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1.	Ahlen, G, et al. (author) Containing "The Great Houdini" of viruses: combining direct acting antivirals with the host immune response for the treatment of chronic hepatitis C 2013 In: Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy. - : Elsevier BV. - 1532-2084. ; 16:3-5, s. 60-67 Journal article (peer-reviewed)
2.	Bansal, R, et al. (author) HEPATITIS C NONSTRUCTURAL PROTEIN 3/4A DAMPENS INFLAMMATION AND CONTRIBUTES TO SLOW FIBROSIS PROGRESSION DURING CHRONIC LIVER INJURY IN MICE 2014 In: JOURNAL OF HEPATOLOGY. - 0168-8278. ; 60:1, s. S138-S138 Conference paper (other academic/artistic)
3.	Bansal, R, et al. (author) Hepatitis C Virus Nonstructural 3/4A Protein Dampens Inflammation and Contributes to Slow Fibrosis Progression during Chronic Fibrosis In Vivo 2015 In: PloS one. - : Public Library of Science (PLoS). - 1932-6203. ; 10:6, s. e0128466- Journal article (peer-reviewed)
4.	Bode, JG, et al. (author) Hepatitis C virus (HCV) employs multiple strategies to subvert the host innate antiviral response 2008 In: Biological chemistry. - 1431-6730. ; 389:10, s. 1283-1298 Journal article (peer-reviewed)
5.	Bode, JG, et al. (author) Interplay between host cell and hepatitis C virus in regulating viral replication 2009 In: Biological chemistry. - 1437-4315. ; 390:10, s. 1013-1032 Journal article (peer-reviewed)
6.	Brass, A, et al. (author) The role of chemokines in hepatitis C virus-mediated liver disease 2014 In: International journal of molecular sciences. - : MDPI AG. - 1422-0067. ; 15:3, s. 4747-4779 Journal article (peer-reviewed)
7.	Brenndorfer, ED, et al. (author) ANALYSIS OF HCV MARKERS AND IMMUNE RESPONSES 5-20 YEARS AFTER SUCCESSFUL HCV THERAPY SUGGESTS THAT MOST PATIENTS ARE CURED 2014 In: JOURNAL OF HEPATOLOGY. - 0168-8278. ; 60:1, s. S325-S325 Conference paper (other academic/artistic)
8.	Brenndorfer, ED, et al. (author) Anti-tumor necrosis factor α treatment promotes apoptosis and prevents liver regeneration in a transgenic mouse model of chronic hepatitis C 2010 In: Hepatology (Baltimore, Md.). - : Ovid Technologies (Wolters Kluwer Health). - 1527-3350 .- 0270-9139. ; 52:5, s. 1553-1563 Journal article (peer-reviewed)
9.	Brenndorfer, ED, et al. (author) Cleavage of the T cell protein tyrosine phosphatase by the hepatitis C virus nonstructural 3/4A protease induces a Th1 to Th2 shift reversible by ribavirin therapy 2014 In: Journal of immunology (Baltimore, Md. : 1950). - : The American Association of Immunologists. - 1550-6606 .- 0022-1767. ; 192:4, s. 1671-1680 Journal article (peer-reviewed)abstract Ribavirin has proven to be a key component of hepatitis C therapies both involving IFNs and new direct-acting antivirals. The hepatitis C virus–mediated interference with intrahepatic immunity by cleavage of mitochondrial antiviral signaling protein (MAVS) and T cell protein tyrosine phosphatase (TCPTP) suggests an avenue for compounds that may counteract these effects. We therefore studied the effects of ribavirin, with or without inhibition of the nonstructural (NS)3/4A protease, on intrahepatic immunity. The intrahepatic immunity of wild-type and NS3/4A-transgenic mice was determined by Western blot, ELISA, flow cytometry, and survival analysis. Various MAVS or TCPTP constructs were injected hydrodynamically to study their relevance. Ribavirin pretreatment was performed in mice expressing a functional or inhibited NS3/4A protease to analyze its effect on NS3/4A-mediated changes. Intrahepatic NS3/4A expression made mice resistant to TNF-α–induced liver damage and caused an alteration of the intrahepatic cytokine (IFN-γ and IL-10) and chemokine (CCL3, CCL17, CCL22, CXCL9, and CXCL11) profiles toward an anti-inflammatory state. Consistent with this, the number of intrahepatic Th1 cells and IFN-γ+ T cells in NS3/4A-transgenic mice decreased, whereas the amount of Th2 cells increased. These effects could be reversed by injection of uncleavable TCPTP but not uncleavable MAVS and were absent in a mouse expressing a nonfunctional NS3/4A protease. Importantly, the NS3/4A-mediated effects were reversed by ribavirin treatment. Thus, cleavage of TCPTP by NS3/4A induces a shift of the intrahepatic immune response toward a nonantiviral Th2-dominated immunity. These effects are reversed by ribavirin, supporting that ribavirin complements the effects of direct-acting antivirals as an immunomodulatory compound.
10.	Brenndorfer, ED, et al. (author) HCV NS3/4A INTERFERES WITH INTRAHEPATIC IMMUNITY AND TNFA-INDUCED LIVER DAMAGE BY MODULATING CCL17 AND CXCL9 SECRETION IN VIVO 2010 In: JOURNAL OF HEPATOLOGY. - 0168-8278. ; 52, s. S265-S265 Conference paper (other academic/artistic)

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Type of publication: journal article (14); conference paper (8)

Type of content: peer-reviewed (14); other academic/artistic (8)

Author/Editor: Brenndorfer, ED (22); Sallberg, M (17); Frelin, L (13); Bode, JG (9); Ahlen, G (8); Brass, A (7); show more...; Chen, M (3); Soderholm, J (3); Weiland, M (3); Haussinger, D (3); Karthe, J (3); Chen, A. (2); Weiland, O (2); Derk, E (2); Aleman, S (2); Milich, DR (2); Bansal, R (2); Prakash, J (2); Storm, G (2); Glaumann, H (2); Liu, J. (1); Zhao, Y. (1); aut (1); Hassan, M (1); Johansson, M (1); Fischler, B (1); Hultcrantz, R (1); Holmqvist, B. (1); Holmstrom, F (1); Rahbin, N (1); Hultgren, C (1); Alheim, M (1); Axén, N. (1); Rozell, B (1); Einberg, AP (1); Hallberg, L (1); Bartenschlager, R (1); Erhardt, A (1); Eilard, A (1); Frydén, A (1); Hedenstierna, M (1); Bankwitz, D (1); Behrendt, P (1); Uhnoo, I (1); Norkrans, G (1); Cardell, K (1); Pietschmann, T (1); Jiao, JA (1); Freblin, L (1); Cebula, P (1); show less...

University: Karolinska Institutet (22)

Language: English (22)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

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