| 1. |
- Berthomier, M., et al.
(author)
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Alfven : magnetosphere-ionosphere connection explorers
- 2012
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In: Experimental astronomy. - Dordrecht : Springer. - 0922-6435 .- 1572-9508. ; 33:2-3, s. 445-489
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Journal article (peer-reviewed)abstract
- The aurorae are dynamic, luminous displays that grace the night skies of Earth's high latitude regions. The solar wind emanating from the Sun is their ultimate energy source, but the chain of plasma physical processes leading to auroral displays is complex. The special conditions at the interface between the solar wind-driven magnetosphere and the ionospheric environment at the top of Earth's atmosphere play a central role. In this Auroral Acceleration Region (AAR) persistent electric fields directed along the magnetic field accelerate magnetospheric electrons to the high energies needed to excite luminosity when they hit the atmosphere. The "ideal magnetohydrodynamics" description of space plasmas which is useful in much of the magnetosphere cannot be used to understand the AAR. The AAR has been studied by a small number of single spacecraft missions which revealed an environment rich in wave-particle interactions, plasma turbulence, and nonlinear acceleration processes, acting on a variety of spatio-temporal scales. The pioneering 4-spacecraft Cluster magnetospheric research mission is now fortuitously visiting the AAR, but its particle instruments are too slow to allow resolve many of the key plasma physics phenomena. The Alfv,n concept is designed specifically to take the next step in studying the aurora, by making the crucial high-time resolution, multi-scale measurements in the AAR, needed to address the key science questions of auroral plasma physics. The new knowledge that the mission will produce will find application in studies of the Sun, the processes that accelerate the solar wind and that produce aurora on other planets.
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| 2. |
- Alqeeq, S. W., et al.
(author)
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Investigation of the homogeneity of energy conversion processes at dipolarization fronts from MMS measurements
- 2022
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In: Physics of Plasmas. - : American Institute of Physics (AIP). - 1070-664X .- 1089-7674. ; 29:1
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Journal article (peer-reviewed)abstract
- We report on six dipolarization fronts (DFs) embedded in fast earthward flows detected by the Magnetospheric Multiscale mission during a substorm event on 23 July 2017. We analyzed Ohm's law for each event and found that ions are mostly decoupled from the magnetic field by Hall fields. However, the electron pressure gradient term is also contributing to the ion decoupling and likely responsible for an electron decoupling at DF. We also analyzed the energy conversion process and found that the energy in the spacecraft frame is transferred from the electromagnetic field to the plasma (J & BULL; E > 0) ahead or at the DF, whereas it is the opposite (J & BULL; E < 0) behind the front. This reversal is mainly due to a local reversal of the cross-tail current indicating a substructure of the DF. In the fluid frame, we found that the energy is mostly transferred from the plasma to the electromagnetic field (J & BULL; E & PRIME; < 0) and should contribute to the deceleration of the fast flow. However, we show that the energy conversion process is not homogeneous at the electron scales due to electric field fluctuations likely related to lower-hybrid drift waves. Our results suggest that the role of DF in the global energy cycle of the magnetosphere still deserves more investigation. In particular, statistical studies on DF are required to be carried out with caution due to these electron scale substructures.
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| 3. |
- Alqeeq, S. W., et al.
(author)
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Two Classes of Equatorial Magnetotail Dipolarization Fronts Observed by Magnetospheric Multiscale Mission : A Statistical Overview
- 2023
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In: Journal of Geophysical Research - Space Physics. - : American Geophysical Union (AGU). - 2169-9380 .- 2169-9402. ; 128:10
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Journal article (peer-reviewed)abstract
- We carried out a statistical study of equatorial dipolarization fronts (DFs) detected by the Magnetospheric Multiscale mission during the full 2017 Earth's magnetotail season. We found that two DF classes are distinguished: class I (74.4%) corresponds to the standard DF properties and energy dissipation and a new class II (25.6%). This new class includes the six DF discussed in Alqeeq et al. (2022, ) and corresponds to a bump of the magnetic field associated with a minimum in the ion and electron pressures and a reversal of the energy conversion process. The possible origin of this second class is discussed. Both DF classes show that the energy conversion process in the spacecraft frame is driven by the diamagnetic current dominated by the ion pressure gradient. In the fluid frame, it is driven by the electron pressure gradient. In addition, we have shown that the energy conversion processes are not homogeneous at the electron scale mostly due to the variations of the electric fields for both DF classes.
