| 1. |
- Barausse, Enrico, et al.
(author)
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Prospects for fundamental physics with LISA
- 2020
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In: General Relativity and Gravitation. - : SPRINGER/PLENUM PUBLISHERS. - 0001-7701 .- 1572-9532. ; 52:8
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Journal article (other academic/artistic)abstract
- In this paper, which is of programmatic rather than quantitative nature, we aim to further delineate and sharpen the future potential of the LISA mission in the area of fundamental physics. Given the very broad range of topics that might be relevant to LISA,we present here a sample of what we view as particularly promising fundamental physics directions. We organize these directions through a "science-first" approach that allows us to classify how LISA data can inform theoretical physics in a variety of areas. For each of these theoretical physics classes, we identify the sources that are currently expected to provide the principal contribution to our knowledge, and the areas that need further development. The classification presented here should not be thought of as cast in stone, but rather as a fluid framework that is amenable to change with the flow of new insights in theoretical physics.
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| 2. |
- Sarmiento, S., et al.
(author)
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Redundancy, importance, and robustness analyses for damage scenarios of bridges
- 2023
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In: Life-Cycle of Structures and Infrastructure Systems - Proceedings of the 8th International Symposium on Life-Cycle Civil Engineering, IALCCE 2023. - 9781003323020 ; , s. 3904-3912
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Conference paper (peer-reviewed)abstract
- Bridges are an important part of the traffic infrastructure, which are subjected to high safety requirements and economic consequences in case of functionality failure. Therefore, it is needed to consider potentially substantial direct and indirect risks during service life, i.e., the need for risk and robustness analyses. Over the last decades, various quantitative performance criteria have been developed but their interrelation and compatibility has hardly been systematically studied. This paper contains a proposal of a novel and complementary formulation of interrelations between reliability- and risk-based robustness, importance, and redundancy indicators. The classification, derivation, and exemplification of the interrelations between these indicators are presented and formulated for two case studies of a pre-stressed concrete bridge considering different hazard scenarios namely overloading and chloride attack. The analyses and applications lead to the identification of interrelations between the reliability based robustness, redundancy and importance indicator indicators and with the risk based robustness indicator.
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| 3. |
- Biondini, S., et al.
(author)
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Strong electroweak phase transition in t-channel simplified dark matter models
- 2022
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In: Journal of Cosmology and Astroparticle Physics. - : Institute of Physics. - 1475-7516. ; 2022:10
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Journal article (peer-reviewed)abstract
- Beyond the Standard Model physics is required to explain both dark matter and the baryon asymmetry of the universe, the latter possibly generated during a strong first-order electroweak phase transition. While many proposed models tackle these problems independently, it is interesting to inquire whether the same model can explain both. In this context, we link state-of-the-art perturbative assessments of the phase transition thermodynamics with the extraction of the dark matter energy density. These techniques are applied to a next-to-minimal dark matter model containing an inert Majorana fermion that is coupled to Standard Model leptons via a scalar mediator, where the mediator interacts directly with the Higgs boson. For dark matter masses 180 GeV < M χ ≲ 300 GeV, we discern regions of the model parameter space that reproduce the observed dark matter energy density and allow for a first-order phase transition, while evading the most stringent collider constraints.
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| 4. |
- Costa, G., et al.
(author)
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On the utilization of multiple information for the integrity management of deteriorating systems
- 2023
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In: Life-Cycle of Structures and Infrastructure Systems : Proceedings of the 8th International Symposium on Life-Cycle Civil Engineering, IALCCE 2023 - Proceedings of the 8th International Symposium on Life-Cycle Civil Engineering, IALCCE 2023. - 9781003323020 ; , s. 1693-1701
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Conference paper (peer-reviewed)abstract
- Recent years’ publications have shown how valuable information can be in the integrity management of civil structures. Monitoring systems increase the knowledge about the structural state, improving the prioritization of the interventions, and the selection of optimal maintenance strategy and thereby allowing for budget optimization and risk minimization. This paper investigates the effect of multiple information on integrity management throughout a deteriorating structure’s life cycle. Pre-posterior analysis and the concept of the Value of Information (VoI) are used to quantify the benefit multiple information provide in structural integrity management. Multiple information (e.g., local information about the condition state of the several components of a system) and actions are associated with an expected utility. Optimization is performed by determining the lowest total expected cost of the maintenance strategy for a given set of information.
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| 5. |
- Iadevaia, V., et al.
(author)
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PIM1 kinase is destabilized by ribosomal stress causing inhibition of cell cycle progression
- 2010
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In: Oncogene. - : Springer Science and Business Media LLC. - 1476-5594 .- 0950-9232. ; 29:40, s. 5490-5499
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Journal article (peer-reviewed)abstract
- PIM1 is a constitutively active serine/threonine kinase regulated by cytokines, growth factors and hormones. It has been implicated in the control of cell cycle progression and apoptosis and its overexpression has been associated with various kinds of lymphoid and hematopoietic malignancies. The activity of PIM1 is dependent on the phosphorylation of several targets involved in transcription, cell cycle and apoptosis. We have recently observed that PIM1 interacts with ribosomal protein (RP) S19 and cosediments with ribosomes. Defects in ribosome synthesis (ribosomal stress) have been shown to activate a p53-dependent growth arrest response. To investigate if PIM1 could have a role in the response to ribosomal stress, we induced ribosome synthesis alterations in TF-1 and K562 erythroid cell lines. We found that RP deficiency, induced by RNA interference or treatment with inhibitor of nucleolar functions, causes a drastic destabilization of PIM1. The lower level of PIM1 induces an increase in the cell cycle inhibitor p27(Kip1) and blocks cell proliferation even in the absence of p53. Notably, restoring PIM1 level by transfection causes a recovery of cell growth. Our data indicate that PIM1 may act as a sensor for ribosomal stress independently of or in concert with the known p53-dependent mechanisms. Oncogene (2010) 29, 5490-5499; doi:10.1038/onc.2010.279; published online 19 July 2010
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