| 1. |
- Azinas, Stavros, et al.
(author)
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D-strand perturbation and amyloid propensity in beta-2 microglobulin
- 2011
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In: The FEBS Journal. - : John Wiley & Sons. - 1742-464X .- 1742-4658. ; 278:13, s. 2349-58
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Journal article (peer-reviewed)abstract
- Proteins hosting main β-sheets adopt specific strategies to avoid intermolecular interactions leading to aggregation and amyloid deposition. Human beta-2 microglobulin (β2m) displays a typical immunoglobulin fold and is known to be amyloidogenic in vivo. Upon severe kidney deficiency, β2m accumulates in the bloodstream, triggering, over the years, pathological deposition of large amyloid aggregates in joints and bones. A β-bulge observed on the edge D β-strand of some β2m crystal structures has been suggested to be crucial in protecting the protein from amyloid aggregation. Conversely, a straight D-strand, observed in different crystal structures of monomeric β2m, could promote amyloid aggregation. More recently, the different conformations observed for the β2m D-strand have been interpreted as the result of intrinsic flexibility, rather than being assigned to a functional protective role against aggregation. To shed light on such contrasting picture, the mutation Asp53→Pro was engineered in β2m, aiming to impair the formation of a regular/straight D-strand. Such a mutant was characterized structurally and biophysically by CD, X-ray crystallography and MS, in addition to an assessment of its amyloid aggregation trends in vitro. The results reported in the present study highlight the conformational plasticity of the edge D-strand, and show that even perturbing the D-strand structure through a Pro residue has only marginal effects on protecting β2m from amyloid aggregation in vitro.
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| 2. |
- Bellotti, Francesco, et al.
(author)
-
Alessandro De Gloria-1955-2023
- 2023
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In: INTERNATIONAL JOURNAL OF SERIOUS GAMES. - : Serious Games Society. - 2384-8766. ; 10:1, s. 2-3
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Journal article (other academic/artistic)
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| 3. |
- Curceanu, Catalina, et al.
(author)
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X-ray detectors for kaonic atoms research at DAΦNE
- 2019
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In: Condensed Matter. - : MDPI AG. - 2410-3896. ; 4:2
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Journal article (peer-reviewed)abstract
- This article presents the kaonic atom studies performed at the INFN National Laboratory of Frascati (Laboratori Nazionali di Frascati dell’INFN, LNF-INFN) since the opening of this field of research at the DAΦNE collider in early 2000. Significant achievements have been obtained by the DAΦNE Exotic Atom Research (DEAR) and Silicon Drift Detector for Hadronic Atom Research by Timing Applications (SIDDHARTA) experiments on kaonic hydrogen, which have required the development of novel X-ray detectors. The 2019 installation of the new SIDDHARTA-2 experiment to measure kaonic deuterium for the first time has been made possible by further technological advances in X-ray detection.
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| 4. |
- De Rosa, Francesca, et al.
(author)
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Introduction to the Special Issue on GaLA Conf 2021
- 2022
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In: INTERNATIONAL JOURNAL OF SERIOUS GAMES. - : Serious Games Society. - 2384-8766. ; 9:3, s. 3-4
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Journal article (other academic/artistic)abstract
- This is a short introduction pecial issue of the International Journal of Serious Games dedicated to the selected best papers of the 2021 edition of the Games and Learning (GALA) 2021 conference. The three selected papers have undergone a regular review process. Covered topics range from cooperative games to mixed reality, from digital companions to game co-design.
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| 5. |
- de Rosa, Francesca, et al.
(author)
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Preface
- 2021
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In: Proceedings 10th International Conference on Games and Learning Alliance, GALA 2021. - : Springer Nature.
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Conference paper (other academic/artistic)
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| 6. |
- Hauge, Jannicke, et al.
(author)
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ANALYSIS ON EDUCATING MECHANICAL ENGINEERS THROUGH SERIOUS GAMES USING PERVASIVE TECHNOLOGIES
- 2016
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In: PROCEEDINGS OF THE ASME INTERNATIONAL DESIGN ENGINEERING TECHNICAL CONFERENCES AND COMPUTERS AND INFORMATION IN ENGINEERING CONFERENCE, 2016, VOL 1B. - : AMER SOC MECHANICAL ENGINEERS.
