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- Athanasiadou, Maria, et al.
(author)
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Polybrominated diphenyl ethers (PBDEs) and bioaccumulative hydroxylated PBDE metabolites in young humans from Managua, Nicaragua.
- 2008
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In: Environ Health Perspect. - : Environmental Health Perspectives. - 0091-6765 .- 1552-9924. ; 116:3, s. 400-8
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Journal article (peer-reviewed)abstract
- OBJECTIVE: Our aim was to investigate exposure to polybrominated diphenyl ethers (PBDEs) in a young urban population in a developing country, with focus on potentially highly exposed children working informally as scrap scavengers at a large municipal waste disposal site. We also set out to investigate whether hydroxylated metabolites, which not hitherto have been found retained in humans, could be detected. METHODS: We assessed PBDEs in pooled serum samples obtained in 2002 from children 11-15 years of age, working and sometimes also living at the municipal waste disposal site in Managua, and in nonworking urban children. The influence of fish consumption was evaluated in the children and in groups of women 15-44 years of age who differed markedly in their fish consumption. Hydroxylated PBDEs were assessed as their methoxylated derivates. The chemical analyses were performed by gas chromatography/mass spectrometry, using authentic reference substances. RESULTS: The children living and working at the waste disposal site showed very high levels of medium brominated diphenyl ethers. The levels observed in the referent children were comparable to contemporary observations in the United States. The exposure pattern was consistent with dust being the dominating source. The children with the highest PBDE levels also had the highest levels of hydroxylated metabolites. CONCLUSIONS: Unexpectedly, very high levels of PBDEs were found in children from an urban area in a developing country. Also, for the first time, hydroxylated PBDE metabolites were found to bioaccumulate in human serum.
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- Blanton, Michael R., et al.
(author)
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Sloan Digital Sky Survey IV : Mapping the Milky Way, Nearby Galaxies, and the Distant Universe
- 2017
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In: Astronomical Journal. - : IOP Publishing Ltd. - 0004-6256 .- 1538-3881. ; 154:1
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Journal article (peer-reviewed)abstract
- We describe the Sloan Digital Sky Survey IV (SDSS-IV), a project encompassing three major spectroscopic programs. The Apache Point Observatory Galactic Evolution Experiment 2 (APOGEE-2) is observing hundreds of thousands of Milky Way stars at high resolution and. high signal-to-noise ratios in the near-infrared. The Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey is obtaining spatially resolved spectroscopy for thousands of nearby galaxies (median z similar to 0.03). The extended Baryon Oscillation Spectroscopic Survey (eBOSS) is mapping the galaxy, quasar, and neutral gas distributions between z similar to 0.6 and 3.5 to constrain cosmology using baryon acoustic oscillations, redshift space distortions, and the shape of the power spectrum. Within eBOSS, we are conducting two major subprograms: the SPectroscopic IDentification of eROSITA Sources (SPIDERS), investigating X-ray AGNs. and galaxies in X-ray clusters, and the Time Domain Spectroscopic Survey (TDSS), obtaining spectra of variable sources. All programs use the 2.5 m Sloan Foundation Telescope at the. Apache Point Observatory; observations there began in Summer 2014. APOGEE-2 also operates a second near-infrared spectrograph at the 2.5 m du Pont Telescope at Las Campanas Observatory, with observations beginning in early 2017. Observations at both facilities are scheduled to continue through 2020. In keeping with previous SDSS policy, SDSS-IV provides regularly scheduled public data releases; the first one, Data Release 13, was made available in 2016 July.
