SwePub
Sök i SwePub databas

  Extended search

Träfflista för sökning "WFRF:(Bruns Tom) "

Search: WFRF:(Bruns Tom)

  • Result 1-2 of 2
Sort/group result
   
EnumerationReferenceCoverFind
1.
  • Nilsson, Magnus, et al. (author)
  • Neoadjuvant Chemoradiotherapy and Surgery for Esophageal Squamous Cell Carcinoma Versus Definitive Chemoradiotherapy With Salvage Surgery as Needed : The Study Protocol for the Randomized Controlled NEEDS Trial
  • 2022
  • In: Frontiers in Oncology. - : Frontiers Media S.A.. - 2234-943X. ; 12
  • Journal article (peer-reviewed)abstract
    • Background: The globally dominant treatment with curative intent for locally advanced esophageal squamous cell carcinoma (ESCC) is neoadjuvant chemoradiotherapy (nCRT) with subsequent esophagectomy. This multimodal treatment leads to around 60% overall 5-year survival, yet with impaired post-surgical quality of life. Observational studies indicate that curatively intended chemoradiotherapy, so-called definitive chemoradiotherapy (dCRT) followed by surveillance of the primary tumor site and regional lymph node stations and surgery only when needed to ensure local tumor control, may lead to similar survival as nCRT with surgery, but with considerably less impairment of quality of life. This trial aims to demonstrate that dCRT, with selectively performed salvage esophagectomy only when needed to achieve locoregional tumor control, is non-inferior regarding overall survival, and superior regarding health-related quality of life (HRQOL), compared to nCRT followed by mandatory surgery, in patients with operable, locally advanced ESCC.Methods: This is a pragmatic open-label, randomized controlled phase III, multicenter trial with non-inferiority design with regard to the primary endpoint overall survival and a superiority hypothesis for the experimental intervention dCRT with regard to the main secondary endpoint global HRQOL one year after randomization. The control intervention is nCRT followed by preplanned surgery and the experimental intervention is dCRT followed by surveillance and salvage esophagectomy only when needed to secure local tumor control. A target sample size of 1200 randomized patients is planned in order to reach 462 events (deaths) during follow-up.
  •  
2.
  •  
Skapa referenser, mejla, bekava och länka
  • Result 1-2 of 2
Type of publication
journal article (2)
Type of content
peer-reviewed (2)
Author/Editor
Nilsson, Magnus (1)
Abarenkov, Kessy (1)
Kõljalg, Urmas (1)
Nilsson, R. Henrik, ... (1)
Larsson, Karl-Henrik ... (1)
Lindahl, Björn (1)
show more...
Tedersoo, Leho (1)
Kjöller, Rasmus (1)
Johansson, Jan (1)
Stenlid, Jan (1)
Johansson, Hemming (1)
Edholm, David (1)
Alexandersson von Dö ... (1)
Quince, Christopher (1)
Lagergren, Pernilla (1)
Wallner, Bengt, 1962 ... (1)
Hedberg, Jakob, 1972 ... (1)
Hellström, Mats (1)
Piessen, Guillaume (1)
Reynolds, John V. (1)
de Manzoni, Giovanni (1)
Barbour, Andrew (1)
Gagliardi, Giovanna (1)
Kauserud, Håvard (1)
Li, Yin (1)
Szabo, Eva (1)
Ferri, Lorenzo (1)
Rosati, Riccardo (1)
olafsdottir, Halla (1)
Klevebro, Fredrik (1)
van Hillegersberg, R ... (1)
Joshi, Amit (1)
Aahlin, Eirik Kjus (1)
Lordick, Florian (1)
Crosby, Tom (1)
Markar, Sheraz (1)
Bruns, Christiane (1)
Carlsen, Tor (1)
Pennanen, Taina (1)
Gebski, Val (1)
Pramesh, C. S. (1)
Villegas, Fernanda (1)
Wang, Qiao-Li (1)
Smyth, Elizabeth (1)
Al-Haidari, Ghazwan (1)
Rekstad, Lars Cato (1)
Mummudi, Naveen (1)
Wong, Rebecca K.S. (1)
O’Callaghan, Chris (1)
Lukovic, Jelena (1)
show less...
University
University of Gothenburg (1)
Umeå University (1)
Uppsala University (1)
Linköping University (1)
Karolinska Institutet (1)
Swedish University of Agricultural Sciences (1)
Language
English (2)
Research subject (UKÄ/SCB)
Natural sciences (1)
Medical and Health Sciences (1)
Agricultural Sciences (1)

Year

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view