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Träfflista för sökning "WFRF:(Barnfield C) "

Search: WFRF:(Barnfield C)

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  • Hjorth, R., Leijon, P., Barnfield-Frej, A.-K., and Jägersten, C. (author)
  • Expanded bed adsorption chromatography
  • 1998
  • In: G. Subramanian, (ed.), Bioseparation and Bioprocessing. - : Wiley-VCH, Weinheim. ; , s. 199-226
  • Book chapter (other academic/artistic)
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  • Nordstrom, EKL, et al. (author)
  • Enhanced immunogenicity using an alphavirus replicon DNA vaccine against human immunodeficiency virus type 1
  • 2005
  • In: The Journal of general virology. - : Microbiology Society. - 0022-1317 .- 1465-2099. ; 86:Pt 2, s. 349-354
  • Journal article (peer-reviewed)abstract
    • With the human immunodeficiency virus type 1 (HIV-1) epidemic expanding at increasing speed, development of a safe and effective vaccine remains a high priority. One of the most central vaccine platforms considered is plasmid DNA. However, high doses of DNA and several immunizations are typically needed to achieve detectable T-cell responses. In this study, a Semliki Forest virus replicon DNA vaccine designed for human clinical trials, DREP.HIVA, encoding an antigen that is currently being used in human trials in the context of a conventional DNA plasmid, pTHr.HIVA, was generated. It was shown that a single immunization of DREP.HIVA stimulated HIV-1-specific T-cell responses in mice, suggesting that the poor immunogenicity of conventional DNA vaccines may be enhanced by using viral replicon-based plasmid systems. The results presented here support the evaluation of Semliki Forest virus replicon DNA vaccines in non-human primates and in clinical studies.
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