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- Cuadra, Steven
(author)
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Child labour and health hazards: chemical exposure and occupational injuries in Nicaraguan children working in a waste disposal site
- 2005
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Licentiate thesis (other academic/artistic)abstract
- About 600 children and teenagers work at Managua's landfill, the largest in Nicaragua. They collect and sort waste at the open dump, which covers an area of 7 km2 on the outskirts of the city on the shores of Lake Managua. Such work, which occurs in many large cities in developing countries, is considered to be one of the riskiest types of child labor that exists. Nevertheless, knowledge of such work and its risks is lacking.We investigated chemical exposure and risk of injury among 103 child laborers aged 6 to 15 years from Managua's landfill. Almost half of the children also lived in the dump area itself, while the rest lived in a nearby area, Acahualinca. For comparison, 102 children from Acahualinca and 34 children from central Managua, 10 km away, who did not work at the dump, were also studied. This provided the opportunity to also study the environmental exposure from the landfill. The children were interviewed about living conditions, working conditions, and all injuries that occurred at workplaces, at school, and at home during the last 12 months. They had to provide blood samples for examination of the levels of, among other things, heavy metals such as lead, mercury, and cadmium, and persistent organic environmental toxins such as pesticides and PCBs. We also investigated the levels of a relatively new organic environmental poison, the brominated flame retardant PBDE. At a later stage, soil samples were also collected from the landfill area and from Acahualinca for investigation of metal content.The children who worked at the landfill had higher levels of lead, mercury, and cadmium than the children in the comparison groups. One-third had blood lead levels higher than 100 μg/l, a level where measures to reduce exposure are clearly recommended. We also found that the children in the nearby residential area had higher lead levels than the children from central Managua. Although mercury levels were higher among the child workers, the levels were not such that they could be considered a present and clear health risk. Consumption of fish from Lake Managua only slightly affected mercury levels. The levels of several of the organic environmental toxins, especially PCBs, were also higher among the child workers than in the comparison groups. We know that PCBs, which have long been banned in the West, are still used in Central America, or stored in uncontrolled forms. The children in the comparison groups also had clearly higher levels of a breakdown product of the pesticide DDT and of PCBs than children in the USA and Western Europe. The levels of these substances are steadily decreasing in the Western world. There is extremely limited knowledge of how the development over time looks like in Central and Latin America because too few surveys have been carried out. Unexpectedly, we found extremely high levels of PBDEs among the children living and working at the dump, higher than previously reported. The children in the comparison groups also had unexpectedly high levels of these substances. This is the first investigation of human PBDE levels in Central and Latin America, and the findings clearly show that it is extremely important to study the spread of the new environmental toxins also in non-industrialized countries and among particularly vulnerable groups. Several of the different substances that we studied are toxic to reproduction, and they can negatively affect human reproduction and fetal development. It would therefore have been desirable to be able to make a balanced risk assessment, but this is not possible because there is a lack of knowledge about the synergistic effects of the substances, and especially about how other factors such as inadequate nutrition can further affect the risk picture. What is clear, however, is that the levels we found among the children are significant from a reproductive perspective, as many of the girls we surveyed will be mothers in a few years - a fifth of Managua's teenagers are pregnant or have given birth already.Injuries, which caused at least one day of absence from school or work, were seven times more common among the children working at the dump than among the children in the comparison groups. The vast majority of injuries occurred during work, corresponding to 2.2 injuries per 1000 working days. The children reported that approximately one in ten injuries had resulted in permanent disability or pain. We analyzed the injuries that occurred to clarify whether there were any clear injury patterns. Cuts and puncture wounds to the hands and feet in connection with material handling were most common and caused 70% of the injuries. This shows that simple protective measures – many children lack shoes and no one has gloves – could reduce the risk of injury. However, the most serious damage was caused by the vehicles at the dump.In our studies, we have wanted to measure exposure levels and quantify risks in order to clarify the situation of child workers, in the hope that increased knowledge and awareness can eventually contribute to change. We have also gained valuable knowledge about the levels of several common environmental toxins among ordinary poor city children in a developing country. This is something that has so far been too inadequately investigated.
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- Cuadra, Steven, et al.
(author)
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Persistent organochlorine pollutants in children working at a waste-disposal site and in young females with high fish consumption in Managua, Nicaragua
- 2006
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In: Ambio. - 0044-7447 .- 1654-7209. ; 35:3, s. 109-116
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Journal article (peer-reviewed)abstract
- The aim of this study was to assess persistent organochlorine pollutant (POP) levels in serum collected from children (11-15 years old) working and sometimes also living at the municipal waste-disposal site in Managua, located at the shore of Lake Managua, and in nonworking children living both nearby and also far away from the waste-disposal site. The influence of fish consumption was further evaluated by assessing POPS levels in serum from young women (15-24 years old) with markedly different patterns of fish consumption from Lake Managua. 2,2-bis(4-chlorophenyl)-1,1,1-trichloro-ethane (4,4’-DDT) and 2,2-bis(4-chlorophenyl)-1,1-dichloro-ethene (4,4-DDE), T-hexachlorocyclohexane (gamma-HCH), polychlorinated biphenyls, pentachlorophenol, and polychlorobiphenylols were quantified in all samples. In general, the levels observed were higher than those reported in children from developed countries, such as Germany and United States. Toxaphene, aldrin, dieldrin, and beta-HCH could not be identified in any sample. The children working at the waste-disposal site had higher levels of POPS compared with the nonworking reference groups. In children not working, there were also gradients for several POPs, according to vicinity to the waste-disposal site. Moreover, in children, as well as in young women, there were gradients according to fish consumption. The most abundant component was 4,4-DDE, but at levels still lower than those reported in children from malarious areas with a history of recent or current application of 4,4-DDT for vector control.
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- Hansson, Erik, et al.
(author)
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Mapping snakebite epidemiology in Nicaragua : pitfalls and possible solutions
- 2010
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In: PLoS neglected tropical diseases. - : Public Library of Science (PLoS). - 1935-2735. ; 4:11, s. e896-
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Journal article (peer-reviewed)abstract
- Using publicly available data, we identified areas likely to be underreporting snakebites and highlighted these areas instead of leaving them "white" on the incidence map. The effects of the case detection bias on the distribution of resources against snakebites could decrease. Although not yet verified empirically, our study provides an example of how snake bite epidemiology may be investigated in similar settings worldwide at a low cost.
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