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1.	Fergusson, J. R., et al. (author) CD161(int)CD8+T cells : a novel population of highly functional, memory CD8+T cells enriched within the gut 2016 In: Mucosal Immunology. - : Elsevier BV. - 1933-0219 .- 1935-3456. ; 9:2, s. 401-413 Journal article (peer-reviewed)abstract The C-type lectin-like receptor CD161 is expressed by lymphocytes found in human gut and liver, as well as blood, especially natural killer (NK) cells, T helper 17 (Th17) cells, and a population of unconventional Tcells known as mucosalassociated invariant T (MAIT) cells. The association of high CD161 expression with innate T-cell populations including MAITcells is established. Here we show that CD161 is also expressed, at intermediate levels, on a prominent subset of polyclonal CD8+ T cells, including antiviral populations that display a memory phenotype. These memory CD161(int)CD8+ Tcells are enriched within the colon and express both CD103 and CD69, markers associated with tissue residence. Furthermore, this population was characterized by enhanced polyfunctionality, increased levels of cytotoxic mediators, and high expression of the transcription factors T-bet and eomesodermin (EOMES). Such populations were induced by novel vaccine strategies based on adenoviral vectors, currently in trial against hepatitis C virus. Thus, intermediate CD161 expression marks potent polyclonal, polyfunctional tissue-homing CD8+ T-cell populations in humans. As induction of such responses represents a major aim of T-cell prophylactic and therapeutic vaccines in viral disease and cancer, analysis of these populations could be of value in the future.
2.	Balasiddaiah, A, et al. (author) Hepatitis C Virus-Specific T Cell Receptor mRNA-Engineered Human T Cells: Impact of Antigen Specificity on Functional Properties 2017 In: Journal of virology. - 1098-5514. ; 91:9 Journal article (peer-reviewed)
3.	Bertoletti, L, et al. (author) "Rehab for all!" Is it too early in pulmonary arterial hypertension? 2019 In: The European respiratory journal. - 1399-3003. ; 54:5 Journal article (other academic/artistic)
4.	Gwozdz, AM, et al. (author) Development of an international standard set of outcome measures for patients with venous thromboembolism: an International Consortium for Health Outcomes Measurement consensus recommendation 2022 In: The Lancet. Haematology. - 2352-3026. ; 9:9, s. e698-e706 Journal article (peer-reviewed)
5.	Gwozdz, AM, et al. (author) Development of an international standard set of outcome measures for patients with venous thromboembolism: an International Consortium for Health Outcomes Measurement consensus recommendation 2022 In: The Lancet. Haematology. - 2352-3026. ; 9:9, s. E698-E706 Journal article (peer-reviewed)
6.	Koh, S, et al. (author) A practical approach to immunotherapy of hepatocellular carcinoma using T cells redirected against hepatitis B virus 2013 In: Molecular therapy. Nucleic acids. - : Elsevier BV. - 2162-2531. ; 2, s. e114- Journal article (peer-reviewed)

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Result 1-6 of 6

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Type of publication: journal article (6)

Type of content: peer-reviewed (5); other academic/artistic (1)

Author/Editor: Bertoletti, A (3); Bertoletti, L (3); Tromeur, C (3); Ay, C. (2); Sallberg, M (2); Cohen, AT (2); show more...; Koh, S (2); Robert-Ebadi, H. (2); Campana, D. (1); Chen, M (1); Frelin, L (1); Aleman, S (1); Humbert, M. (1); Davanian, H (1); Sverremark-Ekström, ... (1); Renia, L (1); Powrie, F (1); Pison, C. (1); Balasiddaiah, A (1); Pasetto, A (1); Lohmann, V (1); Hupin, D (1); Labeix, P (1); Costes, F (1); Bouvaist, H (1); Bezzeghoud, S (1); Dauphin, C (1); Enache, I (1); Bourdin, A (1); Seronde, MF (1); Montani, D (1); Turquier, S (1); Degano, B (1); Ballereau, SC (1); Accassat, S (1); De Magalhaes, E (1); Croisille, P (1); Noirclerc, M (1); Tresorier, R (1); Couturaud, F (1); Gut-Gobert, C (1); Cottin, V (1); Traclet, J (1); Lamoureux, S (1); Strasbourg, CD (1); Riou, M (1); Canuet, M (1); Schuller, A (1); Lonsdorfer, E (1); Roux, PM (1); show less...

University: Karolinska Institutet (5); Stockholm University (1)

Language: English (6)

Research subject (UKÄ/SCB): Natural sciences (1); Medical and Health Sciences (1)

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