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  • Result 1-4 of 4
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1.
  • Cho, Nathan H., et al. (author)
  • OpenCell : Endogenous tagging for the cartography of human cellular organization
  • 2022
  • In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 375:6585, s. 1143-
  • Journal article (peer-reviewed)abstract
    • Elucidating the wiring diagram of the human cell is a central goal of the postgenomic era. We combined genome engineering, confocal live-cell imaging, mass spectrometry, and data science to systematically map the localization and interactions of human proteins. Our approach provides a data-driven description of the molecular and spatial networks that organize the proteome. Unsupervised clustering of these networks delineates functional communities that facilitate biological discovery. We found that remarkably precise functional information can be derived from protein localization patterns, which often contain enough information to identify molecular interactions, and that RNA binding proteins form a specific subgroup defined by unique interaction and localization properties. Paired with a fully interactive website (opencell.czbiohub.org), our work constitutes a resource for the quantitative cartography of human cellular organization.
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2.
  • Bentham, James, et al. (author)
  • A century of trends in adult human height
  • 2016
  • In: eLIFE. - 2050-084X. ; 5
  • Journal article (peer-reviewed)abstract
    • Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.522.7) and 16.5 cm (13.319.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries.
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4.
  • Chandler, Jennifer A., et al. (author)
  • International Legal Approaches to Neurosurgery for Psychiatric Disorders
  • 2021
  • In: Frontiers in Human Neuroscience. - : Frontiers Media S.A.. - 1662-5161. ; 14
  • Research review (peer-reviewed)abstract
    • Neurosurgery for psychiatric disorders (NPD), also sometimes referred to as psychosurgery, is rapidly evolving, with new techniques and indications being investigated actively. Many within the field have suggested that some form of guidelines or regulations are needed to help ensure that a promising field develops safely. Multiple countries have enacted specific laws regulating NPD. This article reviews NPD-specific laws drawn from North and South America, Asia and Europe, in order to identify the typical form and contents of these laws and to set the groundwork for the design of an optimal regulation for the field. Key challenges for this design that are revealed by the review are how to define the scope of the law (what should be regulated), what types of regulations are required (eligibility criteria, approval procedures, data collection, and oversight mechanisms), and how to approach international harmonization given the potential migration of researchers and patients.
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  • Result 1-4 of 4
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journal article (3)
research review (1)
Type of content
peer-reviewed (4)
Author/Editor
Peeters, Petra H (2)
Overvad, Kim (2)
Kaaks, Rudolf (2)
Boeing, Heiner (2)
Trichopoulou, Antoni ... (2)
Norat, Teresa (2)
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Riboli, Elio (2)
Diaz, Alejandro (2)
Joffres, Michel (2)
McKee, Martin (2)
Salomaa, Veikko (2)
Lundqvist, Annamari (2)
Giwercman, Aleksande ... (2)
Wade, Alisha N. (2)
Cooper, Cyrus (2)
Hardy, Rebecca (2)
Sunyer, Jordi (2)
Brenner, Hermann (2)
Claessens, Frank (2)
Craig, Cora L. (2)
Sjostrom, Michael (2)
Adams, Robert (2)
Thijs, Lutgarde (2)
Staessen, Jan A (2)
Schutte, Aletta E. (2)
Farzadfar, Farshad (2)
Geleijnse, Johanna M ... (2)
Guessous, Idris (2)
Jonas, Jost B. (2)
Kasaeian, Amir (2)
Khader, Yousef Saleh (2)
Khang, Young-Ho (2)
Lotufo, Paulo A. (2)
Malekzadeh, Reza (2)
Mensink, Gert B. M. (2)
Mohan, Viswanathan (2)
Nagel, Gabriele (2)
Qorbani, Mostafa (2)
Rivera, Juan A. (2)
Sepanlou, Sadaf G. (2)
Szponar, Lucjan (2)
Alkerwi, Ala'a (2)
Bjertness, Espen (2)
Kengne, Andre P. (2)
McGarvey, Stephen T. (2)
Shiri, Rahman (2)
Topor-Madry, Roman (2)
Branca, Francesco (2)
Damasceno, Albertino (2)
Rosengren, Annika (2)
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Uppsala University (3)
Umeå University (2)
University of Gothenburg (1)
Royal Institute of Technology (1)
Luleå University of Technology (1)
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Language
English (4)
Research subject (UKÄ/SCB)
Medical and Health Sciences (3)
Natural sciences (1)
Social Sciences (1)

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