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1.	Bosma, M, et al. (author) FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice 2016 In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7, s. 11314- Journal article (peer-reviewed)abstract FNDC4 is a secreted factor sharing high homology with the exercise-associated myokine irisin (FNDC5). Here we report that Fndc4 is robustly upregulated in several mouse models of inflammation as well as in human inflammatory conditions. Specifically, FNDC4 levels are increased locally at inflamed sites of the intestine of inflammatory bowel disease patients. Interestingly, administration of recombinant FNDC4 in the mouse model of induced colitis markedly reduces disease severity compared with mice injected with a control protein. Conversely, mice lacking Fndc4 develop more severe colitis. Analysis of binding of FNDC4 to different immune cell types reveals strong and specific binding to macrophages and monocytes. FNDC4 treatment of bone marrow-derived macrophages in vitro results in reduced phagocytosis, increased cell survival and reduced proinflammatory chemokine expression. Hence, treatment with FNDC4 results in a state of dampened macrophage activity, while enhancing their survival. Thus, we have characterized FNDC4 as a factor with direct therapeutic potential in inflammatory bowel disease and possibly other inflammatory diseases.
2.	Bostrom, P, et al. (author) Is irisin a human exercise gene? Reply 2012 In: NATURE. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 488:7413, s. E10-E11 Journal article (other academic/artistic)
3.	Bloch, S, et al. (author) Immune response profiling of primary monocytes and oral keratinocytes to different Tannerella forsythia strains and their cell surface mutants 2018 In: Molecular oral microbiology. - : Wiley. - 2041-1014 .- 2041-1006. ; 33:2, s. 155-167 Journal article (peer-reviewed)
4.	Clark, R, et al. (author) Colony-stimulating factor-1 receptor blockade attenuates inflammation in inflamed gingival tissue explants 2021 In: Journal of periodontal research. - : Wiley. - 1600-0765 .- 0022-3484. ; 56:6, s. 1141-1153 Journal article (peer-reviewed)
5.	Clark, R, et al. (author) Expression of colony-stimulating factor 1 and interleukin-34 in gingival tissue and gingival fibroblasts from periodontitis patients and controls 2020 In: Journal of periodontology. - 1943-3670. ; 91:6, s. 828-835 Journal article (peer-reviewed)
6.	de Mello-Neto, JM, et al. (author) Peri-implant treatment reduces the salivary levels of Colony stimulator factor-1 and S100A8/A9 2021 In: Odontology. - : Springer Science and Business Media LLC. - 1618-1255 .- 1618-1247. ; 109:2, s. 540-546 Journal article (peer-reviewed)
7.	Figueredo, CM, et al. (author) Presence of anti-Porphyromonas gingivalis-peptidylarginine deiminase antibodies in serum from juvenile systemic lupus erythematosus patients 2018 In: Acta reumatologica portuguesa. - 2184-8777. ; 43:3, s. 239-240 Journal article (other academic/artistic)
8.	Lira-Junior, R, et al. (author) Levels of myeloid-related proteins in saliva for screening and monitoring of periodontal disease 2021 In: Journal of clinical periodontology. - : Wiley. - 1600-051X .- 0303-6979. ; 48:11, s. 1430-1440 Journal article (peer-reviewed)
9.	Lira-Junior, R, et al. (author) Oral-gut connection: one step closer to an integrated view of the gastrointestinal tract? 2018 In: Mucosal immunology. - : Elsevier BV. - 1935-3456 .- 1933-0219. ; 11:2, s. 316-318 Journal article (peer-reviewed)
10.	Lira-Junior, R, et al. (author) Salivary and Serum Markers Related to Innate Immunity in Generalized Aggressive Periodontitis 2017 In: Journal of periodontology. - : Wiley. - 1943-3670 .- 0022-3492. ; 88:12, s. 1339-1347 Journal article (peer-reviewed)

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Type of publication: journal article (22)

Type of content: peer-reviewed (19); other academic/artistic (3)

Author/Editor: Bostrom, EA (22); Almer, S (7); Zwicker, S (5); Majster, M. (4); Bostanci, N (3); Clark, R (3); show more...; Bosma, M (3); Johannsen, G (2); Gerling, M (2); Sztajnbok, FR (2); Soderman, J (2); Lange, S. (1); Johannsen, A (1); Wu, J (1); Hoog, C (1); Buhlin, K (1); Ozturk, VO (1); Emingil, G (1); Toftgard, R (1); Eriksson, A (1); Bjurshammar, N (1); Yucel-Lindberg, T (1); Belibasakis, GN (1); Gustafsson, A (1); Kats, A (1); Shilkova, O (1); Ye, L (1); Iwata, Y. (1); Sugars, RV (1); Cinti, S (1); Hojlund, K. (1); Bloch, S (1); Schaffer, C (1); Sjoling, A (1); Wermeling, F (1); Pasto, J (1); Georgiadi, A (1); Graham, E (1); Bostrom, PA (1); Bostrom, P. (1); Jedrychowski, MP (1); Korde, A (1); Lo, JC (1); Rasbach, KA (1); Choi, JH (1); Long, JZ (1); Kajimura, S (1); Zingaretti, MC (1); Vind, BF (1); Tu, H (1); show less...

University: Karolinska Institutet (22)

Language: English (22)

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