| 1. |
- Bougas, Kostas, et al.
(author)
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Bone apposition to laminin-1 coated implants : Histologic and 3D evaluation
- 2013
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In: International Journal of Oral and Maxillofacial Surgery. - : Elsevier BV. - 0901-5027 .- 1399-0020. ; 42:5, s. 677-682
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Journal article (peer-reviewed)abstract
- Laminin-1 has been reported as one of the factors responsible for the nucleation of calcium phosphates and, in vitro, has been reported to selectively recruit osteoprogenitors. This article focused on its in vivo effects, and evaluated the effect of laminin-1 local application on osseointegration. Polished cylindrical hydroxyapatite implants were coated with laminin-1 (test) and the bone responses in the rabbit tibiae after 2 and 4 weeks were evaluated and compared to the non-coated implants (control). Before the samples were processed for histological sectioning, they were three-dimensionally analysed with micro computed tomography (μCT). Both evaluation methods were analysed with regards to bone area around the implant and bone to implant contact. From the histologic observation, new bone formation around the laminin-1 coated implant at 2 weeks seemed to have increased the amount of supporting bone around the implant, however, at 4 weeks, the two groups presented no notable differences. The two-dimensional and three-dimensional morphometric evaluation revealed that both histologic and three-dimensional analysis showed some tendency in favour of the test group implants, however there was no statistical significance between the test and control group results.
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| 2. |
- De Wilde, Elisabeth A. W. J., et al.
(author)
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The soft tissue immunologic response to hydroxyapatite-coated transmucosal implant surfaces : a study in humans
- 2015
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In: Clinical Implant Dentistry and Related Research. - : John Wiley & Sons. - 1523-0899 .- 1708-8208. ; 17:S1, s. e65-e74
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Journal article (peer-reviewed)abstract
- ObjectiveTo evaluate the soft tissue response in humans immunologically and histologically after placement of mini-implants coated with or without nano-size hydroxyapatite coatings. Material and MethodsCommercially pure (cp) titanium mini-implants (n=13) or nano-hydroxyapatite-coated ones (n=12) were randomly placed into partially edentulous jaws. Crevicular fluid was sampled 1week after placement and subjected to quantitative polymerase chain reaction analysis to explore the inflammatory markers. After 8weeks, implants and surrounding soft and hard tissue were trephined, and undecalcified ground sections were prepared. Inflammatory cell accumulation within a defined region of interest in the soft tissue was quantified histomorphometrically. ResultsNo statistically significant differences in immunological response to the different implant surfaces were found for IL-6 (p=.438), TGF-2 (p=.467), MMP-8 (p=.758), CCL-3 (p=.758), IL-8 (p=.771), and IL-1 (0.771). Histomorphometric evaluation presented no statistically significant difference between the two mini-implant surfaces with regards to number of inflammatory cells (p=.669). ConclusionNano-hydroxyapatite-coated surfaces in the transmucosal region yielded similar inflammatory response and is suggested to be as biocompatible as commercially pure titanium surfaces.
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| 3. |
- Galli, Silvia, et al.
(author)
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Surface Characterization and Clinical Review of Two Commercially Available Implants
- 2013
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In: Implant dentistry. - : Lamy, Wolters Kluwer. - 1538-2982 .- 1056-6163. ; 22:5, s. 507-518
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Journal article (peer-reviewed)abstract
- Purpose:To characterize topographically and chemically the surfaces of 2 commercially available implants. Furthermore, to gather an overview of the clinical results of these implant systems.Materials and Methods:Two commercially available oral implants were analyzed using optical interferometry, scanning electron microscopy, and energy dispersive spectroscopy. In addition, a literature search for all the clinical articles on the same implants was performed.Results:No significant differences of topographical parameters were found between the 2 implants, except for the hybrid parameter Sdr presenting significant higher values for the Ankylos implants. Both surfaces had a homogenous microporosity. At higher magnifications of scanning electron microscope images, evenly distributed nanostructures (approximately 10 nm) were visible. Chemically, mainly titanium, oxygen and carbon were detected. Fifty-six clinical articles were included for the review. The implant survival rates (minimum follow-up: 5 years) ranged between 87.7% and 100%.Conclusions:The examined commercially available implants showed a moderately rough surface, with a homogenous microporosity. Nanofeatures were detected on the surface of both implants. The clinical performances of these implants were comparable to that of other commercialized implant systems.
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| 4. |
- Johansson, Lars-Åke, 1950, et al.
(author)
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Evaluation of bone regeneration after three different lateral sinus elevation procedures using micro-computed tomography of retrieved experimental implants and surrounding bone: a clinical, prospective, and randomized study.
