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- Bliman, S, et al.
(author)
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Collision spectroscopy of Ar8++H-2 at low velocities (upsilon < 1 a.u.)
- 1999
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In: PHYSICAL REVIEW A. - : AMERICAN PHYSICAL SOC. - 1050-2947. ; 60:4, s. 2799-2807
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Journal article (other academic/artistic)abstract
- Single and double electron transfer have been studied for the collision system Ar8++H-2 at low velocities (V<1 a.u.). X-ray ultraviolet and Auger spectroscopies complemented by translational energy gain and time-of-flight spectroscopies reveal details on
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| 9. |
- Redwan, Itedale Namro, 1981, et al.
(author)
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Towards the development of chromone-based MEK1/2 modulators
- 2014
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In: European Journal of Medicinal Chemistry. - : Elsevier BV. - 0223-5234. ; 85, s. 127-138
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Journal article (peer-reviewed)abstract
- Inhibition or allosteric modulation of mitogen-activated protein kinase kinases MEK1 and MEK2 (MEK1/2) represent a promising strategy for the discovery of new specific anticancer agents. In this paper, structure-based design, beginning from the lead compound PD98059, was used to study potential structural modifications on the chromone structure in order to obtain highly potent derivatives that target the allosteric pocket in MEK1. Subsequently, a small series of PD98059 analogs were synthesized to provide a first generation of chromone-based derivatives that inhibit the activation of MEK1 with IC50 values as low as 30 nM in vitro. Complementary cellular studies also showed that two of the compounds in the series inhibit the activity of MEK1/2 with IC50 values in the nanomolar range (73-97 nM). In addition, compounds in this series were found to inhibit the proliferation of a small panel of human cancer cell lines.
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| 10. |
- Westerlind, M., et al.
(author)
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Experimental mean-life determinations of 2p5 3p and 3d levels in S VII and Ar IX
- 1988
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In: Physica Scripta. - : IOP Publishing. - 0031-8949 .- 1402-4896. ; 38:6, s. 821-824
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Journal article (peer-reviewed)abstract
- Experimental lifetimes of several levels in the 2p5 3p and 3d configurations in Ne-like sulphur, S VII, and argon, Ar IX, have been determined by the beam-foil technique. The ANDC method for cascade correction has been applied in the analyses of the 3p decay curves. The results are generally in good agreement with recent theoretical values except for the 3p 3D levels for which significant deviations are observed. Similar discrepancies have also been observed in the isoelectronic Cl VIII system.
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