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Träfflista för sökning "WFRF:(Butler Andrew) "

Search: WFRF:(Butler Andrew)

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1.
  • 2019
  • Journal article (peer-reviewed)
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2.
  • Kanai, M, et al. (author)
  • 2023
  • swepub:Mat__t
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3.
  • Clark, Andrew G., et al. (author)
  • Evolution of genes and genomes on the Drosophila phylogeny
  • 2007
  • In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 450:7167, s. 203-218
  • Journal article (peer-reviewed)abstract
    • Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae, persimilis, willistoni, mojavensis, virilis and grimshawi), illustrate how rates and patterns of sequence divergence across taxa can illuminate evolutionary processes on a genomic scale. These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Despite remarkable similarities among these Drosophila species, we identified many putatively non-neutral changes in protein-coding genes, non-coding RNA genes, and cis-regulatory regions. These may prove to underlie differences in the ecology and behaviour of these diverse species.
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4.
  • Niemi, MEK, et al. (author)
  • 2021
  • swepub:Mat__t
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5.
  • Alexandrov, Ludmil B., et al. (author)
  • Signatures of mutational processes in human cancer
  • 2013
  • In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 500:7463, s. 415-421
  • Journal article (peer-reviewed)abstract
    • All cancers are caused by somatic mutations; however, understanding of the biological processes generating these mutations is limited. The catalogue of somatic mutations from a cancer genome bears the signatures of the mutational processes that have been operative. Here we analysed 4,938,362 mutations from 7,042 cancers and extracted more than 20 distinct mutational signatures. Some are present in many cancer types, notably a signature attributed to the APOBEC family of cytidine deaminases, whereas others are confined to a single cancer class. Certain signatures are associated with age of the patient at cancer diagnosis, known mutagenic exposures or defects in DNA maintenance, but many are of cryptic origin. In addition to these genome-wide mutational signatures, hypermutation localized to small genomic regions, 'kataegis', is found in many cancer types. The results reveal the diversity of mutational processes underlying the development of cancer, with potential implications for understanding of cancer aetiology, prevention and therapy.
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6.
  • Nik-Zainal, Serena, et al. (author)
  • Landscape of somatic mutations in 560 breast cancer whole-genome sequences
  • 2016
  • In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 534:7605, s. 47-54
  • Journal article (peer-reviewed)abstract
    • We analysed whole-genome sequences of 560 breast cancers to advance understanding of the driver mutations conferring clonal advantage and the mutational processes generating somatic mutations. We found that 93 protein-coding cancer genes carried probable driver mutations. Some non-coding regions exhibited high mutation frequencies, but most have distinctive structural features probably causing elevated mutation rates and do not contain driver mutations. Mutational signature analysis was extended to genome rearrangements and revealed twelve base substitution and six rearrangement signatures. Three rearrangement signatures, characterized by tandem duplications or deletions, appear associated with defective homologous-recombination-based DNA repair: one with deficient BRCA1 function, another with deficient BRCA1 or BRCA2 function, the cause of the third is unknown. This analysis of all classes of somatic mutation across exons, introns and intergenic regions highlights the repertoire of cancer genes and mutational processes operating, and progresses towards a comprehensive account of the somatic genetic basis of breast cancer.
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7.
  • Nik-Zainal, Serena, et al. (author)
  • Mutational Processes Molding the Genomes of 21 Breast Cancers
  • 2012
  • In: Cell. - : Elsevier BV. - 1097-4172 .- 0092-8674. ; 149:5, s. 979-993
  • Journal article (peer-reviewed)abstract
    • All cancers carry somatic mutations. The patterns of mutation in cancer genomes reflect the DNA damage and repair processes to which cancer cells and their precursors have been exposed. To explore these mechanisms further, we generated catalogs of somatic mutation from 21 breast cancers and applied mathematical methods to extract mutational signatures of the underlying processes. Multiple distinct single- and double-nucleotide substitution signatures were discernible. Cancers with BRCA1 or BRCA2 mutations exhibited a characteristic combination of substitution mutation signatures and a distinctive profile of deletions. Complex relationships between somatic mutation prevalence and transcription were detected. A remarkable phenomenon of localized hypermutation, termed "kataegis,'' was observed. Regions of kataegis differed between cancers but usually colocalized with somatic rearrangements. Base substitutions in these regions were almost exclusively of cytosine at TpC dinucleotides. The mechanisms underlying most of these mutational signatures are unknown. However, a role for the APOBEC family of cytidine deaminases is proposed.
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8.
  • Nik-Zainal, Serena, et al. (author)
  • The Life History of 21 Breast Cancers
  • 2012
  • In: Cell. - : Elsevier BV. - 1097-4172 .- 0092-8674. ; 149:5
  • Journal article (peer-reviewed)abstract
