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- Aprile, E., et al.
(author)
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Physics reach of the XENON1T dark matter experiment
- 2016
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In: Journal of Cosmology and Astroparticle Physics. - : IOP Publishing. - 1475-7516. ; :4
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Journal article (peer-reviewed)abstract
- The XENON1T experiment is currently in the commissioning phase at the Laboratori Nazionali del Gran Sasso, Italy. In this article we study the experiment's expected sensitivity to the spin-independent WIMP-nucleon interaction cross section, based on Monte Carlo predictions of the electronic and nuclear recoil backgrounds. The total electronic recoil background in 1 tonne fiducial volume and (1, 12) keV electronic recoil equivalent energy region, before applying any selection to discriminate between electronic and nuclear recoils, is (1.80+/-0.15) . 10(-4) (kg.day.keV)(-1), mainly due to the decay of Rn-222 daughters inside the xenon target. The nuclear recoil background in the corresponding nuclear recoil equivalent energy region (4, 50) keV, is composed of (0.6 +/- 0.1) (t.y)(-1) from radiogenic neutrons, (1.8+/-0.3) . 10(-2) (t.y)(-1) from coherent scattering of neutrinos, and less than 0.01 (t.y)(-1) from muon-induced neutrons. The sensitivity of XENON1T is calculated with the Pro file Likelihood Ratio method, after converting the deposited energy of electronic and nuclear recoils into the scintillation and ionization signals seen in the detector. We take into account the systematic uncertainties on the photon and electron emission model, and on the estimation of the backgrounds, treated as nuisance parameters. The main contribution comes from the relative scintillation efficiency L-eff, which affects both the signal from WIMPs and the nuclear recoil backgrounds. After a 2 y measurement in 1 tonne fiducial volume, the sensitivity reaches a minimum cross section of 1.6 . 10(-47) cm(2) at m(chi) = 50 GeV/c(2).
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| 2. |
- Van Oost, G., et al.
(author)
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Turbulent transport reduction by E x B velocity shear during edge plasma biasing : recent experimental results
- 2003
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In: Plasma Physics and Controlled Fusion. - 0741-3335 .- 1361-6587. ; 45:5, s. 621-643
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Journal article (peer-reviewed)abstract
- Experiments in the tokamaks TEXTOR, CASTOR, T-10 and ISTTOK, as well as in the reversed field pinch RFX have provided new and complementary evidence on the physics of the universal mechanism of E x B velocity shear stabilization of turbulence, concomitant transport barrier formation and radial conductivity by using various edge biasing techniques. In TEXTOR the causality between transport reduction and induced electric fields in the edge has been for the first time clearly demonstrated. The high electric field gradients have been identified as the cause for the quenching of turbulent cells. A quantitative analysis of the measured transport reduction is in good agreement with theoretical predictions. The scaling of plasma turbulence suppression with velocity shear has been established, revealing the density-potential cross-phase as a key element. Reduction in poloidal electric field, temperature, and density fluctuations across the shear layer lead to a reduction of the anomalous conducted and convected heat fluxes resulting in an energy transport barrier that is measured directly. In CASTOR the biasing electrode is placed at the separatrix in a non-intrusive configuration which has demonstrated strongly sheared electric fields and consequent improvement of the global particle confinement, as predicted by theory. The impact of sheared E x B flow on edge turbulent structures has been measured directly using a comprehensive set of electrostatic probe arrays as well as emissive probes. Measurements with a full poloidal Langmuir probe array have revealed quasi-coherent electrostatic waves in the SOL with a dominant mode number equal to the edge safety factor. In T-10 edge biasing is clearly improving the global performance of ECR heated discharges. Reflectometry and heavy ion beam probe measurements show the existence of a narrow plasma layer with strong suppression of turbulence. On ISTTOK, the influence of alternating positive and negative electrode and (non-intrusive) limiter biasing has been compared. Electrode biasing is found to be more efficient in modifying the radial electric field E, and confinement, limiter biasing acting mainly on the SOL. In the RFX reversed field pinch it has been demonstrated that also in RFPs biasing can increase the local E x B velocity shear in the edge region, and hence substantially reduce the local turbulence driven particle flux mainly due to a change in the relative phase between potential and density fluctuations.
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| 6. |
- Karthick Raaj, R., et al.
