1. |
- Campbell, PJ, et al.
(author)
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Pan-cancer analysis of whole genomes
- 2020
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In: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 578:7793, s. 82-
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Journal article (peer-reviewed)abstract
- Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale1–3. Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4–5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter4; identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation5,6; analyses timings and patterns of tumour evolution7; describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity8,9; and evaluates a range of more-specialized features of cancer genomes8,10–18.
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2. |
- Abe, K., et al.
(author)
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J-PARC Neutrino Beamline Upgrade Technical Design Report
- 2019
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Reports (peer-reviewed)abstract
- In this document, technical details of the upgrade plan of the J-PARC neutrino beamline for the extension of the T2K experiment are described. T2K has proposed to accumulate data corresponding to 2×1022 protons-on-target in the next decade, aiming at an initial observation of CP violation with 3σ or higher significance in the case of maximal CP violation. Methods to increase the neutrino beam intensity, which are necessary to achieve the proposed data increase, are described.
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3. |
- Abreu, P, et al.
(author)
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A measurement of alpha(s) from the scaling violation in e(+)e(-) annihilation
- 1997
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In: PHYSICS LETTERS B. - : ELSEVIER SCIENCE BV. - 0370-2693. ; 398:1-2, s. 194-206
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Journal article (other academic/artistic)abstract
- The hadronic fragmentation functions of the various quark flavours and of gluons are measured in a study of the inclusive hadron production from Z(0) decays with the DELPHI detector and are compared with the fragmentation functions measured elsewhere at e
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4. |
- Abreu, P, et al.
(author)
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A precise measurement of the B-d(0) meson lifetime using a new technique
- 1997
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In: ZEITSCHRIFT FUR PHYSIK C-PARTICLES AND FIELDS. - : SPRINGER VERLAG. - 0170-9739. ; 74:1, s. 19-32
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Journal article (other academic/artistic)abstract
- From data recorded by DELPHI between 1991 and 1994, which corresponds to 3.2 million hadronic Z(0) decays, a measurement of the <(B-d(0))over bar> meson lifetime, based on the inclusive reconstruction of 3520 +/- 150 semileptonic decays of the type <(B-d(
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5. |
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6. |
- Abreu, P, et al.
(author)
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An upper limit for Br(Z(0)->ggg) from symmetric 3-jet Z(0) hadronic decays
- 1996
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In: PHYSICS LETTERS B. - : ELSEVIER SCIENCE BV. - 0370-2693. ; 389:2, s. 405-415
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Journal article (other academic/artistic)abstract
- An upper limit for BR(Z(0) --> 3g) is obtained from a correlation method, which distinguishes statistically between quark and gluon jets by using the difference in their charged particle multiplicity distributions. From the sample of threefold symmetric t
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7. |
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8. |
- Abreu, P, et al.
(author)
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First study of the interference between initial and final state radiation at the Z resonance
- 1996
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In: ZEITSCHRIFT FUR PHYSIK C-PARTICLES AND FIELDS. - : SPRINGER VERLAG. - 0170-9739. ; 72:1, s. 31-38
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Journal article (other academic/artistic)abstract
- The interference between initial and final state radiation in the process e(+)e(-) --> mu(+)mu(-) at root s approximate to M(Z) has been studied by measuring the forward-backward asymmetry as a function of the acoplanarity angle between the final state mu
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9. |
- Abreu, P, et al.
(author)
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Identified particles in quark and gluon jets
- 1997
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In: PHYSICS LETTERS B. - : ELSEVIER SCIENCE BV. - 0370-2693. ; 401:1-2, s. 118-130
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Journal article (other academic/artistic)abstract
- A sample of about 1.4 million hadronic Z decays, selected among the data recorded by the DELPHI detector at LEP during 1994, was used to measure for the first time the momentum spectra of K+, K-0, p, Lambda and their antiparticles in gluon and quark jets.
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10. |
- Abreu, P, et al.
(author)
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Kaon interference in the hadronic decays of the Z(0)
- 1996
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In: PHYSICS LETTERS B. - : ELSEVIER SCIENCE BV. - 0370-2693. ; 379:1-4, s. 330-340
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Journal article (other academic/artistic)abstract
- The first measurement of like-sign charged kaon correlations in hadronic decays of the Z(0) is presented, based on data collected by the DELPHI detector. The charged kaons are identified by means of ring imaging Cherenkov detectors. A significant enhancem
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