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| 2. |
- Benn, Jette, et al.
(author)
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Efterord
- 2015. - 1
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In: Barn, mat och måltider. - Malmö : Gleerups Utbildning AB. ; , s. 159-163
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Book chapter (other academic/artistic)
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| 3. |
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| 4. |
- Janhonen, Kristiina, et al.
(author)
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Company and meal choices considered by Nordic adolescents
- 2013
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In: International Journal of Consumer Studies. - : Wiley. - 1470-6423 .- 1470-6431. ; 37:6, s. 587-595
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Journal article (peer-reviewed)abstract
- This article examines the meal choices considered by Nordic adolescents in two social situations: for themselves and for the family. In addition, the frequency of family meals is compared between the countries studied. The survey data (n = 1539) were collected during 2006–2007 from 9th grade students (aged 14–17 years) in Finland, Sweden, Denmark and Norway. Analysis was based on both quantitative variables and open-ended data. Family meals were found to be less common among Finnish respondents than in the remaining data. In all countries but Denmark, the number of parents in the family had an effect on the frequency of family meals. Meals echoing or fully meeting the structural definition of a ‘proper meal’ were most common when describing meals for the family. The difference between the two social situations was most apparent for those who mentioned ‘Fast food dishes’ for themselves. Gender differences in open-ended questions were smallest in Denmark and most apparent in Norway. Future studies should focus not only on how many of adolescents eat in what is termed an unhealthy way but also on how they themselves perceive and conceptualize eating, and what kinds of justifications they give to their everyday choices in different social contexts.
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| 5. |
- Kainulainen, Kristiina, et al.
(author)
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Nordic adolescents´school lunch patterns and their suggestions for making healthy choices at school easier
- 2012
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In: Appetite. - : Elsevier BV. - 0195-6663 .- 1095-8304. ; 59:1, s. 53-62
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Journal article (peer-reviewed)abstract
- This article examines Nordic adolescents’ school lunch patterns and their perceptions of how making healthy choices at school could be easier. Analysis is based on a quantitative data-set collected between 2006 and 2007 as part of a Nordic research project. The sample of 1539 respondents consisted of 14–17 year old adolescents from Finland, Sweden, Denmark, and Norway. The number of adolescents regularly eating either a packed lunch or a hot school lunch differed between countries and statistically significant differences were found between girls’ and boys’ school lunch patterns in the Swedish and Finnish data. Results suggest that adolescents have an understanding of what is healthy, but that school resources do not always support their ability to make healthy choices. Adolescents’ own suggestions for improvement imply that more attention should be paid to building a healthy school food environment. An important future challenge is trying to involve school health care personnel and aligning classroom activities more coherently with adolescents’ eating patterns during the school day.
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| 6. |
- Marouli, Eirini, et al.
(author)
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Rare and low-frequency coding variants alter human adult height
- 2017
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 542:7640, s. 186-190
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Journal article (peer-reviewed)abstract
- Height is a highly heritable, classic polygenic trait with approximately 700 common associated variants identified through genome-wide association studies so far. Here, we report 83 height-associated coding variants with lower minor-allele frequencies (in the range of 0.1-4.8%) and effects of up to 2 centimetres per allele (such as those in IHH, STC2, AR and CRISPLD2), greater than ten times the average effect of common variants. In functional follow-up studies, rare height increasing alleles of STC2 (giving an increase of 1-2 centimetres per allele) compromised proteolytic inhibition of PAPP-A and increased cleavage of IGFBP-4 in vitro, resulting in higher bioavailability of insulin-like growth factors. These 83 height-associated variants overlap genes that are mutated in monogenic growth disorders and highlight new biological candidates (such as ADAMTS3, IL11RA and NOX4) and pathways (such as proteoglycan and glycosaminoglycan synthesis) involved in growth. Our results demonstrate that sufficiently large sample sizes can uncover rare and low-frequency variants of moderate-to-large effect associated with polygenic human phenotypes, and that these variants implicate relevant genes and pathways.
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| 7. |
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| 8. |
- Turcot, Valerie, et al.
(author)
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Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
- 2018
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In: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 50:1, s. 26-41
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Journal article (peer-reviewed)abstract
- Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters of common, noncoding variants from which pinpointing causal genes remains challenging. Here we combined data from 718,734 individuals to discover rare and low-frequency (minor allele frequency (MAF) < 5%) coding variants associated with BMI. We identified 14 coding variants in 13 genes, of which 8 variants were in genes (ZBTB7B, ACHE, RAPGEF3, RAB21, ZFHX3, ENTPD6, ZFR2 and ZNF169) newly implicated in human obesity, 2 variants were in genes (MC4R and KSR2) previously observed to be mutated in extreme obesity and 2 variants were in GIPR. The effect sizes of rare variants are similar to 10 times larger than those of common variants, with the largest effect observed in carriers of an MC4R mutation introducing a stop codon (p.Tyr35Ter, MAF = 0.01%), who weighed similar to 7 kg more than non-carriers. Pathway analyses based on the variants associated with BMI confirm enrichment of neuronal genes and provide new evidence for adipocyte and energy expenditure biology, widening the potential of genetically supported therapeutic targets in obesity.
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