    • Cancer evolves dynamically as clonal expansions supersede one another driven by shifting selective pressures, mutational processes, and disrupted cancer genes. These processes mark the genome, such that a cancer's life history is encrypted in the somatic mutations present. We developed algorithms to decipher this narrative and applied them to 21 breast cancers. Mutational processes evolve across a cancer's lifespan, with many emerging late but contributing extensive genetic variation. Subclonal diversification is prominent, and most mutations are found in just a fraction of tumor cells. Every tumor has a dominant subclonal lineage, representing more than 50% of tumor cells. Minimal expansion of these subclones occurs until many hundreds to thousands of mutations have accumulated, implying the existence of long-lived, quiescent cell lineages capable of substantial proliferation upon acquisition of enabling genomic changes. Expansion of the dominant subclone to an appreciable mass may therefore represent the final rate-limiting step in a breast cancer's development, triggering diagnosis.
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9.
  • Butler, Andrew, et al. (author)
  • The XXL Survey XVIII. ATCA 2.1 GHz radio source catalogue and source counts for the XXL-South field
  • 2018
  • In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 620
  • Journal article (peer-reviewed)abstract
    • The 2.1 GHz radio source catalogue of the 25 deg(2) ultimate XMM extragalactic survey south (XXL-S) field, observed with the Australia Telescope Compact Array (ATCA), is presented. The final radio mosaic achieved a resolution of similar to 4.8" and a median rms noise of sigma approximate to 41 mu Jy/beam. To date, this is the largest area radio survey to reach this flux density level. A total of 6350 radio components above 5 sigma are included in the component catalogue, 26.4% of which are resolved. Of these components, 111 were merged together to create 48 multiple-component radio sources, resulting in a total of 6287 radio sources in the source catalogue, 25.9% of which were resolved. A survival analysis revealed that the median spectral index of the Sydney University Molonglo Sky Survey (SUMSS) 843 MHz sources in the field is alpha = 0.75, consistent with the values of -0.7 to -0.8 commonly used to characterise radio spectral energy distributions of active galactic nuclei. The 2.1 GHz and 1.4 GHz di ff erential radio source counts are presented and compared to other 1.4 GHz radio surveys. The XXL-S source counts show good agreement with the other surveys.
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10.
  • Lindblad-Toh, Kerstin, et al. (author)
  • Genome sequence, comparative analysis and haplotype structure of the domestic dog.
  • 2005
  • In: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 438:7069, s. 803-19
  • Journal article (peer-reviewed)abstract
    • Here we report a high-quality draft genome sequence of the domestic dog (Canis familiaris), together with a dense map of single nucleotide polymorphisms (SNPs) across breeds. The dog is of particular interest because it provides important evolutionary information and because existing breeds show great phenotypic diversity for morphological, physiological and behavioural traits. We use sequence comparison with the primate and rodent lineages to shed light on the structure and evolution of genomes and genes. Notably, the majority of the most highly conserved non-coding sequences in mammalian genomes are clustered near a small subset of genes with important roles in development. Analysis of SNPs reveals long-range haplotypes across the entire dog genome, and defines the nature of genetic diversity within and across breeds. The current SNP map now makes it possible for genome-wide association studies to identify genes responsible for diseases and traits, with important consequences for human and companion animal health.
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  • Result 1-10 of 76
Type of publication
journal article (56)
reports (7)
book chapter (4)
conference paper (3)
other publication (1)
doctoral thesis (1)
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research review (1)
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Type of content
peer-reviewed (61)
other academic/artistic (6)
pop. science, debate, etc. (6)
Author/Editor
Butler, Andrew (30)
Åkerskog, Ann (10)
Ode Sang, Åsa (7)
Brennan, Paul (7)
Nik-Zainal, Serena (7)
Martin, Sancha (7)
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Richardson, Andrea L ... (7)
Tumino, Rosario (6)
Johansson, Mattias (6)
Bojesen, Stig E. (6)
Lissowska, Jolanta (6)
Le Marchand, Loïc (6)
Duell, Eric J. (6)
Futreal, P. Andrew (6)
Scelo, Ghislaine (6)
Aldrich, Melinda C (6)
Jaarsma, Tiny (5)
Overvad, Kim (5)
Trichopoulou, Antoni ... (5)
Manjer, Jonas (5)
Melander, Olle (5)
Adamo, Marianna (5)
Chioncel, Ovidiu (5)
Metra, Marco (5)
Taylor, Fiona (5)
Grankvist, Kjell (5)
Rennert, Gad (5)
Muller, David C. (5)
Cox, Angela (5)
Thomas, Gilles (5)
Borg, Åke (5)
Bakke, Per (5)
Alexandrov, Ludmil B ... (5)
Davies, Helen R. (5)
Lakhani, Sunil R. (5)
Ramakrishna, Manasa (5)
Span, Paul N. (5)
Campbell, Peter J. (5)
Stratton, Michael R. (5)
Johansson, Mikael (5)
Amos, Christopher I. (5)
Han, Younghun (5)
Holcatova, Ivana (5)
Zaridze, David (5)
Mukeria, Anush (5)
Janout, Vladimir (5)
Brunnström, Hans (5)
Risch, Angela (5)
Butler, Javed (5)
Ångman, Elin (5)
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University
Swedish University of Agricultural Sciences (28)
Lund University (20)
Karolinska Institutet (12)
Uppsala University (11)
Umeå University (8)
University of Gävle (7)
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Linköping University (5)
Stockholm University (4)
Chalmers University of Technology (4)
University of Gothenburg (2)
Royal Institute of Technology (2)
Linnaeus University (2)
Halmstad University (1)
Malmö University (1)
University of Skövde (1)
Blekinge Institute of Technology (1)
VTI - The Swedish National Road and Transport Research Institute (1)
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Language
English (69)
Swedish (6)
Spanish (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (29)
Agricultural Sciences (21)
Natural sciences (18)
Social Sciences (13)
Engineering and Technology (5)
Humanities (3)

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