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- Kanai, M, et al.
(author)
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- 2023
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swepub:Mat__t
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| 4. |
- Sánchez-Busó, Leonor, et al.
(author)
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A community-driven resource for genomic epidemiology and antimicrobial resistance prediction of Neisseria gonorrhoeae at Pathogenwatch
- 2021
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In: Genome Medicine. - : BioMed Central. - 1756-994X. ; 13:1
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Journal article (peer-reviewed)abstract
- BACKGROUND: Antimicrobial-resistant (AMR) Neisseria gonorrhoeae is an urgent threat to public health, as strains resistant to at least one of the two last-line antibiotics used in empiric therapy of gonorrhoea, ceftriaxone and azithromycin, have spread internationally. Whole genome sequencing (WGS) data can be used to identify new AMR clones and transmission networks and inform the development of point-of-care tests for antimicrobial susceptibility, novel antimicrobials and vaccines. Community-driven tools that provide an easy access to and analysis of genomic and epidemiological data is the way forward for public health surveillance.METHODS: Here we present a public health-focussed scheme for genomic epidemiology of N. gonorrhoeae at Pathogenwatch ( https://pathogen.watch/ngonorrhoeae ). An international advisory group of experts in epidemiology, public health, genetics and genomics of N. gonorrhoeae was convened to inform on the utility of current and future analytics in the platform. We implement backwards compatibility with MLST, NG-MAST and NG-STAR typing schemes as well as an exhaustive library of genetic AMR determinants linked to a genotypic prediction of resistance to eight antibiotics. A collection of over 12,000 N. gonorrhoeae genome sequences from public archives has been quality-checked, assembled and made public together with available metadata for contextualization.RESULTS: AMR prediction from genome data revealed specificity values over 99% for azithromycin, ciprofloxacin and ceftriaxone and sensitivity values around 99% for benzylpenicillin and tetracycline. A case study using the Pathogenwatch collection of N. gonorrhoeae public genomes showed the global expansion of an azithromycin-resistant lineage carrying a mosaic mtr over at least the last 10 years, emphasising the power of Pathogenwatch to explore and evaluate genomic epidemiology questions of public health concern.CONCLUSIONS: The N. gonorrhoeae scheme in Pathogenwatch provides customised bioinformatic pipelines guided by expert opinion that can be adapted to public health agencies and departments with little expertise in bioinformatics and lower-resourced settings with internet connection but limited computational infrastructure. The advisory group will assess and identify ongoing public health needs in the field of gonorrhoea, particularly regarding gonococcal AMR, in order to further enhance utility with modified or new analytic methods.
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| 5. |
- Schram, C., et al.
(author)
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Innovative noise control in ducts
- 2017
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In: 23rd AIAA/CEAS Aeroacoustics Conference, 2017. - Reston, Virginia : American Institute of Aeronautics and Astronautics. - 9781624105043
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Conference paper (peer-reviewed)abstract
- This paper explores approaches to reduce the noise produced and propagated in the Environmental Control System (ECS) of aircraft. The work has been done as part of a FP7 EU-project “Integrated Design of Optimal Ventilation Systems for Low Cabin and Ramp Noise” (IDEALVENT). A strong constraint that is taken into account concerns the overall efficiency and reliability of the control. Passive strategies, which do not inject additional energy into the system, are adopted for the sake of safety and energy consumption. The mitigation operates on two fronts: flow and acoustic control, using turbulence grids to dampen out the inflow inhomogeneity and turbulence, and micro-perforates for acoustic absorption. In this paper the focus is on describing the novel results obtained by the use of so called micro-perforated plates (MPP’s) for in-duct noise control.
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