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| 2. |
- Ahlstrand, Jim, et al.
(author)
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Preliminary Results on the use of Artificial Intelligence for Managing Customer Life Cycles
- 2023
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In: 35th Annual Workshop of the Swedish Artificial Intelligence Society SAIS 2023. - : Linköping University Electronic Press. - 9789180752749 ; , s. 68-76
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Conference paper (peer-reviewed)abstract
- During the last decade we have witnessed how artificial intelligence (AI) have changed businesses all over the world. The customer life cycle framework is widely used in businesses and AI plays a role in each stage. However,implementing and generating value from AI in the customerlife cycle is not always simple. When evaluating the AI against business impact and value it is critical to consider both themodel performance and the policy outcome. Proper analysis of AI-derived policies must not be overlooked in order to ensure ethical and trustworthy AI. This paper presents a comprehensive analysis of the literature on AI in customer lifecycles (CLV) from an industry perspective. The study included 31 of 224 analyzed peer-reviewed articles from Scopus search result. The results show a significant research gap regardingoutcome evaluations of AI implementations in practice. This paper proposes that policy evaluation is an important tool in the AI pipeline and empathizes the significance of validating bothpolicy outputs and outcomes to ensure reliable and trustworthy AI.
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| 3. |
- Antoniou, A, et al.
(author)
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Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history: A combined analysis of 22 studies
- 2003
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In: American Journal of Human Genetics. - : Elsevier BV. - 0002-9297. ; 72:5, s. 1117-1130
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Journal article (peer-reviewed)abstract
- Germline mutations in BRCA1 and BRCA2 confer high risks of breast and ovarian cancer, but the average magnitude of these risks is uncertain and may depend on the context. Estimates based on multiple-case families may be enriched for mutations of higher risk and/or other familial risk factors, whereas risk estimates from studies based on cases unselected for family history have been imprecise. We pooled pedigree data from 22 studies involving 8,139 index case patients unselected for family history with female (86%) or male (2%) breast cancer or epithelial ovarian cancer (12%), 500 of whom had been found to carry a germline mutation in BRCA1 or BRCA2. Breast and ovarian cancer incidence rates for mutation carriers were estimated using a modified segregation analysis, based on the occurrence of these cancers in the relatives of mutation-carrying index case patients. The average cumulative risks in BRCA1-mutation carriers by age 70 years were 65% (95% confidence interval 44%-78%) for breast cancer and 39% (18%-54%) for ovarian cancer. The corresponding estimates for BRCA2 were 45% (31%-56%) and 11% (2.4%-19%). Relative risks of breast cancer declined significantly with age for BRCA1-mutation carriers ( P trend .0012) but not for BRCA2-mutation carriers. Risks in carriers were higher when based on index breast cancer cases diagnosed at <35 years of age. We found some evidence for a reduction in risk in women from earlier birth cohorts and for variation in risk by mutation position for both genes. The pattern of cancer risks was similar to those found in multiple-case families, but their absolute magnitudes were lower, particularly for BRCA2. The variation in risk by age at diagnosis of index case is consistent with the effects of other genes modifying cancer risk in carriers.
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| 4. |
- Antoniou, A C, et al.
(author)
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Breast and ovarian cancer risks to carriers of the BRCA1 5382insC and 185delAG and BRCA2 6174delT mutations: a combined analysis of 22 population based studies
- 2005
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In: Journal of Medical Genetics. - : BMJ. - 0022-2593 .- 1468-6244. ; 42:7, s. 602-603
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Journal article (peer-reviewed)abstract
- A recent report estimated the breast cancer risks in carriers of the three Ashkenazi founder mutations to be higher than previously published estimates derived from population based studies. In an attempt to confirm this, the breast and ovarian cancer risks associated with the three Ashkenazi founder mutations were estimated using families included in a previous meta-analysis of populatrion based studies. The estimated breast cancer risks for each of the founder BRCA1 and BRCA2 mutations were similar to the corresponding estimates based on all BRCA1 or BRCA2 mutations in the meta-analysis. These estimates appear to be consistent with the observed prevalence of the mutations in the Ashkenazi Jewish population.
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| 5. |
- Antoniou, A. C., et al.
