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Search: WFRF:(Döring Gerd)

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  • Döring, Gerd, et al. (author)
  • Clinical trials in cystic fibrosis
  • 2007
  • In: Journal of Cystic Fibrosis. - : Elsevier BV. - 1569-1993 .- 1873-5010. ; 6:2, s. 85-99
  • Journal article (peer-reviewed)abstract
    • In patients with cystic fibrosis (CF), clinical trials are of paramount importance. Here, the current status of drug development in CF isdiscussed and future directions highlighted. Methods for pre-clinical testing of drugs with potential activity in CF patients including relevantanimal models are described. Study design options for phase II and phase III studies involving CF patients are provided, including requiredpatient numbers, safety issues and surrogate end point parameters for drugs, tested for different disease manifestations. Finally, regulatoryissues for licensing new therapies for CF patients are discussed, including new directives of the European Union and the structure of aEuropean clinical trial network for clinical studies involving CF patients is proposed.
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  • Result 1-1 of 1
Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Johannesson, Marie (1)
Döring, Gerd (1)
Elborn, J. Stuart (1)
de Jonge, Hugo (1)
Griese, Matthias (1)
Smyth, Alan (1)
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Heijerman, Harry (1)
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University
Uppsala University (1)
Language
English (1)
Year
2007 (1)

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