SwePub
Sök i SwePub databas

  Extended search

Träfflista för sökning "WFRF:(Baker Sara) "

Search: WFRF:(Baker Sara)

  • Result 1-10 of 64
Sort/group result
   
EnumerationReferenceCoverFind
1.
  • 2021
  • swepub:Mat__t
  •  
2.
  •  
3.
  •  
4.
  •  
5.
  • Sawcer, Stephen, et al. (author)
  • Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
  • 2011
  • In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 476:7359, s. 214-219
  • Journal article (peer-reviewed)abstract
    • Multiple sclerosis is a common disease of the central nervous system in which the interplay between inflammatory and neurodegenerative processes typically results in intermittent neurological disturbance followed by progressive accumulation of disability. Epidemiological studies have shown that genetic factors are primarily responsible for the substantially increased frequency of the disease seen in the relatives of affected individuals, and systematic attempts to identify linkage in multiplex families have confirmed that variation within the major histocompatibility complex (MHC) exerts the greatest individual effect on risk. Modestly powered genome-wide association studies (GWAS) have enabled more than 20 additional risk loci to be identified and have shown that multiple variants exerting modest individual effects have a key role in disease susceptibility. Most of the genetic architecture underlying susceptibility to the disease remains to be defined and is anticipated to require the analysis of sample sizes that are beyond the numbers currently available to individual research groups. In a collaborative GWAS involving 9,772 cases of European descent collected by 23 research groups working in 15 different countries, we have replicated almost all of the previously suggested associations and identified at least a further 29 novel susceptibility loci. Within the MHC we have refined the identity of the HLA-DRB1 risk alleles and confirmed that variation in the HLA-A gene underlies the independent protective effect attributable to the class I region. Immunologically relevant genes are significantly overrepresented among those mapping close to the identified loci and particularly implicate T-helper-cell differentiation in the pathogenesis of multiple sclerosis.
  •  
6.
  •  
7.
  •  
8.
  • Ferrari, Raffaele, et al. (author)
  • Frontotemporal dementia and its subtypes: a genome-wide association study.
  • 2014
  • In: Lancet Neurology. - 1474-4465. ; 13:7, s. 686-699
  • Journal article (peer-reviewed)abstract
    • Frontotemporal dementia (FTD) is a complex disorder characterised by a broad range of clinical manifestations, differential pathological signatures, and genetic variability. Mutations in three genes-MAPT, GRN, and C9orf72-have been associated with FTD. We sought to identify novel genetic risk loci associated with the disorder.
  •  
9.
  • Aad, G., et al. (author)
  • 2013
  • In: The European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6052. ; 73:3
  • Journal article (peer-reviewed)
  •  
10.
  •  
Skapa referenser, mejla, bekava och länka
  • Result 1-10 of 64
Type of publication
journal article (57)
research review (4)
book (1)
book chapter (1)
Type of content
peer-reviewed (62)
other academic/artistic (1)
Author/Editor
Walker, R. (42)
Jones, G. (39)
Price, D. (39)
Spagnolo, S. (39)
Young, C. (39)
Esposito, B. (38)
show more...
Li, L. (37)
Yao, L. (35)
Gao, Y. (31)
Williams, M (27)
Buchanan, J. (25)
Thomas, P. (25)
Baker, A. (25)
Lee, S (25)
Pereira, A (25)
Young, R. (25)
Sinha, A. (25)
Thomas, J. (25)
Murphy, S. (25)
Liu, Y. (24)
Kaufman, M (24)
Taylor, D (24)
Clark, M. (24)
Martin, A. (24)
Robinson, S. (24)
Day, C. (24)
Page, A. (24)
Zhang, W. (24)
West, A. (24)
Smith, P. (24)
Morris, J. (24)
Williams, J (24)
Wood, R (24)
Bowden, M. (24)
Davis, W. (24)
Afzal, M (24)
Rodrigues, P (24)
Silva, C. (24)
Duran, I (24)
Kundu, A. (24)
Lopez, J. M. (24)
Martin, Y. (24)
Cox, M (24)
Wang, N. (24)
Belli, F. (24)
Godwin, J (24)
Airila, M (24)
Albanese, R (24)
Ambrosino, G (24)
Amosov, V (24)
show less...
University
Uppsala University (42)
Royal Institute of Technology (39)
Chalmers University of Technology (26)
Lund University (23)
Stockholm University (17)
Karolinska Institutet (9)
show more...
University of Gothenburg (3)
Linnaeus University (3)
Swedish Museum of Natural History (3)
Halmstad University (1)
Örebro University (1)
Linköping University (1)
University of Borås (1)
Swedish University of Agricultural Sciences (1)
show less...
Language
English (64)
Research subject (UKÄ/SCB)
Natural sciences (48)
Engineering and Technology (12)
Medical and Health Sciences (10)
Social Sciences (6)

Year

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view