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Träfflista för sökning "WFRF:(Berg Göran) "

Search: WFRF:(Berg Göran)

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  • Boij, Roland, et al. (author)
  • Biomarkers of Coagulation, Inflammation, and Angiogenesis are Independently Associated with Preeclampsia
  • 2012
  • In: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY. - : John Wiley and Sons. - 1046-7408 .- 8755-8920. ; 68:3, s. 258-270
  • Journal article (peer-reviewed)abstract
    • Problem Although preeclampsia has been associated with inflammation, coagulation, and angiogenesis, their correlation and relative contribution are unknown. Method of Study About 114 women with preeclampsia, 31 with early onset (EOP) and 83 with late onset preeclampsia (LOP), and 100 normal pregnant controls were included. A broad panel of 32 biomarkers reflecting coagulation, inflammation, and angiogenesis was analyzed. Results Preeclampsia was associated with decreased antithrombin, IL-4 and placental growth factor levels and with increased C3a, pentraxin-3, and sFlt-1 levels, with more marked differences in the EOP group. The Th1-associated chemokines CXCL10 and CXCL11 were significantly higher in the preeclampsia and EOP group than in controls, respectively. No correlations between the biomarkers were found in preeclampsia. Multivariate logistic regression tests confirmed the results. Conclusions Cytokines, chemokines and complement activation seem to be part of a Th1-like inflammatory reaction in preeclampsia, most pronounced in EOP, where chemokines may be more useful than cytokines as biomarkers. Biomarkers were not correlated suggesting partly independent or in time separated mechanisms.
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  • Sampson, Joshua N., et al. (author)
  • Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types
  • 2015
  • In: Journal of the National Cancer Institute. - : Oxford University Press (OUP). - 0027-8874 .- 1460-2105. ; 107:12
  • Journal article (peer-reviewed)abstract
    • Background: Studies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites. Methods: Between 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cancers, and the genetic correlation between pairs of cancers. Results: GWAS heritability was statistically significant at nearly all sites, with the estimates of array-based heritability, h(l)(2), on the liability threshold (LT) scale ranging from 0.05 to 0.38. Estimating the combined heritability of multiple smoking characteristics, we calculate that at least 24% (95% confidence interval [CI] = 14% to 37%) and 7% (95% CI = 4% to 11%) of the heritability for lung and bladder cancer, respectively, can be attributed to genetic determinants of smoking. Most pairs of cancers studied did not show evidence of strong genetic correlation. We found only four pairs of cancers with marginally statistically significant correlations, specifically kidney and testes (rho = 0.73, SE = 0.28), diffuse large B-cell lymphoma (DLBCL) and pediatric osteosarcoma (rho = 0.53, SE = 0.21), DLBCL and chronic lymphocytic leukemia (CLL) (rho = 0.51, SE = 0.18), and bladder and lung (rho = 0.35, SE = 0.14). Correlation analysis also indicates that the genetic architecture of lung cancer differs between a smoking population of European ancestry and a nonsmoking Asian population, allowing for the possibility that the genetic etiology for the same disease can vary by population and environmental exposures. Conclusion: Our results provide important insights into the genetic architecture of cancers and suggest new avenues for investigation.
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  • Svanberg, Sune, et al. (author)
  • Applications of terawatt lasers
  • 1994
  • In: LASER SPECTROSCOPY - XITH INTERNATIONAL CONFERENCE. - : AIP. - 1551-7616 .- 0094-243X. - 1563962624 ; :290, s. 264-269
  • Conference paper (peer-reviewed)
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  • Result 1-10 of 215
Type of publication
journal article (148)
conference paper (27)
doctoral thesis (12)
other publication (10)
reports (8)
research review (4)
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editorial collection (3)
book chapter (1)
licentiate thesis (1)
patent (1)
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Type of content
peer-reviewed (163)
other academic/artistic (45)
pop. science, debate, etc. (7)
Author/Editor
Berg, Göran (69)
Ernerudh, Jan (49)
Jenmalm, Maria (33)
Matthiesen, Leif (24)
Berg, Göran, 1946- (18)
Ekerfelt, Christina (16)
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Riboli, Elio (11)
Sharma, Surendra (11)
Kraft, Peter (11)
Hunter, David J (11)
Chanock, Stephen J (10)
Svensson-Arvelund, J ... (10)
Haiman, Christopher ... (9)
Canzian, Federico (9)
Hallmans, Göran (9)
Hoover, Robert N. (9)
Swietlicki, Erik (9)
Frank, Göran (9)
Kolonel, Laurence N (9)
Mjösberg, Jenny (9)
Albanes, Demetrius (8)
Berg, Marie, 1955 (8)
Bueno-de-Mesquita, H ... (8)
Gaziano, J Michael (8)
Hankinson, Susan E (8)
Ernerudh, Jan, 1952- (8)
Kaaks, Rudolf (7)
Jenab, Mazda (7)
Sydsjö, Gunilla (7)
Trichopoulos, Dimitr ... (7)
Shu, Xiao-Ou (7)
Zheng, Wei (7)
Le Marchand, Loïc (7)
Duell, Eric J. (7)
Hammar, Mats (7)
Yu, Kai (7)
Blomqvist, Anders (7)
Olson, Sara H. (7)
Berg, Christine D (7)
Bracci, Paige M (7)
Holly, Elizabeth A (7)
Hutchinson, Amy (7)
Kooperberg, Charles (7)
Kurtz, Robert C (7)
Li, Donghui (7)
Risch, Harvey A (7)
Wolpin, Brian M (7)
Zeleniuch-Jacquotte, ... (7)
Berg, Sture, 1939 (7)
Malmgren, Sven-Göran ... (7)
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University
Linköping University (93)
University of Gothenburg (38)
Lund University (28)
Uppsala University (27)
Umeå University (19)
Karolinska Institutet (19)
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Stockholm University (11)
Royal Institute of Technology (9)
Linnaeus University (9)
Swedish University of Agricultural Sciences (7)
Kristianstad University College (6)
Örebro University (6)
Chalmers University of Technology (5)
Mid Sweden University (4)
University of Borås (3)
Halmstad University (1)
Jönköping University (1)
University of Skövde (1)
RISE (1)
Swedish National Heritage Board (1)
Karlstad University (1)
Högskolan Dalarna (1)
VTI - The Swedish National Road and Transport Research Institute (1)
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Language
English (190)
Swedish (25)
Research subject (UKÄ/SCB)
Medical and Health Sciences (61)
Natural sciences (42)
Social Sciences (21)
Engineering and Technology (12)
Humanities (11)
Agricultural Sciences (3)

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