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- 2017
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In: Physical Review D. - 2470-0010 .- 2470-0029. ; 96:2
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Journal article (peer-reviewed)
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| 2. |
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| 3. |
- Demichev, Vadim, et al.
(author)
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A proteomic survival predictor for COVID-19 patients in intensive care
- 2022
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In: PLOS Digital Health. - : Public Library of Science (PLoS). - 2767-3170. ; 1:1 January
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Journal article (peer-reviewed)abstract
- Global healthcare systems are challenged by the COVID-19 pandemic. There is a need to optimize allocation of treatment and resources in intensive care, as clinically established risk assessments such as SOFA and APACHE II scores show only limited performance for predicting the survival of severely ill COVID-19 patients. Additional tools are also needed to monitor treatment, including experimental therapies in clinical trials. Comprehensively capturing human physiology, we speculated that proteomics in combination with new data-driven analysis strategies could produce a new generation of prognostic discriminators. We studied two independent cohorts of patients with severe COVID-19 who required intensive care and invasive mechanical ventilation. SOFA score, Charlson comorbidity index, and APACHE II score showed limited performance in predicting the COVID-19 outcome. Instead, the quantification of 321 plasma protein groups at 349 timepoints in 50 critically ill patients receiving invasive mechanical ventilation revealed 14 proteins that showed trajectories different between survivors and non-survivors. A predictor trained on proteomic measurements obtained at the first time point at maximum treatment level (i.e. WHO grade 7), which was weeks before the outcome, achieved accurate classification of survivors (AUROC 0.81). We tested the established predictor on an independent validation cohort (AUROC 1.0). The majority of proteins with high relevance in the prediction model belong to the coagulation system and complement cascade. Our study demonstrates that plasma proteomics can give rise to prognostic predictors substantially outperforming current prognostic markers in intensive care.
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| 5. |
- Denker, B., et al.
(author)
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Hot YAG:Yb3+:Er3+ crystal-a potential laser medium for high average power 1.5 μm lasers
- 2006
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In: Advanced solid-state photonics 2006. - : Optical Society of America. - 1557527989 - 9781557527981
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Conference paper (peer-reviewed)abstract
- The near-IR spectroscopic properties of YAG:Yb:Er crystals were investigated at high temperatures. It is shown that at 600°-800°C temperatures they become close to their corresponding properties in Er,Yb: phosphate laser glasses.
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| 6. |
- Denker, B., et al.
(author)
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New crystalline material for 1.5 μm lasers : Yb,Er - Activated GdCa 4O(BO3)3
- 2004
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In: Advanced Solid-State Photonics. - Washington, D.C. : Optics Info Base, Optical Society of America. - 1557527717 ; , s. 430-434
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Conference paper (peer-reviewed)abstract
- A new crystalline medium for 1.5 μm Yb-Er lasers is proposed: GdCa 4O(BO3)3 (GdCOB). Its melting point allows crystal growth using platinum instead of iridium crucibles. Spectroscopic and laser tests of the new material are described. A maximum CW output power of 80 mW was achieved in a monolithic microchip cavity under laser diode pumping.
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| 10. |
- Hellstrom, J. E., et al.
(author)
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Laser performance of Yb : GdCa4O(BO3)(3) compared to Yb : KGd(WO4)(2) under diode-bar pumping
- 2007
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In: Laser physics. - : Pleiades Publishing Ltd. - 1054-660X .- 1555-6611. ; 17:10, s. 1204-1208
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Journal article (peer-reviewed)abstract
- A study of Yb:GdCOB under diode-bar pumping has been performed and the results are compared, experimentally and theoretically, with Yb:KGW in the same cavity. An output power of 7.3 W and a slope efficiency of 57.4% were obtained. Self-frequency-doubling experiments are also discussed.
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