MCA, et al. (author) Effector TH17 Cells Give Rise to Long-Lived TRM Cells that Are Essential for an Immediate Response against Bacterial Infection 2019 In: Cell. - : Elsevier BV. - 1097-4172 .- 0092-8674. ; 178:5, s. 1176- Journal article (peer-reviewed)
4.	Xu, H, et al. (author) The induction and function of the anti-inflammatory fate of TH17 cells 2020 In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1, s. 3334- Journal article (peer-reviewed)abstract TH17 cells exemplify environmental immune adaptation: they can acquire both a pathogenic and an anti-inflammatory fate. However, it is not known whether the anti-inflammatory fate is merely a vestigial trait, or whether it serves to preserve the integrity of the host tissues. Here we show that the capacity of TH17 cells to acquire an anti-inflammatory fate is necessary to sustain immunological tolerance, yet it impairs immune protection against S. aureus. Additionally, we find that TGF-β signalling via Smad3/Smad4 is sufficient for the expression of the anti-inflammatory cytokine, IL-10, in TH17 cells. Our data thus indicate a key function of TH17 cell plasticity in maintaining immune homeostasis, and dissect the molecular mechanisms explaining the functional flexibility of TH17 cells with regard to environmental changes.

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Type of publication: journal article (4)

Type of content: peer-reviewed (3); other academic/artistic (1)

Author/Editor: Jackson, R. (4); Xu, H (4); Gagliani, N (4); Flavell, RA (4); Bielecki, P (4); Vesely, MCA (4); show more...; Licona-Limon, P (4); Bailis, W (4); Kowalczyk, MS (3); Kroehling, L (3); Zhao, J (2); Regev, A (2); Dionne, D (2); Riesenfeld, SJ (2); Hutter, JC (2); Triglia, ET (2); Ricardo-Gonzalez, RR (2); Lian, M (2); Slyper, M (2); Muus, C (2); Ludwig, LS (2); Christian, E (2); Tao, LM (2); Kedaigle, AJ (2); Steach, HR (2); York, AG (2); Skadow, MH (2); Yaghoubi, P (2); Jarret, A (2); McGee, HM (2); Porter, CBM (2); Gasteiger, G (2); Locksley, RM (2); Huber, S. (1); Izbicki, J (1); Perez, D (1); Agalioti, T (1); Pereira, JP (1); Pallis, P (1); Steglich, B (1); Geginat, J (1); Tolosa, E (1); Wahib, R (1); Iwasaki, A (1); Kluger, Y (1); Low, JS (1); Harman, CCD (1); Iijima, N (1); Pillai, PS (1); Kaplan, DH (1); show less...

University: Karolinska Institutet (4)

Language: English (4)

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