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- Boström, Per, 1982-
(author)
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”Det här är ju dött tåg liksom…” : en studie av metaforer för ROMANTISK KÄRLEK i talad svenska
- 2018
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Doctoral thesis (other academic/artistic)abstract
- The purpose of this study is to investigate the metaphorization of ROMANTIC LOVE in spoken Swedish. The study is based on 4 semi-structured focus group conversations with participants in two age groups; 24–33 and 50–54. A Swedish short film and questions related to the film were used as stimuli for the conversations. Research questions asked are 1) How is the concept of ROMANTIC LOVE metaphorized in the recorded group conversations? 2) How does the metaphorization vary between the conversations? and 3) What cultural model for ROMANTIC LOVE in the conversations can be reconstructed based on identified metaphorizations? The study is situated within Cognitive Linguistics and the framework of Conceptual Metaphor Theory and a Discourse Dynamics Approach to Metaphor. Consequently, metaphor is seen as a cognitive, linguistic, socio-cultural and discursive phenomenon, where metaphorization is a dynamic process that develops, adapts and flows within the conversations and between the participants. Accordingly, the identified metaphorizations are considered to be influenced by the speakers and their embodied experiences, their embodied cognition, the discourse event, and socio-cultural aspects of metaphorization. The focus of the present study, ROMANTIC LOVE, is considered as a dynamic concept based on philosophical, feminist, psychological and metaphorical research. Metaphors are identified through a discourse dynamic version of MIP and MIPVU.From the analyses, 6 systematic metaphors are proposed, where ROMANTIC LOVE is metaphorized as a PHYSICAL OBJECT (incl. as a POSSESSION and as a LIVING ORGANISM), as a CONTAINER (incl. CONSTRUCTION and BODY as a CONTAINER), as TRAVELLING together (with primary focus on TRAVELLING together rather than SOURCE or TARGET), as a UNITY (with focus on how a UNITY is ESTABLISHED, MAINTAINED and DISSOLVED, ideally by two COMPATIBLE partners), as a PHYSICAL and NATURAL FORCE and as a DISEASE (where LOVE can affect a person’s perception and sanity). In addition, ROMANTIC LOVE is, in a small number of expressions, metaphorized as a CRIME, as a PHYSICAL CONFLICT and as a GAME. The variation in metaphorization is small between the conversations. Some metaphorizations seem to be related to the age of the participants. ROMANTIC LOVE ismoreover something people usually have influence over and in some ways can control. In total, 780 metaphorical expressions and 9 source domains are identified. Departing from the interplay betweenmetaphorization and culture, a cultural model for ROMANTIC LOVE is reconstructed, where a multifaceted, embodied and experiential concept of ROMANTIC LOVE emerges.
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| 2. |
- Boström, Pontus, 1982, et al.
(author)
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Hypoxia converts human macrophages into triglyceride-loaded foam cells.
- 2006
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In: Arteriosclerosis, thrombosis, and vascular biology. - 1524-4636. ; 26:8, s. 1871-6
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Journal article (peer-reviewed)abstract
- OBJECTIVE: Atherosclerotic lesions have regions that are hypoxic. Because the lesion contains macrophages that are loaded with lipid, we investigated whether hypoxia can influence the accumulation of lipids in these cells. METHODS AND RESULTS: Exposure of human macrophages to hypoxia for 24 hours resulted in an increased formation of cytosolic lipid droplets and an increased accumulation of triglycerides. Exposure of the macrophages to oxidized low-density lipoprotein (oxLDL) increased the accumulation of cytosolic lipid droplets because of an increase in cellular cholesterol esters. The accumulation of lipid droplets in oxLDL-treated cells was further increased after hypoxia, caused by an increased level of triglycerides. Expression analyses combined with immunoblot or RT-PCR demonstrated that hypoxia increased the expression of several genes that could promote the accumulation of lipid droplets. Hypoxia increased the mRNA and protein levels of adipocyte differentiation-related protein (ADRP). It is well known that an increased expression of ADRP increases the formation of lipid droplets. Hypoxia decreased the expression of enzymes involved in beta-oxidation (acyl-coenzyme A synthetase and acyl-coenzyme A dehydrogenase) and increased the expression of stearoyl-coenzyme A desaturase, an important enzyme in the fatty acid biosynthesis. Moreover, exposure to hypoxia decreased the rate of beta-oxidation, whereas the accumulation of triglycerides increased. CONCLUSIONS: The results demonstrate that exposure of human macrophages to hypoxia causes an accumulation of triglyceride-containing cytosolic lipid droplets. This indicates that the hypoxia present in atherosclerotic lesions can contribute to the formation of the lipid-loaded macrophages that characterize the lesion and to the accumulation of triglycerides in such lesions.
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| 5. |
- Boström, Pontus, 1982, et al.
(author)
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The SNARE protein SNAP23 and the SNARE-interacting protein Munc18c in human skeletal muscle are implicated in insulin resistance/type 2 diabetes.
