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- 2019
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Journal article (peer-reviewed)
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- Hori, Yasunori, et al.
(author)
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The Discovery and Follow-up of Four Transiting Short-period Sub-Neptunes Orbiting M Dwarfs
- 2024
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In: Astronomical Journal. - 1538-3881 .- 0004-6256. ; 167:6
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Journal article (peer-reviewed)abstract
- Sub-Neptunes with radii of 2-3 R ⊕ are intermediate in size between rocky planets and Neptune-sized planets. The orbital properties and bulk compositions of transiting sub-Neptunes provide clues to the formation and evolution of close-in small planets. In this paper, we present the discovery and follow-up of four sub-Neptunes orbiting M dwarfs (TOI-782, TOI-1448, TOI-2120, and TOI-2406), three of which were newly validated by ground-based follow-up observations and statistical analyses. TOI-782 b, TOI-1448 b, TOI-2120 b, and TOI-2406 b have radii of R p = 2.740 − 0.079 + 0.082 R ⊕ , 2.769 − 0.068 + 0.073 R ⊕ , 2.120 ± 0.067 R ⊕, and 2.830 − 0.066 + 0.068 R ⊕ and orbital periods of P = 8.02, 8.11, 5.80, and 3.08 days, respectively. Doppler monitoring with the Subaru/InfraRed Doppler instrument led to 2σ upper limits on the masses of <19.1 M ⊕, <19.5 M ⊕, <6.8 M ⊕, and <15.6 M ⊕ for TOI-782 b, TOI-1448 b, TOI-2120 b, and TOI-2406 b, respectively. The mass-radius relationship of these four sub-Neptunes testifies to the existence of volatile material in their interiors. These four sub-Neptunes, which are located above the so-called “radius valley,” are likely to retain a significant atmosphere and/or an icy mantle on the core, such as a water world. We find that at least three of the four sub-Neptunes (TOI-782 b, TOI-2120 b, and TOI-2406 b), orbiting M dwarfs older than 1 Gyr, are likely to have eccentricities of e ∼ 0.2-0.3. The fact that tidal circularization of their orbits is not achieved over 1 Gyr suggests inefficient tidal dissipation in their interiors.
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- Axfors, Cathrine, et al.
(author)
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Association between convalescent plasma treatment and mortality in COVID-19 : a collaborative systematic review and meta-analysis of randomized clinical trials
- 2021
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In: BMC Infectious Diseases. - : BioMed Central (BMC). - 1471-2334. ; 21:1
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Research review (peer-reviewed)abstract
- Background: Convalescent plasma has been widely used to treat COVID-19 and is under investigation in numerous randomized clinical trials, but results are publicly available only for a small number of trials. The objective of this study was to assess the benefits of convalescent plasma treatment compared to placebo or no treatment and all-cause mortality in patients with COVID-19, using data from all available randomized clinical trials, including unpublished and ongoing trials (Open Science Framework, ). Methods: In this collaborative systematic review and meta-analysis, clinical trial registries (ClinicalTrials.gov, WHO International Clinical Trials Registry Platform), the Cochrane COVID-19 register, the LOVE database, and PubMed were searched until April 8, 2021. Investigators of trials registered by March 1, 2021, without published results were contacted via email. Eligible were ongoing, discontinued and completed randomized clinical trials that compared convalescent plasma with placebo or no treatment in COVID-19 patients, regardless of setting or treatment schedule. Aggregated mortality data were extracted from publications or provided by investigators of unpublished trials and combined using the Hartung-Knapp-Sidik-Jonkman random effects model. We investigated the contribution of unpublished trials to the overall evidence. Results: A total of 16,477 patients were included in 33 trials (20 unpublished with 3190 patients, 13 published with 13,287 patients). 32 trials enrolled only hospitalized patients (including 3 with only intensive care unit patients). Risk of bias was low for 29/33 trials. Of 8495 patients who received convalescent plasma, 1997 died (23%), and of 7982 control patients, 1952 died (24%). The combined risk ratio for all-cause mortality was 0.97 (95% confidence interval: 0.92; 1.02) with between-study heterogeneity not beyond chance (I-2 = 0%). The RECOVERY trial had 69.8% and the unpublished evidence 25.3% of the weight in the meta-analysis. Conclusions: Convalescent plasma treatment of patients with COVID-19 did not reduce all-cause mortality. These results provide strong evidence that convalescent plasma treatment for patients with COVID-19 should not be used outside of randomized trials. Evidence synthesis from collaborations among trial investigators can inform both evidence generation and evidence application in patient care.
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- Ari Noriega, Jorge, et al.
(author)
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Does ecotourism impact biodiversity? : An assessment using dung beetles (Coleoptera: Scarabaeinae) as bioindicators in a tropical dry forest natural park
- 2020
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In: Ecological Indicators. - : Elsevier. - 1470-160X .- 1872-7034. ; 117
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Journal article (peer-reviewed)abstract
- Ecotourism can be defined as an environmental activity that takes place in well-preserved areas for recreation and with the responsibility of promoting their conservation. Nowadays, ecotourism is seen as a friendly pastime, but it can potentially affect negatively community diversity and structure by a number of processes such as soil compaction, erosion, and habitat alteration, among many others. Nonetheless, there is hardly any information on the impact of ecotourism in the Tropical Dry Forests and protected areas of the Neotropical region. In an attempt to fill this knowledge gap, the effect of ecotourism was evaluated in a study of a Tropical Dry Forest in the Tayrona National Natural Park of Colombia using dung beetles as bioindicators. A large-scale sampling of three sites with different levels of tourism intensity (no tourism - NT, low tourism - LT, and high tourism - HT) was performed using pitfall tramps baited with human/pig dung during two climatic seasons (rainy and dry). A total of 3238 individuals belonging to nine genera and 15 species were collected. Significant differences in abun-dances, richness, and the Shannon Wiener diversity index were observed between areas with tourism and those without. These differences disappeared during the dry season in response to the strong reduction in species abundance and richness associated to that time of year. All areas maintained a homogeneous beetle structure in terms of functional groups present irrelevant of the intensity level of tourism. Beta diversity analysis shows that the dung beetle assemblage has a nested structure, indicating that the pressure exerted by tourism entails the loss of particular species. Our results advocate that it is necessary to implement conservation strategies in order to reduce the negative impact of tourism on the National Park's biodiversity.
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