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- Niesmann, Katharina, et al.
(author)
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Dendritic spine formation and synaptic function require neurobeachin
- 2011
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 2, s. 557-
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Journal article (peer-reviewed)abstract
- A challenge in neuroscience is to understand the mechanisms underlying synapse formation. Most excitatory synapses in the brain are built on spines, which are actin-rich protrusions from dendrites. Spines are a major substrate of brain plasticity, and spine pathologies are observed in various mental illnesses. Here we investigate the role of neurobeachin (Nbea), a multidomain protein previously linked to cases of autism, in synaptogenesis. We show that deletion of Nbea leads to reduced numbers of spinous synapses in cultured neurons from complete knockouts and in cortical tissue from heterozygous mice, accompanied by altered miniature postsynaptic currents. In addition, excitatory synapses terminate mostly at dendritic shafts instead of spine heads in Nbea mutants, and actin becomes less enriched synaptically. As actin and synaptopodin, a spine-associated protein with actin-bundling activity, accumulate ectopically near the Golgi apparatus of mutant neurons, a role emerges for Nbea in trafficking important cargo to pre- and postsynaptic compartments.
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- O'Seaghdha, Conall M., et al.
(author)
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Meta-Analysis of Genome-Wide Association Studies Identifies Six New Loci for Serum Calcium Concentrations
- 2013
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In: PLOS Genetics. - : Public Library of Science (PLoS). - 1553-7390 .- 1553-7404. ; 9:9, s. e1003796-
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Journal article (peer-reviewed)abstract
- Calcium is vital to the normal functioning of multiple organ systems and its serum concentration is tightly regulated. Apart from CASR, the genes associated with serum calcium are largely unknown. We conducted a genome-wide association meta-analysis of 39,400 individuals from 17 population-based cohorts and investigated the 14 most strongly associated loci in <= 21,679 additional individuals. Seven loci (six new regions) in association with serum calcium were identified and replicated. Rs1570669 near CYP24A1 (P = 9.1E-12), rs10491003 upstream of GATA3 (P = 4.8E-09) and rs7481584 in CARS (P = 1.2E-10) implicate regions involved in Mendelian calcemic disorders: Rs1550532 in DGKD (P = 8.2E-11), also associated with bone density, and rs7336933 near DGKH/KIAA0564 (P = 9.1E-10) are near genes that encode distinct isoforms of diacylglycerol kinase. Rs780094 is in GCKR. We characterized the expression of these genes in gut, kidney, and bone, and demonstrate modulation of gene expression in bone in response to dietary calcium in mice. Our results shed new light on the genetics of calcium homeostasis.
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- Wong, Grace Y., et al.
(author)
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Social forestry in Southeast Asia : Evolving interests, discourses and the many notions of equity
- 2020
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In: Geoforum. - : Elsevier BV. - 0016-7185 .- 1872-9398. ; 117, s. 246-258
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Journal article (peer-reviewed)abstract
- Southeast Asia has long promoted social forestry (SF) in conservation areas, fallow forests, tree plantations, areas in timber concessions and locally managed agro-forest systems, with the engagement of diverse actors and objectives. SF has evolved from early aims of empowerment and devolution of rights advocated by global reform movements, and is now reframed in the market ideal as a win–win–win endeavor for sustainable forest management, climate change mitigation and robust entrepreneurial livelihoods. Southeast Asian states have formulated numerous standardized SF programs and policies that are often linked to broader development goals and priorities, but which have not always been a ‘win’ for local communities in falling short to provide full tenure rights. Civil society organizations that have provided grounded perspectives on environmental justice and rights have also converged with states on entrepreneurship and market-based solutions. Meanwhile, the private sector actor that is seen as key to these solutions is conspicuously absent within the SF policy space. Within this space of diverse and at times contradictory objectives, whose interests do SF policies serve? We examine the social forestry assemblage to investigate the different discourses, interests and agendas in the implementation of SF schemes in Indonesia, Vietnam, and the Malaysian state of Sabah. The formal SF schemes involve shifting or reinforcing old discourses around forest problems and possible solutions, territorialization processes that can lead to inequities in the exclusion of rights, participation and access, and risks exacerbating contestations and inequities in claims to forest land and resources.
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