| 1. |
- Ericsson, Olle, et al.
(author)
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Clinical validation of a novel automated cell-free DNA screening assay for trisomies 21, 13, and 18 in maternal plasma.
- 2019
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In: Prenatal diagnosis. - : Wiley. - 1097-0223 .- 0197-3851. ; 39:11, s. 1011-1015
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Journal article (peer-reviewed)abstract
- To evaluate clinical performance of a new automated cell-free (cf)DNA assay in maternal plasma screening for trisomies 21, 18, and 13, and to determine fetal sex.Maternal plasma samples from 1200 singleton pregnancies were analyzed with a new non-sequencing cfDNA method, which is based on imaging and counting specific chromosome targets. Reference outcomes were determined by either cytogenetic testing, of amniotic fluid or chorionic villi, or clinical examination of neonates.The samples examined included 158 fetal aneuploidies. Sensitivity was 100% (112/112) for trisomy 21, 89% (32/36) for trisomy 18, and 100% (10/10) for trisomy 13. The respective specificities were 100%, 99.5%, and 99.9%. There were five first pass failures (0.4%), all in unaffected pregnancies. Sex classification was performed on 979 of the samples and 99.6% (975/979) provided a concordant result.The new automated cfDNA assay has high sensitivity and specificity for trisomies 21, 18, and 13 and accurate classification of fetal sex, while maintaining a low failure rate. The study demonstrated that cfDNA testing can be simplified and automated to reduce cost and thereby enabling wider population-based screening.
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| 2. |
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| 3. |
- Carlsson, Fredrik, et al.
(author)
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A Conceptual Framework for Time Distortion Analysis in Method Components
- 2014
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In: Enterprise, Business-Process and Information Systems Modeling. - Berlin, Heidelberg : Springer. - 9783662437445 - 9783662437452 ; , s. 454-463
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Conference paper (peer-reviewed)abstract
- The “software crisis” is still a prevailing problem to many organizations despite existence of advanced systems engineering methods, techniques for project planning and method engineering; systems engineering project still struggle to deliver on time and budget, and with sufficient quality. Existing research stresses that time leakage has a lever effect on economic outcome, which is not addressed in the abovementioned approaches. As part of an on-going research project we therefore extend existing method engineering concept to include time distortion analysis. This allows for analysis of resource use (productivity) in execution of method components. It has the potential to act as a) a tool for improving the execution of systems engineering processes, or b) criteria for selecting method parts to improve the systems engineering processes.
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| 4. |
- Carlsson, Fredrik, et al.
(author)
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IgE enhances specific antibody and T cell responses in mice overexpressing CD23
- 2007
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In: Scandinavian Journal of Immunology. - : Wiley. - 0300-9475 .- 1365-3083. ; 66:2-3, s. 261-270
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Journal article (peer-reviewed)abstract
- IgE administered with its specific antigen in vivo induces enhanced proliferation of specific T cells as well as enhanced production of specific antibodies. Both effects are dependent on the low-affinity receptor for IgE (CD23) and the underlying mechanism is thought to be increased antigen presentation following uptake of IgE/antigen complexes via CD23+ B cells. By contrast, CD23 negatively regulates antibody responses to antigens administered with alum, i.e. without IgE. This effect has been observed as low IgG1 and IgE responses in transgenic mice overexpressing CD23 (CD23Tg). The present study was designed to test whether IgE could enhance antibody and T-cell responses in CD23Tg animals or whether CD23's downregulatory effect precludes IgE-mediated enhancement. IgE-anti-TNP administered with OVA-TNP enhances the OVA-specific antibody responses in wild-type (wt) and CD23Tg mice equally well. Interestingly, the total magnitude of antibody responses to IgE + OVA-TNP and to uncomplexed OVA-TNP, as well as to sheep erythrocytes and keyhole limpet haemocyanine, were lower in the CD23Tg mice. IgE induced proliferation of OVA-specific CD4+ T cells to the same degree in wt and CD23Tg mice. The effect on T cells was dependent on CD23+ B cells as demonstrated in in vitro proliferation assays. In conclusion, CD23 does indeed have dual immunoregulatory effects in the same animal. The receptor mediates enhancement of antibody and T-cell responses to IgE-complexed antigen, most likely via increased presentation of complexed antigen, while it negatively regulates the total antibody response to a variety of antigens.
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| 5. |
- Carlsson, Ingegerd, et al.
