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1.	Apelqvist, A, et al. (author) Notch signalling controls pancreatic cell differentiation 1999 In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 400:6747, s. 877-881 Journal article (peer-reviewed)
2.	Beatus, P, et al. (author) Notch and neurogenesis 1998 In: Journal of neuroscience research. - 0360-4012. ; 54:2, s. 125-136 Journal article (peer-reviewed)
3.	Beatus, P, et al. (author) The notch 3 intracellular domain represses notch 1-mediated activation through Hairy/Enhancer of split (HES) promoters 1999 In: Development (Cambridge, England). - : The Company of Biologists. - 0950-1991 .- 1477-9129. ; 126:17, s. 3925-3935 Journal article (peer-reviewed)abstract The Notch signaling pathway is important for cellular differentiation. The current view is that the Notch receptor is cleaved intracellularly upon ligand activation. The intracellular Notch domain then translocates to the nucleus, binds to Suppressor of Hairless (RBP-Jk in mammals), and acts as a transactivator of Enhancer of Split (HES in mammals) gene expression. In this report we show that the Notch 3 intracellular domain (IC), in contrast to all other analysed Notch ICs, is a poor activator, and in fact acts as a repressor by blocking the ability of the Notch 1 IC to activate expression through the HES-1 and HES-5 promoters. We present a model in which Notch 3 IC interferes with Notch 1 IC-mediated activation at two levels. First, Notch 3 IC competes with Notch 1 IC for access to RBP-Jk and does not activate transcription when positioned close to a promoter. Second, Notch 3 IC appears to compete with Notch 1 IC for a common coactivator present in limiting amounts. In conclusion, this is the first example of a Notch IC that functions as a repressor in Enhancer of Split/HES upregulation, and shows that mammalian Notch receptors have acquired distinct functions during evolution.
4.	Beatus, P, et al. (author) The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity 2001 In: Mechanisms of development. - : Elsevier BV. - 0925-4773. ; 104:1-2, s. 3-20 Journal article (peer-reviewed)
5.	Krebs, LT, et al. (author) Characterization of Notch3-deficient mice: normal embryonic development and absence of genetic interactions with a Notch1 mutation 2003 In: Genesis (New York, N.Y. : 2000). - : Wiley. - 1526-954X .- 1526-968X. ; 37:3, s. 139-143 Journal article (peer-reviewed)
6.	Lendahl, U, et al. (author) Diversity in Notch intracellular functions: Implications for CADASIL 2000 In: EUROPEAN JOURNAL OF NEUROSCIENCE. - 0953-816X. ; 12, s. 514-514 Conference paper (other academic/artistic)
7.	Reynaud-Deonauth, S, et al. (author) Notch signaling is involved in the regulation of Id3 gene transcription during Xenopus embryogenesis 2002 In: Differentiation. - : Elsevier BV. - 0301-4681. ; 69:4-5, s. 198-208 Journal article (peer-reviewed)

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Type of publication: journal article (6); conference paper (1)

Type of content: peer-reviewed (6); other academic/artistic (1)

Author/Editor: Beatus, P (7); Lendahl, U (5); Lundkvist, J (2); Oberg, C (2); Li, H. (1); Zhang, H. (1); show more...; aut (1); Pedersen, K (1); Edlund, H. (1); Prakash, N (1); Apelqvist, A (1); Sommer, L (1); Anderson, DJ (1); Honjo, T (1); de Angelis, MH (1); Joutel, A (1); Krebs, LT (1); Xue, YZ (1); Norton, CR (1); Sundberg, JP (1); Gridley, T (1); Reynaud-Deonauth, S (1); Afouda, A (1); Taillefert, S (1); Kloc, M (1); Etkin, LD (1); Fischer-Lougheed, J (1); Spohr, G (1); show less...

University: Karolinska Institutet (7)

Language: English (7)

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