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| 4. |
- Cherenko, M., et al.
(author)
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Venous thromboembolism in Cushing syndrome: results from an EuRRECa and Endo-ERN survey
- 2024
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In: Endocrine Connections. - 2049-3614. ; 13:6
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Journal article (peer-reviewed)abstract
- Background: Patients with Cushing syndrome (CS) are at increased risk of venous thromboembolism (VTE). Objective: The aim was to evaluate the current management of new cases of CS with a focus on VTE and thromboprophylaxis. Design and methods: A survey was conducted within those that report in the electronic reporting tool (e-REC) of the European Registries for Rare Endocrine Conditions (EuRRECa) and the involved main thematic groups (MTG’s) of the European Reference Networks for Rare Endocrine Disorders (Endo-ERN) on new patients with CS from January 2021 to July 2022. Results: Of 222 patients (mean age 44 years, 165 females), 141 patients had Cushing disease (64%), 69 adrenal CS (31%), and 12 patients with ectopic CS (5.4%). The mean follow-up period post-CS diagnosis was 15 months (range 3–30). Cortisol-lowering medications were initiated in 38% of patients. One hundred fifty-four patients (69%) received thromboprophylaxis (including patients on chronic anticoagulant treatment), of which low-molecular-weight heparins were used in 96% of cases. VTE was reported in six patients (2.7%), of which one was fatal: two long before CS diagnosis, two between diagnosis and surgery, and two postoperatively. Three patients were using thromboprophylaxis at time of the VTE diagnosis. The incidence rate of VTE in patients after Cushing syndrome diagnosis in our study cohort was 14.6 (95% CI 5.5; 38.6) per 1000 person-years. Conclusion: Thirty percent of patients with CS did not receive preoperative thromboprophylaxis during their active disease stage, and half of the VTE cases even occurred during this stage despite thromboprophylaxis. Prospective trials to establish the optimal thromboprophylaxis strategy in CS patients are highly needed. Significance statement The incidence rate of venous thromboembolism in our study cohort was 14.6 (95% CI 5.5; 38.6) per 1000 person-years. Notably, this survey showed that there is great heterogeneity regarding time of initiation and duration of thromboprophylaxis in expert centers throughout Europe.
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| 5. |
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| 6. |
- Chasapis, A., et al.
(author)
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Thin Current Sheets and Associated Electron Heating in Turbulent Space Plasma
- 2015
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In: Astrophysical Journal Letters. - : Institute of Physics Publishing (IOPP). - 2041-8205 .- 2041-8213. ; 804:1
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Journal article (peer-reviewed)abstract
- Intermittent structures, such as thin current sheets, are abundant in turbulent plasmas. Numerical simulations indicate that such current sheets are important sites of energy dissipation and particle heating occurring at kinetic scales. However, direct evidence of dissipation and associated heating within current sheets is scarce. Here, we show a new statistical study of local electron heating within proton-scale current sheets by using high-resolution spacecraft data. Current sheets are detected using the Partial Variance of Increments (PVI) method which identifies regions of strong intermittency. We find that strong electron heating occurs in high PVI (>3) current sheets while no significant heating occurs in low PVI cases (<3), indicating that the former are dominant for energy dissipation. Current sheets corresponding to very high PVI (>5) show the strongest heating and most of the time are consistent with ongoing magnetic reconnection. This suggests that reconnection is important for electron heating and dissipation at kinetic scales in turbulent plasmas.
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| 7. |
- Crona, Joakim, et al.
(author)
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ENSAT registry-based randomized clinical trials for adrenocortical carcinoma
- 2021
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In: European Journal of Endocrinology. - : Bioscientifica. - 0804-4643 .- 1479-683X. ; 184:2, s. R51-R59
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Research review (peer-reviewed)abstract
- Adrenocortical carcinoma (ACC) is an orphan disease lacking effective systemic treatment options. The low incidence of the disease and high cost of clinical trials are major obstacles in the search for improved treatment strategies. As a novel approach, registry-based clinical trials have been introduced in clinical research, so allowing for significant cost reduction, but without compromising scientific benefit. Herein, we describe how the European Network for the Study of Adrenal Tumours (ENSAT) could transform its current registry into one fit for a clinical trial infrastructure. The rationale to perform randomized registry-based trials in ACC is outlined including an analysis of relevant limitations and challenges. We summarize a survey on this concept among ENSAT members who expressed a strong interest in the concept and rated its scientific potential as high. Legal aspects, including ethical approval of registry-based randomization were identified as potential obstacles. Finally, we describe three potential randomized registry-based clinical trials in an adjuvant setting and for advanced disease with a high potential to be executed within the framework of an advanced ENSAT registry. Thus we, therefore, provide the basis for future registry-based trials for ACC patients. This could ultimately provide proof-of-principle of how to perform more effective randomized trials for an orphan disease.
