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Träfflista för sökning "WFRF:(Bostrom PA) "

Search: WFRF:(Bostrom PA)

  • Result 1-8 of 8
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1.
  • Bosma, M, et al. (author)
  • FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice
  • 2016
  • In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7, s. 11314-
  • Journal article (peer-reviewed)abstract
    • FNDC4 is a secreted factor sharing high homology with the exercise-associated myokine irisin (FNDC5). Here we report that Fndc4 is robustly upregulated in several mouse models of inflammation as well as in human inflammatory conditions. Specifically, FNDC4 levels are increased locally at inflamed sites of the intestine of inflammatory bowel disease patients. Interestingly, administration of recombinant FNDC4 in the mouse model of induced colitis markedly reduces disease severity compared with mice injected with a control protein. Conversely, mice lacking Fndc4 develop more severe colitis. Analysis of binding of FNDC4 to different immune cell types reveals strong and specific binding to macrophages and monocytes. FNDC4 treatment of bone marrow-derived macrophages in vitro results in reduced phagocytosis, increased cell survival and reduced proinflammatory chemokine expression. Hence, treatment with FNDC4 results in a state of dampened macrophage activity, while enhancing their survival. Thus, we have characterized FNDC4 as a factor with direct therapeutic potential in inflammatory bowel disease and possibly other inflammatory diseases.
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2.
  • Bostrom, PA (author)
  • All organ exercise for metabolic health
  • 2014
  • In: Drug discovery today. - : Elsevier BV. - 1878-5832 .- 1359-6446. ; 19:7, s. 997-998
  • Journal article (other academic/artistic)
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  • Gustafsson, G, et al. (author)
  • The electric field and wave experiment for the Cluster mission
  • 1997
  • In: SPACE SCIENCE REVIEWS. - : KLUWER ACADEMIC PUBL. - 0038-6308. ; 79:1-2, s. 137-156
  • Journal article (peer-reviewed)abstract
    • The electric-field and wave experiment (EFW) on Cluster is designed to measure the electric-field and density fluctuations with sampling rates up to 36 000 samples s(-1). Langmuir probe sweeps can also be made to determine the electron density and tempera
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  • Result 1-8 of 8

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