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1.	Engelbrecht, Eric, et al. (author) Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta 2020 In: eLIFE. - : ELIFE SCIENCES PUBLICATIONS LTD. - 2050-084X. ; 9 Journal article (peer-reviewed)abstract Despite the medical importance of G protein-coupled receptors (GPCRs), in vivo cellular heterogeneity of GPCR signaling and downstream transcriptional responses are not understood. We report the comprehensive characterization of transcriptomes (bulk and single-cell) and chromatin domains regulated by sphingosine 1-phosphate receptor-1 (S1PR1) in adult mouse aortic endothelial cells. First, S1PR1 regulates NF kappa B and nuclear glucocorticoid receptor pathways to suppress inflammation-related mRNAs. Second, S1PR1 signaling in the heterogenous endothelial cell (EC) subtypes occurs at spatially-distinct areas of the aorta. For example, a transcriptomically distinct arterial EC population at vascular branch points (aEC1) exhibits ligand-independent S1PR1/beta-arrestin coupling. In contrast, circulatory S1P-dependent S1PR1/beta-arrestin coupling was observed in non-branch point aEC2 cells that exhibit an inflammatory gene expression signature. Moreover, S1P/S1PR1 signaling regulates the expression of lymphangiogenic and inflammation-related transcripts in an adventitial lymphatic EC (LEC) population in a ligand-dependent manner. These insights add resolution to existing concepts of endothelial heterogeneity, GPCR signaling and S1P biology.
2.	Benjamin, Daniel J., et al. (author) Redefine statistical significance 2018 In: Nature Human Behaviour. - : Nature Research (part of Springer Nature). - 2397-3374. ; 2:1, s. 6-10 Journal article (other academic/artistic)

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Type of publication: journal article (2)

Type of content: other academic/artistic (1); peer-reviewed (1)

Author/Editor: Dreber Almenberg, An ... (1); Johannesson, Magnus (1); Kirchler, Michael (1); Munafò, Marcus R. (1); Nosek, Brian A. (1); Vanlandewijck, Micha ... (1); show more...; Camerer, Colin (1); Betsholtz, Christer (1); McCarthy, Michael (1); Xie, Yu (1); He, Liqun (1); Cesarini, David (1); Ioannidis, John P. A ... (1); Laibson, David (1); Benjamin, Daniel J. (1); Berger, James O. (1); Fehr, Ernst (1); Fidler, Fiona (1); Field, Andy P. (1); Forster, Malcolm (1); George, Edward I. (1); Greenwald, Anthony (1); Green, Edwin (1); Gonzalez, Richard (1); Goodman, Steven (1); Green, Donald P. (1); Nakagawa, Shinichi (1); Nyhan, Brendan (1); Parker, Timothy H. (1); Pericchi, Luis (1); Perugini, Marco (1); Rouder, Jeff (1); Rousseau, Judith (1); Savalei, Victoria (1); Schoenbrodt, Felix D ... (1); Sellke, Thomas (1); Sinclair, Betsy (1); Tingley, Dustin (1); Van Zandt, Trisha (1); Vazire, Simine (1); Watts, Duncan J. (1); Winship, Christopher (1); Wolpert, Robert L. (1); Young, Cristobal (1); Hadfield, Jarrod D. (1); Hedges, Larry V. (1); Held, Leonhard (1); Ho, Teck-Hua (1); Hoijtink, Herbert (1); Hruschka, Daniel J. (1); show less...

University: Uppsala University (1); Stockholm School of Economics (1); Karolinska Institutet (1)

Language: English (2)

Research subject (UKÄ/SCB): Natural sciences (1); Medical and Health Sciences (1)

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