| 1. |
- Araujo de Pina Cabral, DB, et al.
(author)
-
Prospective evaluation of glutamine and phospholipids levels in first degree relatives of patients with Type 1 Diabetes from a multiethnic population
- 2015
-
In: Diabetology and Metabolic Syndrome. - : BioMed Central (BMC). - 1758-5996 .- 1758-5996. ; 7:52
-
Journal article (peer-reviewed)abstract
- BACKGROUND: A dysregulation in the metabolism of lipids may be an early marker of autoimmunity in Type 1 Diabetes (T1D). It would be of general importance to identify metabolic patterns that would predict the risk for T1D later in life. The aim of this study was to perform a prospective evaluation of glutamine and phospholipids levels in Brazilian first degree relatives (FDR) of patients with T1D in a mean interval of 5 years.FINDINGS: Brazilian FDR (n = 30) of patients with T1D were evaluated and blood was sampled to measure the levels of glutamine and phospholipids in the fasting serum by quantitative colorimetric method. The tests were repeated after a mean interval of 5 years and compared to a control group (n = 20). The FDR presented lower levels of phospholipids than controls (p = 0.028), but not of glutamine (p = 0.075). Phospholipids levels decreased over time (p = 0.028) in FDR and were associated with Glutamic acid decarboxylase autoantibody (GADA) titers (p = 0.045), autoantibody positivity (p = 0.008) and PTPN22 polymorphisms (p = 0.014).CONCLUSIONS: In this Brazilian multiethnic population, there was a significant decrease in phospholipids levels in FDR in patients with T1D during a 5-year prospective follow-up, as well as a significant association between these metabolite, GADA and PTPN22 polymorphisms. For Glutamine no difference was found. These findings suggest that a dysregulation in the metabolism of lipids may precede the onset of the autoimmunity in T1D.
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
- Da Silva, A. F., et al.
(author)
-
Electronic and optical properties of TiO2
- 2005
-
Conference paper (peer-reviewed)abstract
- The electronic and optical properties of the rutile titanium dioxide compound have been investigated experimentally by absorption measurements and theoretically by a full-potential linearized augmented plane wave (FPLAPW) method within the local density approximation (LDA). The thin films for the absorption measurements were prepared by DC magnetron sputtering. The theoretical results for the absorption compared qualitatively well with the experimental findings. The dielectric functions and band-structure have also been calculated, and the LDA band-gap energy is corrected by an on-site Coulomb potential.
|
|
| 5. |
- Da Silva, A. F., et al.
(author)
-
Linear optical response of Si1-xGex compounds
- 2005
-
In: Quantum Sensing and Nanophotonic Devices II. - : SPIE - International Society for Optical Engineering. - 081945706X ; 5732:1, s. 556-564
-
Conference paper (peer-reviewed)abstract
- Si1-xGex is a good candidate as a substitute material for Si in a low-power and high-speed semiconductor device technologies. Optical devices, such as heterojunction bipolar transistors, are already in industrial production. The samples are grown on Si(001) with both n-and p-type impurities and with different Ge concentrations. The linear optical response of Si 1-x Gex is investigated theoretically using a full-potential linearized augmented plane wave method with respect to composition x. The calculated real and imaginary parts of the dielectric function ε e(ω) = ε1(ω) + iε 2(ω) were found to be in good agreement with recent spectroscopic ellipsometry measurements performed by Bahng et al., J. Phys.: Condens. Matter 13, 777 (2001). We also perform absorption measurements for different type of samples showing the variation of energy gaps as a function of Ge concentrations.
|
|
