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- Allesøe, Rosa Lundbye, et al.
(author)
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Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models
- 2023
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In: Nature Biotechnology. - : Springer Nature. - 1087-0156 .- 1546-1696. ; 41:3, s. 399-408
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Journal article (peer-reviewed)abstract
- The application of multiple omics technologies in biomedical cohorts has the potential to reveal patient-level disease characteristics and individualized response to treatment. However, the scale and heterogeneous nature of multi-modal data makes integration and inference a non-trivial task. We developed a deep-learning-based framework, multi-omics variational autoencoders (MOVE), to integrate such data and applied it to a cohort of 789 people with newly diagnosed type 2 diabetes with deep multi-omics phenotyping from the DIRECT consortium. Using in silico perturbations, we identified drug–omics associations across the multi-modal datasets for the 20 most prevalent drugs given to people with type 2 diabetes with substantially higher sensitivity than univariate statistical tests. From these, we among others, identified novel associations between metformin and the gut microbiota as well as opposite molecular responses for the two statins, simvastatin and atorvastatin. We used the associations to quantify drug–drug similarities, assess the degree of polypharmacy and conclude that drug effects are distributed across the multi-omics modalities.
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- Andersson, David, 1979, et al.
(author)
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DN Debatt: LRF och Svenskt flyg svarar inte om klimatmålen
- 2015
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In: Dagens Nyheter. - 1101-2447.
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Journal article (pop. science, debate, etc.)abstract
- Sammantaget ser vi inget i motdebattörernas argument som talar emot att införa styrmedel, till exempel konsumtionsskatter, inom dessa områden där inga stora tekniska lösningar finns i sikte, skriver 14 miljö- och energiforskare i slutrepliken till sin text om flyg- och köttskatt (26/2).
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- Andersson, David, 1979, et al.
(author)
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Nu krävs kraftfulla åtgärder mot nötkött och flygresor
- 2015
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In: Dagens Nyheter. - 1101-2447. ; 2015-02-27
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Journal article (other academic/artistic)abstract
- Svenskarnas globala utsläpp från köttkonsumtion och flygresor motsvarar hälften av de totala utsläppen på hemmaplan. I vår rapport till Naturvårdsverket föreslår vi tydliga styrmedel – som nya skatter – för att begränsa konsumtionen på dessa områden, skriver 14 miljö- och energiforskare.
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- Andersson, Maria, 1977, et al.
(author)
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Effects of stock investments of information about short versus long price series
- 2012
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In: Review of behavioral finance. - : Emerald. - 1940-5979. ; 4:2, s. 81-97
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Journal article (peer-reviewed)abstract
- Purpose – The purpose of this paper is to investigate whether stock price predictions and investment decisions improve by exposure to increasing price series. Design/methodology/approach – The authors conducted three laboratory experiments in which undergraduates were asked to role-play being investors buying and selling stock shares. Their task was to predict an unknown closing price from an opening price and to choose the number of stocks to purchase to the opening price (risk aversion) or the closing price (risk taking). In Experiment 1 stock prices differed in volatility for increasing, decreasing or no price trend. Prices were in different conditions provided numerically for 15 trading days, for the last 10 trading days, or for the last five trading days. In Experiment 2 the price series were also visually displayed as scatter plots. In Experiment 3 the stock prices were presented for the preceding 15 days, only for each third day (five days) of the preceding 15 days, or as five prices, each aggregated for three consecutive days of the preceding 15 days. Only numerical price information was provided. Findings – The results of Experiments 1 and 2 showed that predictions were not markedly worse for shorter than longer price series. Possibly because longer price series increase information processing load, visual information had some influence to reduce prediction errors for the longer price series. The results of Experiment 3 showed that accuracy of predictions increased for less price volatility due to aggregation, whereas again there was no difference between five and 15 trading days. Purchase decisions resulted in better outcomes for the aggregated prices. Research limitations/implications – Investors´ performance in stock markets may not improve by increasing the length of evaluation intervals unless the quality of the information is also increased. The results need to be verified in actual stock markets. Practical implications – The results have bearings on the design of bonus systems. Originality/value – The paper shows how stock price predictions and buying and selling decisions depend on amount and quality of information about historical prices.
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- Andersson, Maria, 1977, et al.
(author)
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Hållbara bonussystem : Sustainable bonus systems
- 2011
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In: Hållbar utveckling - från risk till värde / L. G. Hassel, L.-O. Larsson & E. Nore (red.). - Malmö : Studentlitteratur. - 9789144075327 ; , s. 41-49
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Book chapter (other academic/artistic)
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| 8. |
- Andersson, Maria, et al.
(author)
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Hållbara bonussystem
- 2011. - 1
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In: Hållbar utveckling. - Lund : Studentlitteratur AB. - 9144075324 - 9789144075327 ; , s. 41-49
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Book chapter (other academic/artistic)
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| 10. |
- Andersson, Tobias, et al.
(author)
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On the effective constitutive properties of a thin adhesive layer loaded in peel
- 2006
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In: International Journal of Fracture. - : Springer Netherlands. - 0376-9429 .- 1573-2673. ; 141:1-2, s. 227-246
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Journal article (peer-reviewed)abstract
- An experimental method to determine the complete stress-elongation relation for a structural adhesive loaded in peel is presented. Experiments are performed on the double cantilever beam specimen, which facilitates a more stable experimental set-up as compared with conventional methods like the butt-joint test. The method is based on the concept of equilibrium of the energetic forces acting on the specimen. Two sources of energetic forces are identified: the start of the adhesive layer and the positions of the two acting loads. By use of the concept of equilibrium of energetic forces, it is possible to measure the energy release rate of the adhesive layer instantaneously during an experiment. The complete stress-elongation relation is found to be the derivative of the energy release rate with respect to the elongation of the adhesive layer at its start. By this procedure, an effective property of the adhesive layer is measured. That is, the fields are assumed to be constant through the thickness of the layer and only vary along the layer. To investigate the validity of this approach, experiments are performed on five different groups of specimens with different dimensions. This leads to large variations in the length of the damage zone at the start of the adhesive layer. Four of the experimental groups are used to determine the stress-elongation relation. This is found to be independent of the geometry. For the remaining experimental group, the adherends deform plastically and simulations are performed with the stress-elongation relation determined from the four elastic groups. It is found that the relation cannot be used to accurately predict the behaviour of the experiments where the adherends deform plastically. This indicates that the stress-elongation relation has limited applicability.
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