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  • Persson, Björn, et al. (author)
  • Molecular evidence of stereo-specific lactoferrin dimers in solution.
  • 2010
  • In: Biophysical Chemistry. - : Elsevier BV. - 1873-4200 .- 0301-4622. ; 151:3, s. 187-189
  • Journal article (peer-reviewed)abstract
    • Gathering experimental evidence suggests that bovine as well as human lactoferrin self-associate in aqueous solution. Still, a molecular level explanation is unavailable. Using force field based molecular modeling of the protein-protein interaction free energy we demonstrate (1) that lactoferrin forms highly stereo-specific dimers at neutral pH and (2) that the self-association is driven by a high charge complementarity across the contact surface of the proteins. Our theoretical predictions of dimer formation are verified by electrophoretic mobility and N-terminal sequence analysis on bovine lactoferrin.
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Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Lund, Mikael (1)
Forsman, Jan (1)
Åkesson, Torbjörn (1)
Persson, Björn (1)
Chatterton, Dereck E ... (1)
University
Lund University (1)
Language
English (1)
Research subject (UKÄ/SCB)
Natural sciences (1)
Year
2010 (1)

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