(author)
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The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions
- 2008
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In: British Journal of Cancer. - : Springer Science and Business Media LLC. - 1532-1827 .- 0007-0920. ; 98:8, s. 1457-1466
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Journal article (peer-reviewed)abstract
- Multiple genetic loci confer susceptibility to breast and ovarian cancers. We have previously developed a model (BOADICEA) under which susceptibility to breast cancer is explained by mutations in BRCA1 and BRCA2, as well as by the joint multiplicative effects of many genes ( polygenic component). We have now updated BOADICEA using additional family data from two UK population-based studies of breast cancer and family data from BRCA1 and BRCA2 carriers identified by 22 population-based studies of breast or ovarian cancer. The combined data set includes 2785 families ( 301 BRCA1 positive and 236 BRCA2 positive). Incidences were smoothed using locally weighted regression techniques to avoid large variations between adjacent intervals. A birth cohort effect on the cancer risks was implemented, whereby each individual was assumed to develop cancer according to calendar period-specific incidences. The fitted model predicts that the average breast cancer risks in carriers increase in more recent birth cohorts. For example, the average cumulative breast cancer risk to age 70 years among BRCA1 carriers is 50% for women born in 1920 - 1929 and 58% among women born after 1950. The model was further extended to take into account the risks of male breast, prostate and pancreatic cancer, and to allow for the risk of multiple cancers. BOADICEA can be used to predict carrier probabilities and cancer risks to individuals with any family history, and has been implemented in userfriendly Web-based program(http://www.srl.cam.ac.uk/genepi/boadicea/boadicea_home. html).
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| 6. |
- Anwar, Mahwish, et al.
(author)
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A comparison of Unsupervised Learning Algorithms for Intrusion Detection in IEC 104 SCADA Protocol
- 2021
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In: Proceedings - International Conference on Machine Learning and Cybernetics. - : IEEE Computer Society. - 9781665466080
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Conference paper (peer-reviewed)abstract
- The power grid is a build-up of a mesh of thousands of sensors, embedded devices, and terminal units that communicate over different media. The heterogeneity of modern and legacy equipment calls for attention towards diverse network security measures. The critical infrastructure employs different security measures to detect and prevent adversaries, e.g., through signature-based tools. These approaches lack the potential to identify unknown attacks. Machine learning has the prospective to address novel attack vectors. This paper systematically evaluates the efficacy of learning algorithms from different families for intrusion detection in IEC 60870-5-104 protocol. One-class SVM and k-Nearest Neighbour unsupervised learning models show small potential when being tested on the IEC 104 unseen dataset with Area Under the Curve score 0.64 and 0.59, in the same order; and Matthews Correlation Coefficient value 0.3 and 0.2, respectively. The experimental results suggest little feasibility of the evaluated unsupervised learning approaches for anomaly detection in IEC 104 communication and recommend coupling it with other anomaly detection techniques. © 2021 IEEE.
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| 7. |
- Anwar, Mahwish, et al.
(author)
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Improving anomaly detection in SCADA network communication with attribute extension
- 2022
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In: Energy Informatics. - : Springer. - 2520-8942. ; 5:1
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Journal article (peer-reviewed)abstract
- Network anomaly detection for critical infrastructure supervisory control and data acquisition (SCADA) systems is the first line of defense against cyber-attacks. Often hybrid methods, such as machine learning with signature-based intrusion detection methods, are employed to improve the detection results. Here an attempt is made to enhance the support vector-based outlier detection method by leveraging behavioural attribute extension of the network nodes. The network nodes are modeled as graph vertices to construct related attributes that enhance network characterisation and potentially improve unsupervised anomaly detection ability for SCADA network. IEC 104 SCADA protocol communication data with good domain fidelity is utilised for empirical testing. The results demonstrate that the proposed approach achieves significant improvements over the baseline approach (average F1F1 score increased from 0.6 to 0.9, and Matthews correlation coefficient (MCC) from 0.3 to 0.8). The achieved outcome also surpasses the unsupervised scores of related literature. For critical networks, the identification of attacks is indispensable. The result shows an insignificant missed-alert rate (0.3%0.3% on average), the lowest among related works. The gathered results show that the proposed approach can expose rouge SCADA nodes reasonably and assist in further pruning the identified unusual instances.
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| 8. |
- Athle, Robin, et al.
