| 1. |
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| 2. |
- Sime, Wondossen, et al.
(author)
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Discovery of epi-enprioline as a novel drug for the treatment of vincristine resistant neuroblastoma
- 2020
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In: International Journal of Molecular Sciences. - : MDPI AG. - 1661-6596 .- 1422-0067. ; 21:18
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Journal article (peer-reviewed)abstract
- Neuroblastoma is a childhood solid tumour originating from undifferentiated neural progenitor cells of the sympathetic nervous system. Drug resistance of childhood cancer neuroblastoma is a serious clinical problem. In the present study, we aimed to identify novel drugs that can inhibit the growth and survival of chemoresistant neuroblastoma. High-throughput screening identified a small molecule, epi-enprioline that was able to induce apoptosis of vincristine-resistant neuroblastoma cells via the mitochondrial apoptotic pathway. Epi-enprioline reduced tumour growth in multiple preclinical models, including an orthotopic neuroblastoma patient-derived xenograft model in vivo. In summary, our data suggest that epi-enprioline can be considered as a lead compound for the treatment of vincristine-resistant neuroblastoma uncovering a novel strategy, which can be further explored as a treatment for drug-resistant neuroblastoma.
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| 3. |
- Aaltonen, Kristina, et al.
(author)
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Patient-derived models : Advanced tools for precision medicine in neuroblastoma
- 2023
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In: Frontiers in Oncology. - : Frontiers Media SA. - 2234-943X. ; 12
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Journal article (peer-reviewed)abstract
- Neuroblastoma is a childhood cancer derived from the sympathetic nervous system. High-risk neuroblastoma patients have a poor overall survival and account for ~15% of childhood cancer deaths. There is thus a need for clinically relevant and authentic models of neuroblastoma that closely resemble the human disease to further interrogate underlying mechanisms and to develop novel therapeutic strategies. Here we review recent developments in patient-derived neuroblastoma xenograft models and in vitro cultures. These models can be used to decipher mechanisms of metastasis and treatment resistance, for drug screening, and preclinical drug testing. Patient-derived neuroblastoma models may also provide useful information about clonal evolution, phenotypic plasticity, and cell states in relation to neuroblastoma progression. We summarize current opportunities for, but also barriers to, future model development and application. Integration of patient-derived models with patient data holds promise for the development of precision medicine treatment strategies for children with high-risk neuroblastoma.
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| 4. |
- Allaoui, Roni, et al.
(author)
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Cancer-associated fibroblast-secreted CXCL16 attracts monocytes to promote stroma activation in triple-negative breast cancers
- 2016
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7
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Journal article (peer-reviewed)abstract
- Triple-negative (TN) breast cancers (ER â ' PR â ' HER2 â ') are highly metastatic and associated with poor prognosis. Within this subtype, invasive, stroma-rich tumours with infiltration of inflammatory cells are even more aggressive. The effect of myeloid cells on reactive stroma formation in TN breast cancer is largely unknown. Here, we show that primary human monocytes have a survival advantage, proliferate in vivo and develop into immunosuppressive myeloid cells expressing the myeloid-derived suppressor cell marker S100A9 only in a TN breast cancer environment. This results in activation of cancer-associated fibroblasts and expression of CXCL16, which we show to be a monocyte chemoattractant. We propose that this migratory feedback loop amplifies the formation of a reactive stroma, contributing to the aggressive phenotype of TN breast tumours. These insights could help select more suitable therapies targeting the stromal component of these tumours, and could aid prediction of drug resistance.
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| 5. |
- Almstedt, Elin, 1988-, et al.
(author)
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Integrative discovery of treatments for high-risk neuroblastoma
- 2020
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723 .- 2041-1723. ; 11:1
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Journal article (peer-reviewed)abstract
- Despite advances in the molecular exploration of paediatric cancers, approximately 50% of children with high-risk neuroblastoma lack effective treatment. To identify therapeutic options for this group of high-risk patients, we combine predictive data mining with experimental evaluation in patient-derived xenograft cells. Our proposed algorithm, TargetTranslator, integrates data from tumour biobanks, pharmacological databases, and cellular networks to predict how targeted interventions affect mRNA signatures associated with high patient risk or disease processes. We find more than 80 targets to be associated with neuroblastoma risk and differentiation signatures. Selected targets are evaluated in cell lines derived from high-risk patients to demonstrate reversal of risk signatures and malignant phenotypes. Using neuroblastoma xenograft models, we establish CNR2 and MAPK8 as promising candidates for the treatment of high-risk neuroblastoma. We expect that our method, available as a public tool (targettranslator.org), will enhance and expedite the discovery of risk-associated targets for paediatric and adult cancers.
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| 6. |
- Askander, Mikael, et al.
(author)
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Joel Ohlsson
- 2017
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In: En lundensisk litteraturhistoria : Lunds universitet som litterärt kraftfält - Lunds universitet som litterärt kraftfält. - 9789170612503 ; , s. 339-339
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Book chapter (pop. science, debate, etc.)abstract
- A portrait of the swedish film critic, poet and novelist Joel Ohlsson.
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| 7. |
- Askander, Mikael, et al.
(author)
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Miranda Landen
- 2017
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In: En lundensisk litteraturhistoria : Lunds universitet som litterärt kraftfält - Lunds universitet som litterärt kraftfält. - 1401-1301. - 9789170612503
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Book chapter (pop. science, debate, etc.)abstract
- A portrait of the swedish poet and critic Miranda Landén.
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| 8. |
- Back, Jon, 1977-, et al.
(author)
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the Quest : An Escape Room Inspired Interactive Museum Exhibition
- 2019
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In: CHI PLAY '19 Extended Abstracts. - New York, NY, USA : ACM Digital Library. ; , s. 81-86
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Conference paper (peer-reviewed)abstract
- In this project, we report on designing an interactive museum exhibit in a technology museum, inspired by escape room game mechanics and technology. The project aims to create a deeper more immersed engagement with and interest in the exhibition, and thereby increase the interest in the exhibit's subject. In the game, the players take on the role of grandchildren to a known (fictitious) turn-of-the-century explorer and set out to find the treasures she hid around the world during her years of adventure. Clues to the treasures are hidden within the museum exhibition and by using knowledge found around the exhibition the players can solve the riddles and find the treasure, while also picking up some knowledge along the way.
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| 9. |
- Bengtsson, Bengt Olle, et al.
(author)
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Bengt Lidforss 1868-1913
- 2017
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In: En lundensisk litteraturhistoria. : Lunds universitet som litterärt kraftfält - Lunds universitet som litterärt kraftfält. - 9789170612503 ; , s. 146-151
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Book chapter (pop. science, debate, etc.)
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| 10. |
- Bengtsson, Bengt Olle, et al.
(author)
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Åke Gustafsson 1908-1988
- 2017
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In: En lundensisk litteraturhistoria. : Lunds universitet som litterärt kraftfält - Lunds universitet som litterärt kraftfält. - 9789170612503 ; , s. 239-240
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Book chapter (pop. science, debate, etc.)
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