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Enumeration	Reference	Cover	Find
1.	2017 swepub:Mat__t
2.	Jukema, JW, et al. (author) Alirocumab in Patients With Polyvascular Disease and Recent Acute Coronary Syndrome: ODYSSEY OUTCOMES Trial 2019 In: Journal of the American College of Cardiology. - : Elsevier BV. - 1558-3597 .- 0735-1097. ; 74:9, s. 1167-1176 Journal article (peer-reviewed)
3.	Ray, KK, et al. (author) Effects of alirocumab on cardiovascular and metabolic outcomes after acute coronary syndrome in patients with or without diabetes: a prespecified analysis of the ODYSSEY OUTCOMES randomised controlled trial 2019 In: The lancet. Diabetes & endocrinology. - 2213-8595 .- 2213-8587. ; 7:8, s. 618-628 Journal article (peer-reviewed)
4.	Roe, MT, et al. (author) Risk Categorization Using New American College of Cardiology/American Heart Association Guidelines for Cholesterol Management and Its Relation to Alirocumab Treatment Following Acute Coronary Syndromes 2019 In: Circulation. - : Ovid Technologies (Wolters Kluwer Health). - 1524-4539 .- 0009-7322. ; 140:19, s. 1578-1589 Journal article (peer-reviewed)
5.	Szarek, M, et al. (author) Alirocumab Reduces Total Hospitalizations and Increases Days Alive and Out of Hospital in the ODYSSEY OUTCOMES Trial 2019 In: Circulation. Cardiovascular quality and outcomes. - : Ovid Technologies (Wolters Kluwer Health). - 1941-7705 .- 1941-7713. ; 12:11, s. e005858- Journal article (peer-reviewed)
6.	Szarek, M, et al. (author) Alirocumab Reduces Total Nonfatal Cardiovascular and Fatal Events: The ODYSSEY OUTCOMES Trial 2019 In: Journal of the American College of Cardiology. - : Elsevier BV. - 1558-3597 .- 0735-1097. ; 73:4, s. 387-396 Journal article (peer-reviewed)
7.	Bittner, VA, et al. (author) Effect of Alirocumab on Lipoprotein(a) and Cardiovascular Risk After Acute Coronary Syndrome 2020 In: Journal of the American College of Cardiology. - : Elsevier BV. - 1558-3597 .- 0735-1097. ; 75:2, s. 133-144 Journal article (peer-reviewed)
8.	Goodman, SG, et al. (author) Effects of Alirocumab on Cardiovascular Events After Coronary Bypass Surgery 2019 In: Journal of the American College of Cardiology. - : Elsevier BV. - 1558-3597 .- 0735-1097. ; 74:9, s. 1177-1186 Journal article (peer-reviewed)
9.	Schwartz, GG, et al. (author) Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome 2018 In: The New England journal of medicine. - : MASSACHUSETTS MEDICAL SOC. - 1533-4406 .- 0028-4793. ; 379:22, s. 2097-2107 Journal article (peer-reviewed)
10.	Marouli, Eirini, et al. (author) Rare and low-frequency coding variants alter human adult height 2017 In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 542:7640, s. 186-190 Journal article (peer-reviewed)abstract Height is a highly heritable, classic polygenic trait with approximately 700 common associated variants identified through genome-wide association studies so far. Here, we report 83 height-associated coding variants with lower minor-allele frequencies (in the range of 0.1-4.8%) and effects of up to 2 centimetres per allele (such as those in IHH, STC2, AR and CRISPLD2), greater than ten times the average effect of common variants. In functional follow-up studies, rare height increasing alleles of STC2 (giving an increase of 1-2 centimetres per allele) compromised proteolytic inhibition of PAPP-A and increased cleavage of IGFBP-4 in vitro, resulting in higher bioavailability of insulin-like growth factors. These 83 height-associated variants overlap genes that are mutated in monogenic growth disorders and highlight new biological candidates (such as ADAMTS3, IL11RA and NOX4) and pathways (such as proteoglycan and glycosaminoglycan synthesis) involved in growth. Our results demonstrate that sufficiently large sample sizes can uncover rare and low-frequency variants of moderate-to-large effect associated with polygenic human phenotypes, and that these variants implicate relevant genes and pathways.

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Result 1-10 of 134

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Type of publication: journal article (98); conference paper (25); research review (6); book (1); editorial proceedings (1); other publication (1); show more...; book chapter (1); show less...

Type of content: peer-reviewed (102); other academic/artistic (31)

Author/Editor: Hofman-Bang, C (22); Bang-Andersen, B (21); Halldin, C (20); Farde, L (19); Finnema, SJ (15); Spaak, J. (13); show more...; Tornvall, P (12); Gulyas, B (12); Agewall, S (11); Henareh, L (11); Collste, O (11); Schwartz, M. (10); Daniel, M. (10); Hagström, Emil (10); Bang, LE (10); Robinson, S. (9); Zheng, Y. (9); Das, S. (9); Diaz, R. (9); Mahajan, A. (9); Diaz, A. (9); Aboyans, V (9); Takahashi, T. (9); Katz, A. (9); Anderson, J (9); Scott, D. (9); Jukema, JW (9); Kim, C. (9); Jernberg, T (9); Ferrari, E. (9); Park, H. (9); Collins, N (9); Larsen, J (9); Takeda, Y (9); Sakamoto, T. (9); Leclercq, F. (9); White, L (9); Adamkova, V. (9); Yusoff, K. (9); Garrido, M (9); de Silva, HA (9); Hunter, J (9); Bhatt, DL (9); Malhotra, V. (9); Rasmanis, G (9); Shaw, J (9); Steg, PG (9); Galvani, M (9); Sinnaeve, P (9); Alings, M (9); show less...

University: Karolinska Institutet (94); Uppsala University (29); Umeå University (12); Linköping University (12); Lund University (12); University of Gothenburg (9); show more...; Örebro University (3); Mid Sweden University (3); Stockholm University (2); Stockholm School of Economics (2); Royal Institute of Technology (1); Luleå University of Technology (1); Chalmers University of Technology (1); Swedish Museum of Natural History (1); show less...

Language: English (133); Swedish (1)

Research subject (UKÄ/SCB): Medical and Health Sciences (51); Natural sciences (9); Social Sciences (5)

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