(author)
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Exploring grinding and burnishing as surface post-treatment options for electron beam additive manufactured Alloy 718
- 2020
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In: Surface & Coatings Technology. - : Elsevier BV. - 0257-8972 .- 1879-3347. ; 397
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Journal article (peer-reviewed)abstract
- Numerous additive manufacturing (AM) techniques have been developed over the past decade. Features like immense freedom of intricate part design and shorter lead time make AM routes promising for a wide range of applications spanning aerospace, marine and automobile sectors. Among the various metal AM processes, Electron Beam Additive Manufacturing (EBAM) is being widely explored to realise the potential of Ni-based superalloys and Ti alloys for varied high-performance applications. A novel attempt has been made in this paper to assess the surface integrity of as-built EBAM nickel-based superalloy 718 (AB) subjected to grinding (G), Low Plasticity Burnishing (LPB) and their sequential combination. Apart from their influence on sub-surface microstructures, the effect of process variables during the above post-treatments on the residual stress profiles was also investigated. Results revealed that G + LPB results in about 0.6 ÎŒm lower surface roughness, 17% improved microhardness compared to AB + LPB, and higher compressive surface residual stress as compared to LPB processed EBAM samples. The sequential grinding and LPB - improved microhardness, was also found to extend about 500 ÎŒm more when compared to the LPB process. The G + LPB, which is greatly influenced by the prior grinding, smoothens the surface and thus results in a better surface finish. Highest hardness, superior surface finish, reduced porosity and improved compressive residual stress were observed in samples that adopted the AB + G + LPB sequence over other samples, with the LPB step at 40 MPa yielding the best results. © 2020 Elsevier B.V.
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| 8. |
- Parreiras, Lucas S., et al.
(author)
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Engineering and two-stage evolution of a lignocellulosic hydrolysate-tolerant Saccharomyces cerevisiae strain for anaerobic fermentation of xylose from AFEX pretreated corn stover
- 2014
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In: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 9:9
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Journal article (peer-reviewed)abstract
- The inability of the yeast Saccharomyces cerevisiae to ferment xylose effectively under anaerobic conditions is a major barrier to economical production of lignocellulosic biofuels. Although genetic approaches have enabled engineering of S. cerevisiae to convert xylose efficiently into ethanol in defined lab medium, few strains are able to ferment xylose from lignocellulosic hydrolysates in the absence of oxygen. This limited xylose conversion is believed to result from small molecules generated during biomass pretreatment and hydrolysis, which induce cellular stress and impair metabolism. Here, we describe the development of a xylose-fermenting S. cerevisiae strain with tolerance to a range of pretreated and hydrolyzed lignocellulose, including Ammonia Fiber Expansion (AFEX)-pretreated corn stover hydrolysate (ACSH). We genetically engineered a hydrolysate-resistant yeast strain with bacterial xylose isomerase and then applied two separate stages of aerobic and anaerobic directed evolution. The emergent S. cerevisiae strain rapidly converted xylose from lab medium and ACSH to ethanol under strict anaerobic conditions. Metabolomic, genetic and biochemical analyses suggested that a missense mutation in GRE3, which was acquired during the anaerobic evolution, contributed toward improved xylose conversion by reducing intracellular production of xylitol, an inhibitor of xylose isomerase. These results validate our combinatorial approach, which utilized phenotypic strain selection, rational engineering and directed evolution for the generation of a robust S. cerevisiae strain with the ability to ferment xylose anaerobically from ACSH.
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| 9. |
- Snowden, JA, et al.
(author)
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Benchmarking of survival outcomes following haematopoietic stem cell transplantation: A review of existing processes and the introduction of an international system from the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE)
- 2020
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In: Bone marrow transplantation. - : Springer Science and Business Media LLC. - 1476-5365 .- 0268-3369. ; 55:4, s. 681-694
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Journal article (peer-reviewed)abstract
- In many healthcare settings, benchmarking for complex procedures has become a mandatory requirement by competent authorities, regulators, payers and patients to assure clinical performance, cost-effectiveness and safe care of patients. In several countries inside and outside Europe, benchmarking systems have been established for haematopoietic stem cell transplantation (HSCT), but access is not universal. As benchmarking is now integrated into the FACT-JACIE standards, the EBMT and JACIE established a Clinical Outcomes Group (COG) to develop and introduce a universal system accessible across EBMT members. Established systems from seven European countries (United Kingdom, Italy, Belgium, France, Germany, Spain, Switzerland), USA and Australia were appraised, revealing similarities in process, but wide variations in selection criteria and statistical methods. In tandem, the COG developed the first phase of a bespoke risk-adapted international benchmarking model for one-year survival following allogeneic and autologous HSCT based on current capabilities within the EBMT registry core dataset. Data completeness, which has a critical impact on validity of centre comparisons, is also assessed. Ongoing development will include further scientific validation of the model, incorporation of further variables (when appropriate) alongside implementation of systems for clinically meaningful interpretation and governance aiming to maximise acceptance to centres, clinicians, payers and patients across EBMT.
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