(author)
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Mature and immature defenses. A study of repressors and trait anxiety groups
- 2008
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In: Process and Personality. Actualization of the personal world with process-oriented methods. - 9783938793893 ; , s. 127-142
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Book chapter (other academic/artistic)abstract
- To investigate defense mechanisms, repressors (n= 14), highly anxious (n = 37) and low anxious (n = 7) groups were tested with the Meta Contrast Technique (Smith, Johnson, Almgren & Johanson, 2001). The division into repressors and anxiety groups was made on a larger group (N = 140), which was also investigated with respect to experienced access to preconscious processes, here operationalized as memory for dreams. Results: The repressors got higher scores on immature defense mechanisms than the highly or low anxious groups (p = .04 versus p < .05). The repressors as well as the highly anxious group were higher on a measure of overall defense than the low anxious group (p < .05 in both comparisons). Regarding the separate defense categories, a significant difference was found for repression, which was more frequent in the highly anxious than in the low anxious group (p = .003). Memory for dreams differed only in the men. The male repressors scored significantly lower on dream memory than the highly anxious men (p < .02). The immature defensive structure in the repressors was discussed in terms of regressive reactions, speculatively due to a lack of symbolic functioning concerning anxiety-arousing areas, i.e. alexithymia.
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| 6. |
- Carlsson, Magnus, et al.
(author)
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The effect of ball temperature on ball speed and carry distance in golf drives
- 2018
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In: Proceedings of the Institution of Mechanical Engineers, Part P. - London, UK : Sage Publications. - 1754-3371. ; 233:2, s. 186-192
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Journal article (peer-reviewed)abstract
- The purpose of this study was to investigate the effect of ball temperature on impact ball speed and carry distance during golf drives in a blind randomized test design. The balls were exposed to a temperature-controlled environment (4 °C, 18 °C, 32 °C, and 46 °C) for 24 h prior to the test and each temperature group consisted of 30 balls. The 120 drives were performed by an elite male golfer (handicap: 0.0) in an indoor driving range. All drives were measured by a Doppler-radar system to determine the club-head speed, launch angle, spin rate, ball speed, and carry distance. Differences between the groups were investigated using a one-way analysis of variance. The results indicated that ball-speed and carry-distance differences occurred within the four groups (p < 0.001 and p < 0.01, respectively). The post hoc analyses showed that the ball temperatures of 18 °C and 32 °C had greater ball speeds and carry distances than balls at 4 °C and 46 °C (all p < 0.05). The intervals for the between-group differences were 0.6–0.7 m s –1 and 2.9–3.9 m for ball speed and carry distance, respectively. Hence, the results showed that ball temperature influences both the ball speed and the carry distance. Based on the findings in this study, standardization of ball temperature should be factored into governing body regulation tests for golf equipment. © IMechE 2018.
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| 8. |
- Carlsson, Rickard, et al.
(author)
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Backlash and hiring : A field experiment on agency, communion, and gender
- 2015
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Conference paper (peer-reviewed)abstract
- Gender stereotypes describe women as communal and men asagentic. Laboratory based research (Rudman & Glick 1999; 2001)suggests that trying to disconfirm such descriptive genderstereotypes (e.g., women self-promoting their agency), entails therisk of hiring discrimination due to violation of prescriptive genderstereotypes: a backlash. To examine whether backlash occurs whenapplying for real jobs, we conducted a field experiment. Gender,agency and communion were manipulated in the personal profile of5,562 applications sent to 3,342 job openings on the Swedish labormarket. The dependent variable was whether the applicationresulted in an invitation to a job interview or not. The results do notoffer any support for the backlash hypothesis at this stage in therecruitment process.
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| 9. |
- Carlsson, Rickard, et al.
(author)
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Testing for backlash in hiring : A field experiment on agency, communion,and gender
- 2013
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Reports (other academic/artistic)abstract
- It has been suggested that women (men) who appear agentic (communal) when applying for jobs suffer a backlash in the form of reduced chances of being hired. However, the evidence of backlash is mainly restricted to simulated hiring decisions with undergraduates as participants. To examine whether backlash occurs when men and women apply for real jobs in the labor market, we conducted a field experiment. Gender, agentic and communal traits were manipulated in the applications. Whether or not the applications resulted in a job interview invitation constituted the dependent variable. We find no evidence of backlash, suggesting that women are not punished for presenting themselves as agentic in their job applications, nor are men punished for appearing communal.
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| 10. |
- Carlsson, Rickard, et al.
(author)
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Testing for backlash in hiring: A field experiment on agency, communion and gender.
- 2014
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In: Journal of Personnel Psychology. - : Hogrefe Publishing Group. - 2190-5150 .- 1866-5888. ; 13:4, s. 204-214
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Journal article (peer-reviewed)abstract
- Gender stereotypes describe women as communal and men as agentic. Laboratory-based research (Rudman & Glick, 1999, 2001) suggests that trying to disconfirm such descriptive gender stereotypes (e.g., women self-promoting their agency), entails the risk of hiring discrimination due to violation of prescriptive gender stereotypes: a backlash. To examine whether backlash occurs when applying for real jobs, we conducted a field experiment. Gender, agency, and communion were manipulated in the personal profile of 5,562 applications sent to 3,342 job openings on the Swedish labor market. The dependent variable was whether the application resulted in an invitation to a job interview or not. The results do not offer any support for the backlash hypothesis at this stage in the recruitment process.
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