| 1. |
- Kanai, M, et al.
(author)
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- 2023
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swepub:Mat__t
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| 2. |
- Campbell, PJ, et al.
(author)
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Pan-cancer analysis of whole genomes
- 2020
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In: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 578:7793, s. 82-
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Journal article (peer-reviewed)abstract
- Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale1–3. Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4–5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter4; identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation5,6; analyses timings and patterns of tumour evolution7; describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity8,9; and evaluates a range of more-specialized features of cancer genomes8,10–18.
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| 3. |
- Jain, Sagar M., et al.
(author)
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An effective approach of vapour assisted morphological tailoring for reducing metal defect sites in lead-free, (CH3NH3)(3)Bi2I9 bismuth-based perovskite solar cells for improved performance and long-term stability
- 2018
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In: Nano Energy. - : ELSEVIER SCIENCE BV. - 2211-2855 .- 2211-3282. ; 49, s. 614-624
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Journal article (peer-reviewed)abstract
- We present a controlled, stepwise formation of methylammonium bismuth iodide (CH3NH3)(3)Bi2I9 perovskite films prepared via the vapour assisted solution process (VASP) by exposing BiI3 films to CH3NH3I (MAI) vapours for different reaction times, (CH3NH3)(3)Bi2I9 semiconductor films with tunable optoelectronic properties are obtained. Solar cells prepared on mesoporous TiO2 substrates yielded hysteresis-free efficiencies upto 3.17% with good reproducibility. The good performance is attributed mainly to the homogeneous surface coverage, improved stoichiometry, reduced metallic content in the bulk, and desired optoelectronic properties of the absorbing material. In addition, solar cells prepared using pure BiI3 films without MAI exposure achieved a power conversion efficiency of 0.34%. The non-encapsulated (CH3NH3)(3)Bi2I9 devices were found to be stable for as long as 60 days with only 0.1% drop in efficiency. This controlled formation of (CH3NH3)(3)Bi2I9 perovskite films highlights the benefit of the VASP technique to optimize material stoichiometry, morphology, solar cell performance, and long-term durability.
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| 4. |
- Petek, Nik, 1989-
(author)
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Archaeological Perspectives on Risk and Community Resilience in the Baringo Lowlands, Kenya
- 2018
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Doctoral thesis (other academic/artistic)abstract
- This historical ecological research provides a detailed insight into the risk avoidance and resilience building strategies in the Lake Baringo basin in Kenya through the lens of archaeology. It explores how changes in subsistence, habitation, and landscape shaped each other and how that affected the available strategies of risk avoidance and resilience building. While the focus is on the history and archaeology of the Ilchamus, a Maa community currently occupying the area, the research additionally investigated the late Holocene of the Baringo lowlands to provide a basis for the discussion on risk and resilience. A combination of remote sensing, foot surveys, excavation, and spatial statistic methods establishes a culture history for the region, showing that the Lake Baringo basin has been part of the pastoralist cultural sphere for the past three millennia and that the Rift Valley bottom possibly acted as a frontier between different archaeological cultures. By the end of the 18th or the beginning of the 19th century the area was occupied by Ilchamus. They established densely aggregated settlements and a vast irrigation system in order to enmesh themselves into the local, regional, and global exchange system. Through the exchange system, they would ensure their ‘social survival’ and build social contracts as part of their resilience building strategies, which continued to be practiced even as the Ilchamus subsistence and habitation practices as well as the political situation changed. However, as archaeological assemblages and ethnoarchaeological and historical data show, throughout their 200-year history community conformity and consolidation were central forces in the formation of an Ilchamus identity and a strong community resilience.The environmental degradation of the Lake Baringo area has been the subject of studies for almost a century with the subsistence practices of the local communities seen as a key cause for it. This research moves beyond blame but instead explores the options available and choices taken by the Ilchamus community in specific environmental and political contexts. I hope that this thesis provides some insights into new avenues of exploration of how we can develop and strengthen the resilience of vulnerable communities, such as Ilchamus.
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