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  • Chinthakindi, Praveen Kumar, et al. (author)
  • Sulfonimidamides in Medicinal and Agricultural Chemistry
  • 2017
  • In: Angewandte Chemie International Edition. - : Wiley. - 1433-7851. ; 56:15, s. 4100-4109
  • Journal article (peer-reviewed)abstract
    • The synthesis and evaluation of structural analogues and isosteres are of central importance in medicinal and agricultural chemistry. The sulfonamide functional group represents one of the most important amide isosteres in contemporary drug design, and about 500 such compounds have overcome both the pharmacological and regulatory hurdles that precede studies in humans. The mono aza analogues of sulfonamides, that is, sulfonimidamides, are rapidly gaining popularity as a novel functional group among synthetic chemists involved in the design of biologically active compounds for both pharmaceutical and agrochemical applications. Herein, we review these recent developments to showcase the promise of this functional group.
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