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- 2019
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Journal article (peer-reviewed)
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- Zicha, S., et al.
(author)
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Comparative analytical performance of multiple plasma A beta 42 and A beta 40 assays and their ability to predict positron emission tomography amyloid positivity
- 2022
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In: Alzheimers & Dementia. - : Wiley. - 1552-5260 .- 1552-5279.
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Journal article (peer-reviewed)abstract
- Introduction This report details the approach taken to providing a dataset allowing for analyses on the performance of recently developed assays of amyloid beta (A beta) peptides in plasma and the extent to which they improve the prediction of amyloid positivity. Methods Alzheimer's Disease Neuroimaging Initiative plasma samples with corresponding amyloid positron emission tomography (PET) data were run on six plasma A beta assays. Statistical tests were performed to determine whether the plasma A beta measures significantly improved the area under the receiver operating characteristic curve for predicting amyloid PET status compared to age and apolipoprotein E (APOE) genotype. Results The age and APOE genotype model predicted amyloid status with an area under the curve (AUC) of 0.75. Three assays improved AUCs to 0.81, 0.81, and 0.84 (P < .05, uncorrected for multiple comparisons). Discussion Measurement of A beta in plasma contributes to addressing the amyloid component of the ATN (amyloid/tau/neurodegeneration) framework and could be a first step before or in place of a PET or cerebrospinal fluid screening study. Highlights The Foundation of the National Institutes of Health Biomarkers Consortium evaluated six plasma amyloid beta (A beta) assays using Alzheimer's Disease Neuroimaging Initiative samples. Three assays improved prediction of amyloid status over age and apolipoprotein E (APOE) genotype. Plasma A beta 42/40 predicted amyloid positron emission tomography status better than A beta 42 or A beta 40 alone.
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| 3. |
- Bannon, Brittany L., et al.
(author)
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Confirmatory factor analysis of illness behavior in the Swedish Adoption/Twin Study of Aging (SATSA)
- 2017
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In: Annals of Behavioral Medicine. - : Springer. - 0883-6612 .- 1532-4796. ; 51:Suppl. 1, s. S2654-S2655
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Journal article (peer-reviewed)abstract
- Background: Illness behaviors—or affective, cognitive, and behavioral responses to symptoms of illness—predict patient outcomes, including symptom exacerbation and functional recovery, and they account for a large proportion of U.S. healthcare costs. Although priorcross-sectional work has examined illness behaviors like symptom reporting in isolation, the measurement of illness behavior using a longitudinal, multi-indicator approach has yet to be explored.Aim: We evaluated illness behavior as a latent, developmental construct in the Swedish Adoption/Twin Study of Aging (SATSA).Method: Participants were up to 1,886 individuals (from 1,223 twin pairs) ages 29 to 102 years (Mage baseline = 62.32 years; SD =13.69; 59% Female). Illness behavior indicators included somatic complaints, non-prescription medication use, pain-related disability and perceived illness complications. The psychomotor retardation subscale of the CES-D was used to index somatic complaints, and medication use was a simple composite of 9 dichotomous items on participants’ use of non-prescription medications, such as over-the-counter analgesics, in the previous month. Pain-related disability included a simple composite of three dichotomous items on the presence of neck,back, or shoulder pain that prevented participants from performing daily tasks or activities. Perceived illness disability was a composite of difference scores, calculated from subtracting a physician panel’s objective ratings of disability for each of 35 medical conditions (on a 3-pointscale; 1= Little or no disability; 3= Severe disability) from participants’ self-ratings of how much each of the same endorsed medical conditions interfered with their daily lives (on the same 3-point scale; 1= Not at all; 3= A lot). Positive composite scores reflected higher perceived disability relative to what was expected from the objective ratings, whereas a composite score of zero reflected “accuracy” or agreement in perceived illness complications. Confirmatory Factor Analysis (CFA) was used to evaluate invariance in the loadings of these four indicatorson a latent illness behavior factor across four questionnaire waves (1987-2004).Findings: Confirmatory factor analyses revealed moderate factor loadings of the four indicators (standardized loadings ranged from .49 to .52, all ps < .0001). Also, practical fit indices from the nested model comparisons suggested strong factorial invariance in the loadings across time (CFI = .96; TLI = .95, RMSEA= .03, 90% CI: [.026, .035]).Conclusion: Illness behavior as a latent, multi-indicator construct represents a promising focus for longitudinal work on behavior change and maintenance.
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| 6. |
- Ciolfi, L., et al.
(author)
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The Shannon Portal Installation : Interaction Design for public spaces
- 2007
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In: IEEE Computer Society. - : IEEE Computer Society. - 1051-4651. ; 40:7, s. 64-71
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Journal article (peer-reviewed)abstract
- The portal dolmen project at Ireland's Shannon airport tackled the challenges of a public exhibition and revealed the importance of focusing on situated activities as well as the crucial need for incorporating physical and aesthetic concerns into the design.
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| 7. |
- Ciolfi, L., et al.
(author)
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The Shannon Portal Installation: An Example of Interaction Design for Public Places
- 2007
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In: IEEE Computer Society. - : IEEE Communications Society. - 1051-4651. ; , s. 65-72
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Journal article (peer-reviewed)abstract
- The portal dolmen project at Ireland's Shannon airport tackled the challenges of a public exhibition and revealed the importance of focusing on situated activities as well as the crucial need for incorporating physical and aesthetic concerns into the design.
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| 9. |
- Bannon, L., et al.
(author)
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Hybrid design creates innovative, museum experiences
- 2005
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In: Communications of the ACM. - : Association for Computing Machinery (ACM). - 0001-0782 .- 1557-7317. ; 48:3, s. 62-65
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Journal article (peer-reviewed)abstract
- Museums which rely on simple text panels for providing information to visitors about museum artifacts are discussed. The study involved extensive fieldwork, audio-visual recording, interviews and discussion with curators, museum, educators and exhibit designers. The radio frequency identification (RFID)-tagged paper enabled visitors to assemble a coherent experience from their interactions with different installations. It is suggested that ubiquitous technologies should be assembled and combined with other media to form a interactive and collaborative systems in the museum.
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- Deshpande, Parag
(author)
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Bringing an interactive artefact into being : Examining the use of an architectural design model in interaction design
- 2009
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Doctoral thesis (other academic/artistic)abstract
- This thesis examines the use of an architectural design model in interaction design and provides a detailed and concrete account of bringing an interactive artefact, the Recipe Station, into being.The model of architectural design, with its view of the activity of design as envisioning and making incorporates a number of design traditions that allows architects to deal with novel challenges in an effective and efficient manner. It is argued that the prevalent model of architectural design can provide a more coherent and richer framework for the activity of interaction design than is currently the case.This model of architectural design is illuminated by the author’s reflection on design research carried out in traditional design disciplines as well as his own experience in the professional practice of architecture. The model of architectural design, thus illuminated, is then evaluated by applying it to bring an interactive artefact, the Recipe Station, into being.This thesis demonstrates that the model of architectural design offers a number of advantages for interaction design activity.The account of bringing an interactive artefact discussed in this thesis illustrates a process or morphology of the activity of reflective design that can be applied to interaction design (Schön, 1983).The thesis also illuminates a number of design traditions associated with a architectural design practice, such as, study of design cases, a solution-focused approach to the process of problem formulation, and a ‘design by drawing’ approach, that can offer significant advantages for the activity of interaction design.This thesis, thus, introduces a way of thinking about the activity of design which is driven by the design skills of the designer and makes contributions to interaction design research.
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