- 2010
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In: Diabetes. - : American Diabetes Association. - 1939-327X .- 0012-1797. ; 59:8, s. 1870-8
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Journal article (peer-reviewed)abstract
- OBJECTIVE: Our previous studies suggest that the SNARE protein synaptosomal-associated protein of 23 kDa (SNAP23) is involved in the link between increased lipid levels and insulin resistance in cardiomyocytes. The objective was to determine whether SNAP23 may also be involved in the known association between lipid accumulation in skeletal muscle and insulin resistance/type 2 diabetes in humans, as well as to identify a potential regulator of SNAP23. RESEARCH DESIGN AND METHODS: We analyzed skeletal muscle biopsies from patients with type 2 diabetes and healthy, insulin-sensitive control subjects for expression (mRNA and protein) and intracellular localization (subcellular fractionation and immunohistochemistry) of SNAP23, and for expression of proteins known to interact with SNARE proteins. Insulin resistance was determined by a euglycemic hyperinsulinemic clamp. Potential mechanisms for regulation of SNAP23 were also investigated in the skeletal muscle cell line L6. RESULTS: We showed increased SNAP23 levels in skeletal muscle from patients with type 2 diabetes compared with that from lean control subjects. Moreover, SNAP23 was redistributed from the plasma membrane to the microsomal/cytosolic compartment in the patients with the type 2 diabetes. Expression of the SNARE-interacting protein Munc18c was higher in skeletal muscle from patients with type 2 diabetes. Studies in L6 cells showed that Munc18c promoted the expression of SNAP23. CONCLUSIONS: We have translated our previous in vitro results into humans by showing that there is a change in the distribution of SNAP23 to the interior of the cell in skeletal muscle from patients with type 2 diabetes. We also showed that Munc18c is a potential regulator of SNAP23.
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| 6. |
- Haikola, Simon, 1982-
(author)
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Bortom kontroll? : Den svenska kemikalieövervakningens logik
- 2012
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Doctoral thesis (other academic/artistic)abstract
- Kemikalier utgör en grundläggande beståndsdel av det senindustriella samhället, och en omfattande produktion av kemikalier brukar allmänt anses som en nödvändig förutsättning för teknisk utveckling och ekonomisk tillväxt. I Sverige ledde miljölarmen om DDT, PCB och kvicksilver på 1960- och 1970-talet till inrättandet av ett system för kemikaliekontroll som brukar framhållas som ett av världens främsta. Avhandlingen undersöker detta kontrollsystem och dess logik. Detta görs genom textanalys av propositioner, statliga utredningar, rapporter från Naturvårdsverket och Kemikalieinspektionen, samt genom intervjuer med anställda på sistnämnda myndigheter. Analysen identifierar kemikaliekontroll i Sverige som ett system genomsyrat av motsättningar, vilka bottnar i en epistemologisk paradox som innebär att ju mer kunskap som ackumuleras om kemikalier, desto mer ökar osäkerheten. Den konstanta ökningen av världens kemikalieproduktion, i kombination med kemikaliers epistemologiska komplexitet, placerar kontrollmyndigheterna i en omöjlig sits. Samtidigt visar avhandlingen att myndigheterna är delaktiga i att upprätthålla detta kontrollsystem som till stor del är ett system av simulerad kontroll. Dels förmedlar kontrollsystemet genom sin blotta existens intrycket av kontroll, och dels fungerar vissa centrala regulatoriska begrepp som signaler om kontroll, trots att de visar sig vara ihåliga. På så vis blir osäkerhet inom kontrollsystemet alltid ett undantag, trots att den är så utbredd.
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| 8. |
- Lindgren, Eva, et al.
(author)
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Skrivande för delaktighet och demokrati
- 2022. - 1
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In: Skrivdidaktik i grundskolan. - Lund : Studentlitteratur AB. - 9789144144931 ; , s. 43-67
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Book chapter (other academic/artistic)
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| 9. |
- Ström, Peter, 1984-, et al.
(author)
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Discourse of influence : participation and opinions in digital and print media
- 2024
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In: Sakprosa. - Oslo : Universitetet i Oslo. - 1502-6000 .- 1891-5108. ; 16:1, s. 1-34
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Journal article (peer-reviewed)abstract
- In democratic societies, exchange of written opinion is fundamental, but since the 1990s, public debate has gradually moved away from print media platforms to digital media platforms. In order to understand how a shift from print to digital media in opinion-oriented writing may have consequences for interaction and participation, it is relevant to investigate interpersonal aspects of opinion-oriented texts situated in digital and print media. The aim of the study is to explore and compare writers’ attitudes and the construction of the writer-reader-relationship in digital media (represented by Twitter) and (traditionally) print media (represented by letters to the editor, LEs). Bakhtinian dialogism and appraisal theory form the theoretical backdrop of the study. Results show that in the LEs, writers tend to take a negative general value position, but in the tweets, the writers’ attitude is more often either positive or negative, making Twitter a more diverse platform. Furthermore, attitudinal meaning is more transparent in the LEs, indicating that tweets are more often specialized, and readers who are not familiar with the context and interactional style of specific writers may be excluded from the communication. Another result is that a shift from print to digital media platforms seems to turn the focus of discussion more towards attitudes and perspectives in general, and less towards writers’ own attitudes. Therefore, digital media opinion exchange can be understood as a meta-discussion of attitudes, while print media rather transmit writers’ personal attitudes.
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