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Träfflista för sökning "WFRF:(Bergman Lars) "

Search: WFRF:(Bergman Lars)

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  • Bergman, Olle, 1978, et al. (author)
  • Do polymorphisms in transcription factors LMX1A and LMX1B influence the risk for Parkinson's disease?
  • 2009
  • In: Journal of neural transmission (Vienna, Austria : 1996). - : Springer Science and Business Media LLC. - 1435-1463 .- 0300-9564. ; 116:3, s. 333-8
  • Journal article (peer-reviewed)abstract
    • The key symptoms of Parkinson's disease (PD) are caused by degeneration of dopamine neurons originating in substantia nigra. Whereas, transcription factor LMX1A is crucial for the differentiation of mesencephalic dopamine neurons, LMX1B appears to be important for both the development and the survival of these cells. The aim of this study was to investigate if genetic variation in LMX1A and LMX1B differs between patients with PD (n = 357) and control subjects (n = 1428) by genotyping 33 single nucleotide polymorphisms (SNPs) in LMX1A and 11 SNPs in LMX1B. Three SNPs in LMX1A and one in LMX1B were associated with PD. After splitting for gender, six SNPs were associated with PD in women and four in men. The significances obtained did not survive correction for multiple testing, and our results should hence be interpreted with caution, but are partly in line with a previous report, and should thus be of sufficient interest to encourage further studies of these genes in PD.
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  • Kaufmann, Tobias, et al. (author)
  • Common brain disorders are associated with heritable patterns of apparent aging of the brain
  • 2019
  • In: Nature Neuroscience. - : Nature Publishing Group. - 1097-6256 .- 1546-1726. ; 22:10, s. 1617-
  • Journal article (peer-reviewed)abstract
    • Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3-96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.
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  • Alnaes, Dag, et al. (author)
  • Brain Heterogeneity in Schizophrenia and Its Association With Polygenic Risk
  • 2019
  • In: JAMA psychiatry. - : AMER MEDICAL ASSOC. - 2168-6238 .- 2168-622X. ; 76:7, s. 739-748
  • Journal article (peer-reviewed)abstract
    • ImportanceBetween-individual variability in brain structure is determined by gene-environment interactions, possibly reflecting differential sensitivity to environmental and genetic perturbations. Magnetic resonance imaging (MRI) studies have revealed thinner cortices and smaller subcortical volumes in patients with schizophrenia. However, group-level comparisons may mask considerable within-group heterogeneity, which has largely remained unnoticed in the literature. ObjectivesTo compare brain structural variability between individuals with schizophrenia and healthy controls and to test whether respective variability reflects the polygenic risk score (PRS) for schizophrenia in an independent sample of healthy controls. Design, Setting, and ParticipantsThis case-control and polygenic risk analysis compared MRI-derived cortical thickness and subcortical volumes between healthy controls and patients with schizophrenia across 16 cohorts and tested for associations between PRS and MRI features in a control cohort from the UK Biobank. Data were collected from October 27, 2004, through April 12, 2018, and analyzed from December 3, 2017, through August 1, 2018. Main Outcomes and MeasuresMean and dispersion parameters were estimated using double generalized linear models. Vertex-wise analysis was used to assess cortical thickness, and regions-of-interest analyses were used to assess total cortical volume, total surface area, and white matter, subcortical, and hippocampal subfield volumes. Follow-up analyses included within-sample analysis, test of robustness of the PRS threshold, population covariates, outlier removal, and control for image quality. ResultsA comparison of 1151 patients with schizophrenia (mean [SD] age,33.8[10.6] years; 68.6% male [n=790] and 31.4% female [n=361]) with 2010 healthy controls (mean [SD] age,32.6[10.4] years; 56.0% male [n=1126] and 44.0% female [n=884]) revealed higher heterogeneity in schizophrenia for