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1.	Arnison, Paul G., et al. (author) Ribosomally synthesized and post-translationally modified peptide natural products : overview and recommendations for a universal nomenclature 2013 In: Natural product reports (Print). - : Royal Society of Chemistry (RSC). - 0265-0568 .- 1460-4752. ; 30:1, s. 108-160 Research review (peer-reviewed)abstract This review presents recommended nomenclature for the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs), a rapidly growing class of natural products. The current knowledge regarding the biosynthesis of the >20 distinct compound classes is also reviewed, and commonalities are discussed.
2.	Lam, Hubert, et al. (author) D-amino acids govern stationary phase cell wall remodeling in bacteria 2009 In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 325:5947, s. 1552-1555 Journal article (peer-reviewed)abstract In all known organisms, amino acids are predominantly thought to be synthesized and used as their L-enantiomers. Here, we found that bacteria produce diverse D-amino acids as well, which accumulate at millimolar concentrations in supernatants of stationary phase cultures. In Vibrio cholerae, a dedicated racemase produced D-Met and D-Leu, whereas Bacillus subtilis generated D-Tyr and D-Phe. These unusual D-amino acids appear to modulate synthesis of peptidoglycan, a strong and elastic polymer that serves as the stress-bearing component of the bacterial cell wall. D-Amino acids influenced peptidoglycan composition, amount, and strength, both by means of their incorporation into the polymer and by regulating enzymes that synthesize and modify it. Thus, synthesis of D-amino acids may be a common strategy for bacteria to adapt to changing environmental conditions.

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Type of publication: journal article (1); research review (1)

Type of content: peer-reviewed (2)

Author/Editor: Clardy, Jon (2); Göransson, Ulf (1); Craik, David J. (1); Cava, Felipe (1); Sivonen, Kaarina (1); de Pedro, Miguel A. (1); show more...; Liu, Wen (1); Severinov, Konstanti ... (1); Arnison, Paul G. (1); Bibb, Mervyn J. (1); Bierbaum, Gabriele (1); Bowers, Albert A. (1); Bugni, Tim S. (1); Bulaj, Grzegorz (1); Camarero, Julio A. (1); Campopiano, Dominic ... (1); Challis, Gregory L. (1); Cotter, Paul D. (1); Dawson, Michael (1); Dittmann, Elke (1); Donadio, Stefano (1); Dorrestein, Pieter C ... (1); Entian, Karl-Dieter (1); Fischbach, Michael A ... (1); Garavelli, John S. (1); Gruber, Christian W. (1); Haft, Daniel H. (1); Hemscheidt, Thomas K ... (1); Hertweck, Christian (1); Hill, Colin (1); Horswill, Alexander ... (1); Jaspars, Marcel (1); Kelly, Wendy L. (1); Klinman, Judith P. (1); Kuipers, Oscar P. (1); Link, A. James (1); Marahiel, Mohamed A. (1); Mitchell, Douglas A. (1); Moll, Gert N. (1); Moore, Bradley S. (1); Mueller, Rolf (1); Nair, Satish K. (1); Nes, Ingolf F. (1); Norris, Gillian E. (1); Olivera, Baldomero M ... (1); Onaka, Hiroyasu (1); Patchett, Mark L. (1); Piel, Joern (1); Reaney, Martin J. T. (1); Rebuffat, Sylvie (1); show less...

University: Umeå University (1); Uppsala University (1)

Language: English (2)

Research subject (UKÄ/SCB): Natural sciences (1)

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