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| 8. |
- Décréau, P.M.E. , Fergeau, P., Krasnosels'kikh, V., Le Guirriec, E., Lévêque , M., Martin, Ph. , Randriamboarison, O., Rauch, J. L., Sené, F. X., Séran, H. C., Trotignon, J.G. , Canu, P., Cornilleau, N., de Féraudy, H., Alleyne, H. , Yearby, K., Mögensen
(author)
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Early results from the Whisper instrument on Cluster: an overview.
- 2001
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In: Annales Geophysicae. ; 19:10, s. . 1241-1258
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Journal article (peer-reviewed)abstract
- The Whisper instrument yields two data sets: (i) the electron density determined via the relaxation sounder, and (ii) the spectrum of natural plasma emissions in the frequency band 2-80 kHz. Both data sets allow for the three-dimensional exploration of th
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| 9. |
- Farrell, W. M., et al.
(author)
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Mass unloading along the inner edge of the Enceladus plasma torus
- 2008
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In: Geophysical Research Letters. - 0094-8276 .- 1944-8007. ; 35:2, s. L02203-
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Journal article (peer-reviewed)abstract
- A major discovery made by the Cassini spacecraft at Saturn was the substantial mass ejection from the south pole of Enceladus. Previous studies show that this ejected gas can become ionized and subsequently load mass onto the connecting magnetic field lines near the moon. Radial diffusion then allows the mass-loaded field lines to move outward to similar to 15 R-s and inward to similar to 2 R-s, forming a plasma torus. We demonstrate herein that the mass is also '' unloaded '' along the inner edge of this plasma torus the edge incident with the plasma-absorbing A-ring. Interpreting down-drifting z-mode tones from active sites along the inner edge of the ion torus as emission near the local electron plasma frequency, f(pe), we can remotely-monitor this reduction in plasma density along the torus inner edge as a function time. We find that the down-drift of the z-mode tones corresponds typically to a plasma density change dn/dt similar to - 5x10(-4)/cm(3)-s and when integrated over an annulus defined by the outer edge of the A-ring, corresponds to a mass loss of similar to 40 kg/s. Using the z-mode tones, we also find locations where plasma mass from the ring-ionosphere is possibly loaded at 1 - 2 kg/s onto field lines near the Cassini gap.
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| 10. |
- Hasegawa, H., et al.
(author)
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Kelvin-Helmholtz waves at the Earth's magnetopause : Multiscale development and associated reconnection
- 2009
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In: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 114:12, s. A12207-
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Journal article (peer-reviewed)abstract
- We examine traversals on 20 November 2001 of the equatorial magnetopause boundary layer simultaneously at similar to 1500 magnetic local time (MLT) by the Geotail spacecraft and at similar to 1900 MLT by the Cluster spacecraft, which detected rolled-up MHD-scale vortices generated by the Kelvin-Helmholtz instability (KHI) under prolonged northward interplanetary magnetic field conditions. Our purpose is to address the excitation process of the KHI, MHD-scale and ion-scale structures of the vortices, and the formation mechanism of the low-latitude boundary layer (LLBL). The observed KH wavelength (>4 x 10(4) km) is considerably longer than predicted by the linear theory from the thickness (similar to 1000 km) of the dayside velocity shear layer. Our analyses suggest that the KHI excitation is facilitated by combined effects of the formation of the LLBL presumably through high-latitude magnetopause reconnection and compressional magnetosheath fluctuations on the dayside, and that breakup and/or coalescence of the vortices are beginning around 1900 MLT. Current layers of thickness a few times ion inertia length similar to 100 km and of magnetic shear similar to 60 degrees existed at the trailing edges of the vortices. Identified in one such current sheet were signatures of local reconnection: Alfvenic outflow jet within a bifurcated current sheet, nonzero magnetic field component normal to the sheet, and field-aligned beam of accelerated electrons. Because of its incipient nature, however, this reconnection process is unlikely to lead to the observed dusk-flank LLBL. It is thus inferred that the flank LLBL resulted from other mechanisms, namely, diffusion and/or remote reconnection unidentified by Cluster.
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