- 2013
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In: The International journal of oral & maxillofacial implants. - : Quintessence Publishing. - 1942-4434 .- 0882-2786. ; 28:2, s. 579-86
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Journal article (peer-reviewed)abstract
- To compare three different lateral sinus elevation procedures concerning new bone formation by using micro–computed tomography (micro-CT) of retrieved implants. Materials and Methods: Twenty-four consecutive partially dentate patients with a mean age of 64 years were included in the study and provided with 30 sinus elevation procedures. Three procedures for lateral sinus elevation were used: lateral sinus elevation with replacement of bone window and without bone graft (BW), lateral sinus elevation and covering osteotomy site with a collagen membrane and without bone graft (CM), and lateral sinus elevation with autogenous bone graft (ABG). Experimental implants were retrieved after 7 months of healing and analyzed by micro-CT. Results: One implant was found not to be integrated at the time of implant retrieval. This implant belonged to group CM and was excluded when calculating bone-to-implant contact (BIC) and intrasinus bone levels. The integrity of the lateral sinus bony wall was determined at the time of implant removal. In group ABG, all lateral sinus walls were ossified. In group BW, one lateral sinus wall was not completely ossified and in group CM, two lateral sinus walls. There were no statistical differences in %BIC between the groups: 93.5% (BW), 92.0% (CM) and 93.5% (ABG). Additionally, no statistical differences were found in apical intrasinus bone levels between the groups. When surfaces were compared within the same implant, a statistical difference was found between the apicobuccal distance and the apicolingual distance. The mean apicobuccal distances/apicolingual distances were 0.6 mm/1.2 mm for the BW group, 0.5 mm/0.8 mm for the CM group, and 0.6 mm/0.8 mm for the ABG group (P = .003). Conclusions: All three procedures were statistically equal when new bone formation was compared. Most of the examined implants’ apices were not covered with bone at the time of retrieval.
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| 5. |
- Naito, Yoshihito, et al.
(author)
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The influence of 1α.25-dihydroxyvitamin d3 coating on implant osseointegration in the rabbit tibia
- 2014
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In: Journal of Oral & Maxillofacial Research. - : STILUS OPTIMUS. - 2029-283X. ; 5:3
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Journal article (peer-reviewed)abstract
- OBJECTIVES: This study aims to evaluate bone response to an implant surface modified by 1α,25-dihydroxyvitamin D3 [1.25-(OH)2D3] in vivo and the potential link between 1.25-(OH) 2D3 surface concentration and bone response. MATERIAL AND METHODS: Twenty-eight implants were divided into 4 groups (1 uncoated control, 3 groups coated with 1.25-(OH)2D3 in concentrations of 10(-8), 10(-7) and 10(-6) M respectively), placed in the rabbit tibia for 6 weeks. Topographical analyses were carried out on coated and uncoated discs using interferometer and atomic-force-microscope (AFM). Twenty-eight implants were histologically observed (bone-to-implant-contact [BIC] and new-bone-area [NBA]). RESULTS: The results showed that the 1.25-(OH)2D3 coated implants presented a tendency to osseointegrate better than the non-coated surfaces, the differences were not significant (P > 0.05). CONCLUSIONS: The effect of 1.25-(OH)2D3 coating to implants suggested possible dose dependent effects, however no statistical differences could be found. It is thought that the base substrate topography (turned) could not sustain sufficient amount of 1.25-(OH)2D3 enough to present significant biologic responses. Thus, development a base substrate that can sustain 1.25-(OH)2D3 for a long period is necessary in future studies.
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| 6. |
- Roman-Torres, Caio Vinicius G, et al.
(author)
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Comparison Of Full-Mouth Scaling and Quadrant-Wise Scaling in the Treatment of Adult Chronic Periodontitis
- 2018
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In: Brazilian Dental Journal. - : Associacao Brasileira De Divulgacao Cientifica. - 0103-6440 .- 1806-4760. ; 29:3, s. 296-300
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Journal article (peer-reviewed)abstract
- In the search for the ideal treatment of periodontal disease various non-surgical techniques should be considered. The objective of this study was to evaluate the efficacy of full-mouth scaling (FMS) by clinical and microbiological parameters. 670 individuals were evaluated with 230 subjects meeting the selection criteria and were divided into two groups; 115 subjects treated with FMS and 115 treated with weekly sessions of scaling and root planning (SRP). The patient population had a mean age of 51.67 years, with moderate chronic periodontitis. Subjects were evaluated prior to treatment (T1) and 90 days after execution of therapy (T2), with regards to: probing depth (PD), clinical attachment level (CAL), plaque index (PI), gingival index (GI), and microbial detection for the presence of Porphyromonas gingivalis (P.g.) and Prevotella intermedia (P.i.) by culture method and confirmed by biochemical tests. Subjects treated in the FMS group also rinsed with 0.12% chlorhexidine mouthwash for seven days following treatment. The results were analyzed using statistical Student's t-test and chi-square test. No statistically significant differences were observed for PD and CAL between T1 and T2 in both groups. For GI and PI significant difference was observed between the groups. For the evaluated microbial parameters was observed reduction of P.g. and P.i., but only for P.g. with a significant reduction in both groups. The full mouth scaling technique with the methodology used in this study provided improved clinical conditions and reduction of P.g. in subjects with moderate periodontitis, optimizing the time spent in the therapeutic execution.
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