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Conference paper (peer-reviewed)abstract
- In the education of mechanical engineers alternative learning methods like serious games, simulations etc. have been used in past decades to better the learning outcomes. However, as digital technologies advance, so too does the quality of commercial game-based learning. This brings the expectation that while serious games are still considered as an experimental pedagogic vehicle, the learning experience among students and their experience of using serious games become heightened. This is a challenge for several educational games that though fully able to progress a learning goal, is deemed detached due to its dated user interface and inability to host the latest ICTs. This creates an unappealing aspect to the student and can also affect their motivation. This paper reports on the early efforts to analyze serious games from the perspective of learning and gaming mechanics and the virtual environment and systems that can be made pervasive. The intention is to re-furbish dated serious games that are highly relevant to. educating mechanical engineers. The proposed concepts lie in the adoption of new pervasive technologies enabled by cyber-physical systems (CPS) and Internet of things (IoT) to modernize dated engineering serious games.
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| 7. |
- Hiller, Johannes, et al.
(author)
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The L3Pilot Data Management Toolchain for a Level 3 Vehicle Automation Pilot
- 2020
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In: Electronics (Switzerland). - : MDPI AG. - 2079-9292. ; 9:5
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Journal article (peer-reviewed)abstract
- As industrial research in automated driving is rapidly advancing, it is of paramount importance to analyze field data from extensive road tests. This paper investigates the design and development of a toolchain to process and manage experimental data to answer a set of research questions about the evaluation of automated driving functions at various levels, from technical system functioning to overall impact assessment. We have faced this challenge in L3Pilot, the first comprehensive test of automated driving functions (ADFs) on public roads in Europe. L3Pilot is testing ADFs in vehicles made by 13 companies. The tested functions are mainly of Society of Automotive Engineers (SAE) automation level 3, some of them of level 4. In this context, the presented toolchain supports various confidentiality levels, and allows cross-vehicle owner seamless data management, with the efficient storage of data and their iterative processing with a variety of analysis and evaluation tools. Most of the toolchain modules have been developed to a prototype version in a desktop/cloud environment, exploiting state-of-the-art technology. This has allowed us to efficiently set up what could become a comprehensive edge-to-cloud reference architecture for managing data in automated vehicle tests. The project has been released as open source, the data format into which all vehicular signals, recorded in proprietary formats, were converted, in order to support efficient processing through multiple tools, scalability and data quality checking. We expect that this format should enhance research on automated driving testing, as it provides a shared framework for dealing with data from collection to analysis. We are confident that this format, and the information provided in this article, can represent a reference for the design of future architectures to implement in vehicles.
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| 8. |
- Oliveri, Matteo, et al.
(author)
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Designing an IoT-focused, Multiplayer Serious Game for Industry 4.0 Innovation
- 2019
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In: 2019 IEEE INTERNATIONAL CONFERENCE ON ENGINEERING, TECHNOLOGY AND INNOVATION (ICE/ITMC). - : IEEE. - 9781728134017 - 9781728134024
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Conference paper (peer-reviewed)abstract
- There is a trend in industries towards adoption of new technologies coming from Industry 4.0 to improve operational automation, efficiency, maintenance, by interconnecting sensors, devices, machines, and processes, increasing data availability for automation and decision support. These changing scenarios need to be addressed also in terms of instruction and training, for students, workers and stakeholders. In this paper, we explore as a case study the design of a Serious Game aimed at preparing undergraduate students to understand and cope with such new concepts, tools and practices, with a focus on the Internet of Things.
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| 9. |
- Tibaldi, Alberto, et al.
(author)
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Analysis of Carrier Transport in Tunnel-Junction Vertical-Cavity Surface-Emitting Lasers by a Coupled Nonequilibrium Green's Function-Drift-Diffusion Approach
- 2020
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In: Physical Review Applied. - 2331-7019. ; 14:2
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Journal article (peer-reviewed)abstract
- This work investigates carrier transport in tunnel junctions for vertical-cavity surface-emitting lasers (VCSELs). The study is performed with a quantum-corrected semiclassical approach, where tunneling is described rigorously with a nonequilibrium Green's function formalism based on a multiband description of the electronic structure. Validated with experimental results, the proposed approach provides a quantum -kinetic perspective of the tunneling process and paves the way toward a comprehensive theory of VCSELs, bridging the gap between semiclassical and quantum simulations.
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| 10. |
- Tibaldi, Alberto, et al.
(author)
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Modeling Tunnel Junctions for VCSELs: A Self-Consistent NEGF-DD Approach
- 2020
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In: Proceedings of the International Conference on Numerical Simulation of Optoelectronic Devices, NUSOD. - 2158-3234. ; 2020-September, s. 67-68
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Conference paper (peer-reviewed)abstract
- In this work we investigate carrier transport in tunnel junctions for vertical-cavity surface-emitting lasers by a novel self-consistent simulation framework for semiconductor quantum devices. Based on a Poisson-drift-diffusion foundation, in this approach quantum features are described through a nonequilibrium Green's function formalism. The simulator is validated through a comparison with experimental results.
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