| 1. |
- Buckwar, Evelyn, et al.
(author)
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A splitting method for SDEs with locally Lipschitz drift : Illustration on the FitzHugh-Nagumo model
- 2022
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In: Applied Numerical Mathematics. - : Elsevier BV. - 0168-9274. ; 179, s. 191-220
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Journal article (peer-reviewed)abstract
- In this article, we construct and analyse an explicit numerical splitting method for a class of semi-linear stochastic differential equations (SDEs) with additive noise, where the drift is allowed to grow polynomially and satisfies a global one-sided Lipschitz condition. The method is proved to be mean-square convergent of order 1 and to preserve important structural properties of the SDE. First, it is hypoelliptic in every iteration step. Second, it is geometrically ergodic and has an asymptotically bounded second moment. Third, it preserves oscillatory dynamics, such as amplitudes, frequencies and phases of oscillations, even for large time steps. Our results are illustrated on the stochastic FitzHugh-Nagumo model and compared with known mean-square convergent tamed/truncated variants of the Euler-Maruyama method. The capability of the proposed splitting method to preserve the aforementioned properties may make it applicable within different statistical inference procedures. In contrast, known Euler-Maruyama type methods commonly fail in preserving such properties, yielding ill-conditioned likelihood-based estimation tools or computationally infeasible simulation-based inference algorithms.
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| 2. |
- Buckwar, Evelyn, et al.
(author)
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A stochastic hierarchical model for low grade glioma evolution
- 2023
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In: Journal of Mathematical Biology. - 0303-6812. ; 86:6
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Journal article (peer-reviewed)abstract
- A stochastic hierarchical model for the evolution of low grade gliomas is proposed. Starting with the description of cell motion using a piecewise diffusion Markov process (PDifMP) at the cellular level, we derive an equation for the density of the transition probability of this Markov process based on the generalised Fokker–Planck equation. Then, a macroscopic model is derived via parabolic limit and Hilbert expansions in the moment equations. After setting up the model, we perform several numerical tests to study the role of the local characteristics and the extended generator of the PDifMP in the process of tumour progression. The main aim focuses on understanding how the variations of the jump rate function of this process at the microscopic scale and the diffusion coefficient at the macroscopic scale are related to the diffusive behaviour of the glioma cells and to the onset of malignancy, i.e., the transition from low-grade to high-grade gliomas.
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| 3. |
- Tubikanec, Irene, et al.
(author)
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Qualitative properties of different numerical methods for the inhomogeneous geometric Brownian motion
- 2022
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In: Journal of Computational and Applied Mathematics. - : Elsevier BV. - 0377-0427. ; 406
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Journal article (peer-reviewed)abstract
- We provide a comparative analysis of qualitative features of different numerical methods for the inhomogeneous geometric Brownian motion (IGBM). The limit distribution of the IGBM exists, its conditional and asymptotic mean and variance are known and the process can be characterised according to Feller's boundary classification. We compare the frequently used Euler–Maruyama and Milstein methods, two Lie–Trotter and two Strang splitting schemes and two methods based on the ordinary differential equation (ODE) approach, namely the classical Wong–Zakai approximation and the recently proposed log-ODE scheme. First, we prove that, in contrast to the Euler–Maruyama and Milstein schemes, the splitting and ODE schemes preserve the boundary properties of the process, independently of the choice of the time discretisation step. Second, we prove that the limit distribution of the splitting and ODE methods exists for all stepsize values and parameters. Third, we derive closed-form expressions for the conditional and asymptotic means and variances of all considered schemes and analyse the resulting biases. While the Euler–Maruyama and Milstein schemes are the only methods which may have an asymptotically unbiased mean, the splitting and ODE schemes perform better in terms of variance preservation. The Strang schemes outperform the Lie–Trotter splittings, and the log-ODE scheme the classical ODE method. The mean and variance biases of the log-ODE scheme are very small for many relevant parameter settings. However, in some situations the two derived Strang splittings may be a better alternative, one of them requiring considerably less computational effort than the log-ODE method. The proposed analysis may be carried out in a similar fashion on other numerical methods and stochastic differential equations with comparable features.
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