cortical thickness and area (t = 3.34), cortical (t=3.24) and ventricle (t range, 3.15-5.78) volumes, and hippocampal subfields (t range, 2.32-3.55). In the UK Biobank sample of 12 490 participants (mean [SD] age,55.9 [7.5] years; 48.2% male [n=6025] and 51.8% female [n=6465]), higher PRS was associated with thinner frontal and temporal cortices and smaller left CA2/3 (t=-3.00) but was not significantly associated with dispersion. Conclusions and RelevanceThis study suggests that schizophrenia is associated with substantial brain structural heterogeneity beyond the mean differences. These findings may reflect higher sensitivity to environmental and genetic perturbations in patients, supporting the heterogeneous nature of schizophrenia. A higher PRS was associated with thinner frontotemporal cortices and smaller hippocampal subfield volume, but not heterogeneity. This finding suggests that brain variability in schizophrenia results from interactions between environmental and genetic factors that are not captured by the PRS. Factors contributing to heterogeneity in frontotemporal cortices and hippocampus are key to furthering our understanding of how genetic and environmental factors shape brain biology in schizophrenia.
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  • Result 1-10 of 448
Type of publication
journal article (303)
conference paper (39)
reports (28)
other publication (26)
doctoral thesis (23)
book chapter (18)
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book (5)
editorial collection (3)
research review (2)
licentiate thesis (1)
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Type of content
peer-reviewed (328)
other academic/artistic (108)
pop. science, debate, etc. (12)
Author/Editor
Bergman, Lars R. (49)
Bergman, Anders (44)
Nordström, Lars (32)
Eriksson, Olle (30)
Lind, Lars (28)
Bergman, Lars (24)
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Bergqvist, Lars (20)
Groop, Leif (19)
Lyssenko, Valeriya (15)
Milberg, Per (15)
Boehnke, Michael (15)
Ingelsson, Erik (15)
Tuomilehto, Jaakko (15)
Bergman, Karl-Olof (15)
Chico, Jonathan (15)
Westerberg, Lars (15)
Jackson, Anne U. (15)
Wareham, Nicholas J. (14)
Laakso, Markku (14)
McCarthy, Mark I (14)
Langenberg, Claudia (14)
Mohlke, Karen L (14)
Barroso, Ines (14)
Bergman, Anders, 197 ... (14)
Prokopenko, Inga (14)
Eriksson, Olle, 1960 ... (13)
Kuusisto, Johanna (13)
Dupuis, Josée (13)
Meigs, James B. (13)
Eriksson, Lars (12)
Tuomi, Tiinamaija (11)
Salomaa, Veikko (11)
Cervenka, Simon (11)
Gieger, Christian (11)
Froguel, Philippe (11)
Fatouros-Bergman, He ... (11)
Kovacs, Peter (11)
Bergqvist, Lars, 197 ... (11)
Delin, Anna (11)
Bonnycastle, Lori L. (11)
Nilsson, Peter (10)
Bergman, Michael (10)
Bergman, Åke (10)
Mahajan, Anubha (10)
Walker, Mark (10)
Gustafsson, Stefan (10)
Palmer, Colin N. A. (10)
Morris, Andrew D (10)
Frayling, Timothy M (10)
Chines, Peter S. (10)
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University
Uppsala University (147)
Stockholm University (82)
Lund University (71)
Karolinska Institutet (69)
Linköping University (46)
Umeå University (45)
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Royal Institute of Technology (43)
University of Gothenburg (37)
Chalmers University of Technology (28)
Örebro University (25)
Halmstad University (22)
Karlstad University (20)
Luleå University of Technology (11)
Jönköping University (10)
Linnaeus University (10)
Swedish University of Agricultural Sciences (10)
Stockholm School of Economics (9)
Södertörn University (9)
Mid Sweden University (8)
Mälardalen University (6)
Högskolan Dalarna (5)
VTI - The Swedish National Road and Transport Research Institute (5)
University of Gävle (3)
University of Skövde (3)
The Swedish School of Sport and Health Sciences (3)
RISE (3)
University of Borås (2)
Malmö University (1)
Swedish Environmental Protection Agency (1)
Swedish National Heritage Board (1)
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Language
English (388)
Swedish (51)
Undefined language (6)
Latin (3)
Research subject (UKÄ/SCB)
Natural sciences (141)
Social Sciences (127)
Medical and Health Sciences (107)
Engineering and Technology (41)
Humanities (12)
Agricultural Sciences (6)

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