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Träfflista för sökning "WFRF:(Claesson P) "

Search: WFRF:(Claesson P)

  • Result 1-10 of 165
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  • Nicolas-Boluda, A., et al. (author)
  • Intracellular Fate of Hydrophobic Nanocrystal Self-Assemblies in Tumor Cells
  • 2020
  • In: Advanced Functional Materials. - : Wiley-VCH Verlag. - 1616-301X .- 1616-3028. ; 30:40
  • Journal article (peer-reviewed)abstract
    • Control of interactions between nanomaterials and cells remains a biomedical challenge. A strategy is proposed to modulate the intralysosomal distribution of nanoparticles through the design of 3D suprastructures built by hydrophilic nanocrystals (NCs) coated with alkyl chains. The intracellular fate of two water-dispersible architectures of self-assembled hydrophobic magnetic NCs: hollow deformable shells (colloidosomes) or solid fcc particles (supraballs) is compared. These two self-assemblies display increased cellular uptake by tumor cells compared to dispersions of the water-soluble NC building blocks. Moreover, the self-assembly structures increase the NCs density in lysosomes and close to the lysosome membrane. Importantly, the structural organization of NCs in colloidosomes and supraballs are maintained in lysosomes up to 8 days after internalization, whereas initially dispersed hydrophilic NCs are randomly aggregated. Supraballs and colloidosomes are differently sensed by cells due to their different architectures and mechanical properties. Flexible and soft colloidosomes deform and spread along the biological membranes. In contrast, the more rigid supraballs remain spherical. By subjecting the internalized suprastructures to a magnetic field, they both align and form long chains. Overall, it is highlighted that the mechanical and topological properties of the self-assemblies direct their intracellular fate allowing the control intralysosomal density, ordering, and localization of NCs.
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  • Woitowich, N. C., et al. (author)
  • Structural basis for light control of cell development revealed by crystal structures of a myxobacterial phytochrome
  • 2018
  • In: Iucrj. - : International Union of Crystallography (IUCr). - 2052-2525. ; 5:Part 5, s. 619-634
  • Journal article (peer-reviewed)abstract
    • Phytochromes are red-light photoreceptors that were first characterized in plants, with homologs in photosynthetic and non-photosynthetic bacteria known as bacteriophytochromes (BphPs). Upon absorption of light, BphPs interconvert between two states denoted Pr and Pfr with distinct absorption spectra in the red and far-red. They have recently been engineered as enzymatic photoswitches for fluorescent-marker applications in non-invasive tissue imaging of mammals. This article presents cryo- and room-temperature crystal structures of the unusual phytochrome from the non-photosynthetic myxobacterium Stigmatella aurantiaca (SaBphP1) and reveals its role in the fruitingbody formation of this photomorphogenic bacterium. SaBphP1 lacks a conserved histidine (His) in the chromophore-binding domain that stabilizes the Pr state in the classical BphPs. Instead it contains a threonine (Thr), a feature that is restricted to several myxobacterial phytochromes and is not evolutionarily understood. SaBphP1 structures of the chromophore binding domain (CBD) and the complete photosensory core module (PCM) in wild-type and Thr-to-His mutant forms reveal details of the molecular mechanism of the Pr/Pfr transition associated with the physiological response of this myxobacterium to red light. Specifically, key structural differences in the CBD and PCM between the wild-type and the Thr-to-His mutant involve essential chromophore contacts with proximal amino acids, and point to how the photosignal is transduced through the rest of the protein, impacting the essential enzymatic activity in the photomorphogenic response of this myxobacterium.
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  • Result 1-10 of 165
Type of publication
journal article (144)
conference paper (13)
other publication (3)
reports (2)
book chapter (2)
research review (1)
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Type of content
peer-reviewed (144)
other academic/artistic (21)
Author/Editor
Claesson, A. (32)
Claesson, P. (29)
Nordberg, P (28)
Ringh, M (27)
Hollenberg, J (24)
Svensson, L (19)
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Jonsson, M (17)
Forsberg, S (15)
Claesson-Welsh, Lena (13)
Claesson, Per M. (13)
Larsson, P (11)
Claesson, HE (11)
Djarv, T. (7)
Bjorkholm, M (7)
Thorslund, M (6)
Claesson, PM (6)
Fastbom, J (6)
Winblad, B (5)
Djärv, T. (5)
Rosenqvist, M (5)
Claesson, Per Martin (5)
Klint, P. (5)
Berglund, E. (4)
Swerin, Agne (4)
Jakobsson, PJ (4)
Westenhoff, Sebastia ... (4)
Claesson, S (4)
Liu, C. (3)
Sjoberg, J (3)
Schmidt, A. (3)
Johnson, S. (3)
Tolmachev, Vladimir (3)
Essand, Magnus (3)
Claesson, L (3)
Dobryden, Illia (3)
Schmidt, M. (3)
Backman, L (3)
Thormann, Esben (3)
Berg, S. (3)
Bergenståhl, B. (3)
Dods, Robert, 1989 (3)
Båth, Petra, 1988 (3)
Webber, J (3)
Kupitz, C. (3)
Claesson, B (3)
Claesson, Åsa (3)
Dedinaite, A. (3)
Abelairas-Gómez, C (3)
Bierens, J (3)
Perkins, GD (3)
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University
Karolinska Institutet (55)
RISE (50)
Uppsala University (33)
Royal Institute of Technology (30)
University of Gothenburg (11)
Linköping University (4)
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Luleå University of Technology (3)
Lund University (3)
University of Borås (3)
Umeå University (2)
Örebro University (1)
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Language
English (159)
Swedish (5)
Undefined language (1)
Research subject (UKÄ/SCB)
Natural sciences (27)
Medical and Health Sciences (21)
Engineering and Technology (8)
Agricultural Sciences (1)
Social Sciences (1)

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