(author)
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Effects of TiN Top Electrode Texturing on Ferroelectricity in Hf1-xZrxO2
- 2021
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In: ACS applied materials & interfaces. - : American Chemical Society (ACS). - 1944-8244 .- 1944-8252. ; 13:9, s. 11089-11095
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Journal article (peer-reviewed)abstract
- Ferroelectric memories based on hafnium oxide are an attractive alternative to conventional memory technologies due to their scalability and energy efficiency. However, there are still many open questions regarding the optimal material stack and processing conditions for reliable device performance. Here, we report on the impact of the sputtering process conditions of the commonly used TiN top electrode on the ferroelectric properties of Hf1-xZrxO2. By manipulating the deposition pressure and chemistry, we control the preferential orientation of the TiN grains between (111) and (002). We observe that (111) textured TiN is superior to (002) texturing for achieving high remanent polarization (Pr). Furthermore, we find that additional nitrogen supply during TiN deposition leads to >5× greater endurance, possibly by limiting the scavenging of oxygen from the Hf1-xZrxO2 film. These results help explain the large Pr variation reported in the literature for Hf1-xZrxO2/TiN and highlights the necessity of tuning the top electrode of the ferroelectric stack for successful device implementation.
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| 9. |
- Athle, Robin, et al.
(author)
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Improved Endurance of Ferroelectric HfxZr1–xO2 Integrated on InAs Using Millisecond Annealing
- 2022
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In: Advanced Materials Interfaces. - : Wiley. - 2196-7350. ; 9:27
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Journal article (peer-reviewed)abstract
- Ferroelectric HfxZr1–xO2 (HZO) is typically achieved by crystallization of an amorphous thin film via rapid thermal processing (RTP) at time scales of seconds to minutes. For integration on III–V semiconductors, this approach can severely degrade the sensitive HZO/III–V interface. To evaluate whether a reduced thermal budget can improve the interface quality, millisecond duration thermal anneals are utilized using a flash lamp annealer (FLA) on HZO/InAs capacitors. Through thorough electrical characterization such as polarization hysteresis, endurance, and capacitance-voltage measurements, as well as synchrotron-based chemical interface characterization, the FLA and RTP treatments are compared and the FLA results are found in lower interface defect density and higher endurance, but also have generally lower remanent polarization (Pr) compared to RTP. Additionally, ways to achieve high Pr and low interface defect density using multiple lower energy flashes, as well as by pre-crystallization during the ALD growth step are investigated. Using FLA, Pr exceeding 20 µC cm−2 is achieved, with extended endurance properties compared to RTP treatment and a considerably decreased defect density, indicative of a higher quality HZO/InAs interface. This work presents valuable insight into the successful integration of ferroelectric HZO on low thermal budget III–V semiconductors.
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| 10. |
- Athle, Robin, et al.
(author)
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Top Electrode Engineering for Freedom in Design and Implementation of Ferroelectric Tunnel Junctions Based on Hf1- xZrxO2
- 2022
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In: ACS Applied Electronic Materials. - : American Chemical Society (ACS). - 2637-6113. ; 4:3, s. 1002-1009
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Journal article (peer-reviewed)abstract
- Ferroelectric tunnel junctions (FTJs) based on ultrathin HfO2 have great potential as a fast and energy-efficient memory technology compatible with complementary metal oxide semiconductors. FTJs consist of a ferroelectric film sandwiched between two distinct electrodes, the properties of which are intricately linked to the electrical properties of the FTJs. Here we utilize a W crystallization electrode (CE) to achieve a high and reproducible remanent polarization, combined with a metal replacement process in which the W is carefully removed and replaced by another top electrode (TE). In this way we separate the ferroelectric film properties from the device design and can thereby evaluate the effect of the TE work function (WF) and conduction band electron density (ne) on the tunneling electroresistance (TER) and device reliability. We compare FTJs designed with a TiN bottom electrode and W, Cr, or Ni TE and find that the use of high electron density metals such as Ni or Cr as TE allows for an improved TER, albeit at the cost of reliability due to a large built-in electric field. To bypass this effect, a bilayer Cr/Ni TE is implemented, which allows for a high TER and minimal built-in field, leading to excellent retention and endurance beyond 108 cycles. The results presented here thus highlight a process flow for reliable design and implementation of FTJs.
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