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1.	Eichhorst, B., et al. (author) First-Line Venetoclax Combinations in Chronic Lymphocytic Leukemia. 2023 In: New England Journal of Medicine. - : MASSACHUSETTS MEDICAL SOC. - 0028-4793 .- 1533-4406. ; 388:19, s. 1739-1754 Journal article (peer-reviewed)abstract Background Randomized trials of venetoclax plus anti-CD20 antibodies as first-line treatment in fit patients (i.e., those with a low burden of coexisting conditions) with advanced chronic lymphocytic leukemia (CLL) have been lacking. Methods In a phase 3, open-label trial, we randomly assigned, in a 1:1:1:1 ratio, fit patients with CLL who did not have TP53 aberrations to receive six cycles of chemoimmunotherapy (fludarabine-cyclophosphamide-rituximab or bendamustine-rituximab) or 12 cycles of venetoclax-rituximab, venetoclax-obinutuzumab, or venetoclax-obinutuzumab-ibrutinib. Ibrutinib was discontinued after two consecutive measurements of undetectable minimal residual disease or could be extended. The primary end points were undetectable minimal residual disease (sensitivity,

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Type of publication: journal article (1)

Type of content: peer-reviewed (1)

Author/Editor: Juliusson, Gunnar (1); Baumann, Michael (1); Geisler, Christian (1); Eichhorst, B (1); Frederiksen, Henrik (1); Hallek, M. (1); show more...; Kater, Arnon P. (1); Niemann, Carsten U. (1); Stilgenbauer, Stepha ... (1); Da Cunha-Bang, Caspa ... (1); Bahlo, Jasmin (1); Zhang, Can (1); Christiansen, Ilse (1); Noesslinger, Thomas (1); Janssens, Ann (1); Fuerstenau, Moritz (1); von Tresckow, Julia (1); Robrecht, Sandra (1); Gregor, Michael (1); Thornton, Patrick (1); Staber, Philipp B. (1); Tadmor, Tamar (1); Lindstrom, Vesa (1); Schneider, Christof (1); Poulsen, Christian B ... (1); Illmer, Thomas (1); Schoettker, Bjoern (1); van der Klift, Marjo ... (1); Jaeger, Ulrich (1); Leys, Maria B. L. (1); Hoogendoorn, Mels (1); Lotfi, Kourosh (1); Hebart, Holger (1); Gaska, Tobias (1); Koene, Harry (1); Enggaard, Lisbeth (1); Goede, Jereon (1); Regelink, Josien C. (1); Widmer, Anouk (1); Simon, Florian (1); De Silva, Nisha (1); Fink, Anna-Maria (1); Fischer, Kirsten (1); Wendtner, Clemens-Ma ... (1); Kreuzer, Karl A. (1); Ritgen, Matthias (1); Brueggemann, Monika (1); Tausch, Eugen (1); Levin, Mark-David (1); van Oers, Marinus (1); show less...

University: Linköping University (1); Lund University (1)

Language: English (1)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

Year: 2023 (1)

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